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    Automated cassete module for an apparatus for conducting immunoassays and use thereof
    4.
    发明公开
    Automated cassete module for an apparatus for conducting immunoassays and use thereof 有权
    自动化盒的装置，用于执行immunoanalytischen测试和它们的使用方法

    公开(公告)号：EP1369473A2

    公开(公告)日：2003-12-10

    申请号：EP02022910.0

    申请日：2002-10-10

    申请人： CHOLESTECH CORPORATION

    发明人： Nugent, Anthony ,  Cowley, Leanne ,  Bellet, Neal ,  Shindelman, Jeffrey ,  Leos, Michael ,  Worthy, Thomas ,  Haley, Kimberly

    IPC分类号： C12M1/34 ,  G01N33/53 ,  G01N33/543 ,  G01N35/00 ,  C12M1/40

    CPC分类号： B01L9/52 ,  B01L3/5023 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0633 ,  G01N33/5304 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/54386 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81

    摘要： An immunoassay cassette 10, apparatus, and method for detecting an analyte in a liquid body-fluid sample are disclosed. The cassette 10 has a body 12 and a support mounted on the body 12, for movement toward and away from a sample transfer position. A sample supplied to a sample well 18 in the cassette body 12 is taken up by a reagent reservoir 24 containing a first reagent composition effective to react with one or more sample components to form a modified sample. The support 12 provides a reagent strip 30 having a transfer zone 32 that is brought into contact with the reservoir 24, when the support 14 is moved to its transfer position, a detection zone 34 located downstream of the transfer zone 32, and a second reagent composition effective to react with the modified sample to form a detectable analyte-dependent product. By controlling the movement of the support 14 toward and away from its transfer position, the volume and rate of sample flow from the reservoir 24 to the strip 30 can be controlled to optimize and/or standardize sample-transfer conditions in the assay.

    摘要翻译： 的免疫测定盒10，装置和用于液体体液样本中的分析物的检测方法是游离缺失盘。 磁带盒10具有一个主体12和安装在主体12的支撑为移动朝向和远离样品转印位置。 在盒体12供应到样品井18的样品通过一个试剂储存器24含有第一试剂组合物有效地与一个或多个样品组分反应以形成改性的样品吸收。 支撑体12提供了具有一转印区32的试剂条30也被带入与所述贮存器24，接触。当支撑件14被移动到其传送位置，位于转印区32下游的检测区34和第二试剂 组合物能有效地与改性样品反应以形成可检测的分析物依赖的产物。 通过控制朝向和远离其转印位置时，体积和从储存器24的样品流动的速率，以条带30可以被控制，以优化和/或在测定中标准化样品转移条件下支撑件14的运动。 的免疫测定盒10，装置和用于分析物的检测液体体液样品中的方法是游离缺失盘。 磁带盒10具有一个主体12和安装在主体12的支撑为移动朝向和远离样品转印位置。 在盒体12供应到样品井18的样品通过一个试剂储存器24含有第一试剂组合物有效地与一个或多个样品组分反应以形成改性的样品吸收。 支撑体12提供了具有一转印区32的试剂条30也被带入与所述贮存器24，接触。当支撑件14被移动到其传送位置，位于转印区32下游的检测区34和第二试剂 组合物能有效地与改性样品反应以形成可检测的分析物依赖的产物。 通过控制朝向和远离其转印位置时，体积和从储存器24的样品流动的速率，以条带30可以被控制，以优化和/或在测定中标准化样品转移条件下支撑件14的运动。

    Device and method for measuring HDL-cholesterol emplying precipitation on a solid-phase
    7.
    发明公开
    Device and method for measuring HDL-cholesterol emplying precipitation on a solid-phase 失效
    Vorrichtung und Verfahren zur Festphase-Präzipitationsbestimmungvon HDL-Cholesterin

    公开(公告)号：EP1028319A2

    公开(公告)日：2000-08-16

    申请号：EP00109181.8

    申请日：1991-07-15

    申请人： CHOLESTECH CORPORATION

    发明人： Jones, Ronald M.

    IPC分类号： G01N33/92 ,  B01D39/00 ,  B01D39/20

    CPC分类号： G01N33/92 ,  B01D39/2017 ,  B01D2239/0421 ,  B01D2239/0492 ,  C12Q1/60 ,  C12Q2326/00 ,  C12Q2326/96 ,  G01N33/526 ,  G01N2800/044 ,  Y10T436/104165

    摘要： An assay device (14) for measuring the concentration of a soluble analyte, such as HDL-associated cholesterol, in a fluid sample containing interfering compounds, such as LDL- or VLDL-associated cholesterol, which can be selectively precipitated. The device includes a sieving matrix (26) capable of separating soluble and precipitated material migrating through the matrix, and a reservoir (34) which holds a precipitating agent which is effective, within a given concentration range, to selectively precipitate the interfering compounds. The reservoir is designed to delay the release of agent, on contact with the fluid sample, to maintain the concentration of precipitating agent in contact with the fluid sample within the given concentration range. The device additionally includes an assay pad (64, 66, 68, 70) in which the soluble analyte present in the fluid sample can be assayed. A method of separating high-density lipoproteins (HDL) from low- and very-low-density lipoproteins (LDL and VLDL) employs a coated glass fiber matrix which inhibits binding of HDL as a blood fluid sample containing HDL and precipitated LDL and VLDL passes through the matrix.

    摘要翻译： 用于测量含有可被选择性沉淀的干扰化合物如LDL或VLDL相关胆固醇的流体样品中的可溶性分析物（例如HDL相关胆固醇）的浓度的测定装置（14）。 该装置包括能够分离通过基质迁移的可溶性和沉淀物质的筛分基质（26），和在给定浓度范围内保持有效的沉淀剂的储存器（34）以选择性地沉淀干扰化合物。 储存器旨在延迟试剂在与流体样品接触时的释放，以保持沉淀剂的浓度与给定浓度范围内的流体样品接触。 该装置还包括其中可以测定存在于流体样品中的可溶性分析物的测定垫（64,66,68,70）。 从低密度脂蛋白（HDL）和低密度脂蛋白（LDL和VLDL）分离高密度脂蛋白（HDL）的方法采用涂覆的玻璃纤维基质，其抑制HDL作为含有HDL和沉淀LDL和VLDL通过的血液样品的结合 通过矩阵。