公开(公告)号：EP2281196B1

公开(公告)日：2014-07-16

申请号：EP09751311.3

申请日：2009-05-18

申请人： IDEXX Laboratories Inc ,  Divergence, Inc.

发明人： ELSEMORE, David, Allen ,  GENG, Jinming ,  FLYNN, Laurie, A. ,  CRAWFORD, Michael

IPC分类号： G01N33/68

CPC分类号： G01N33/56966 ,  G01N33/5308 ,  G01N33/6893 ,  G01N2333/43526 ,  G01N2333/4353 ,  G01N2469/10

摘要： Methods, devices, kits and antibodies for detecting the presence or absence of one or more helminthic co-proantigens in a sample are disclosed herein. The methods, devices, kits and antibodies of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made for example, for the pupose of selecting an optimal course of treatment of the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

公开(公告)号：EP2281196A2

公开(公告)日：2011-02-09

申请号：EP09751311.3

申请日：2009-05-18

申请人： IDEXX Laboratories Inc ,  Divergence, Inc.

发明人： ELSEMORE, David, Allen ,  GENG, Jinming ,  FLYNN, Laurie, A. ,  CRAWFORD, Michael

IPC分类号： G01N33/53 ,  G01N33/569

CPC分类号： G01N33/56966 ,  G01N33/5308 ,  G01N33/6893 ,  G01N2333/43526 ,  G01N2333/4353 ,  G01N2469/10

摘要： Methods, devices, kits and antibodies for detecting the presence or absence of one or more helminthic co-proantigens in a sample are disclosed herein. The methods, devices, kits and antibodies of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made for example, for the pupose of selecting an optimal course of treatment of the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

摘要翻译： 本文公开了用于检测样品中是否存在一种或多种蠕虫状coproantigen的方法，装置，试剂盒和组合物。 本发明的方法，装置，试剂盒和组合物可用于确认来自哺乳动物的粪便样品中蛔虫，鞭虫和/或钩虫的存在或不存在，并且还能够区分一种或多种蠕虫感染。 例如，为了选择治疗哺乳动物的最佳疗程和/或为了确定哺乳动物是否已经摆脱目的，可以确定哺乳动物中是否存在蛔虫，鞭虫和/或钩虫 感染后的感染已经开始。

公开(公告)号：EP2184989A1

公开(公告)日：2010-05-19

申请号：EP08797800.3

申请日：2008-08-13

申请人： Divergence, Inc.

发明人： WILLIAMS, Deryck, J. ,  DIMMIC, Matt, W. ,  HAAKENSON, William, P., Jr. ,  WIDEMAN, Al ,  SHORTT, Barry, J. ,  CHEESERIGHT, Tim ,  CRAWFORD, Michael, J.

IPC分类号： A01N43/64

CPC分类号： A01N43/22 ,  A01N43/56 ,  A01N43/76 ,  A01N43/78 ,  A01N43/82 ,  A01N47/12 ,  A01N57/28 ,  A01N57/30 ,  A01N57/32 ,  C07D405/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

摘要： Compositions and processes for controlling nematodes are described herein, e.g., nematodes that infest plants or animals. The compounds 1,2,4-thiadiazole derivatives.

公开(公告)号：EP2166855A2

公开(公告)日：2010-03-31

申请号：EP08770443.3

申请日：2008-06-09

申请人： Divergence, Inc.

发明人： CRAWFORD, Michael J.

IPC分类号： A01N43/50 ,  A01N43/56 ,  A61K31/415

CPC分类号： A01N25/34 ,  A01K13/003 ,  A01K27/007 ,  A01N25/006 ,  A01N25/02 ,  A01N25/08 ,  A01N25/10 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A61K9/0017 ,  A61K31/415 ,  A61K31/505 ,  A61K31/517 ,  A01N2300/00

摘要： Disclosed is a method of controlling ectoparasites that infest companion and livestock animals by applying to the animal an effective amount of 4-tert-butylphenethyl quinazolin-4-yl ether or 4-chloro-5-ethyl-2-methyl-N-[(4-tert-butylphenyl)methyl]pyrazole-3-carboxamide or 5-chloro-N-[2-[4-(2-ethoxyethyl)-2,3-dimethylphenoxy]ethyl]-6-ethyl-4-pyrimidinamine or 4-chloro-3-ethyl-1-methyl -N-[4-(p-tolyloxy)benzyl]pyrazole-5-carboxamide.

公开(公告)号：EP1578929A4

公开(公告)日：2006-12-13

申请号：EP03761273

申请日：2003-06-23

申请人： DIVERGENCE INC

发明人： WILLIAMS DERYCK J ,  MCLAIRD MERRY B ,  HRESKO MICHELLE COUTU ,  FREVERT ANITA M ,  WORTHINGTON RONALD E ,  KLOEK ANDREW P ,  DAVILA-APONTE JENNIFER A ,  BRADLEY JOHN D ,  XU SIQUN

IPC分类号： C12N9/10 ,  C12N9/00 ,  C07H21/04 ,  C07K16/00 ,  G01N33/53

CPC分类号： C12N9/1007

摘要： Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production

摘要翻译： 描述了编码磷酸乙醇胺正甲基转移酶多肽的线虫的核酸分子。 还提供了PEAMT样多肽序列，载体，宿主细胞以及用于产生PEAMT样核苷酸和多肽的重组方法也是如此。 还描述了用于鉴定抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。

公开(公告)号：EP2396321A4

公开(公告)日：2012-12-19

申请号：EP10741639

申请日：2010-02-10

申请人： DIVERGENCE INC

发明人： SLOMCZYNSKA URSZULA ,  DIMMIC MATT W ,  HAAKENSON JR WILLIAM P ,  WIDEMAN AL

IPC分类号： C07D413/04 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/433 ,  A61P33/10 ,  C07D413/06 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12

CPC分类号： A01N43/653 ,  A01N43/82 ,  C07D413/04 ,  C07D413/06

摘要： Compositions and processes for controlling nematodes are described herein, e.g., nematodes that infest plants or animals. The compounds include oxazoles, oxadiazoles and thiadiazoles.

公开(公告)号：EP2270208B1

公开(公告)日：2012-05-09

申请号：EP10187881.7

申请日：2007-02-13

申请人： Divergence, Inc.

发明人： Jones, Jennifer

IPC分类号： C12Q1/68 ,  C40B40/06 ,  C12N15/10

CPC分类号： C12N15/1068 ,  C07K14/415 ,  C12N9/16 ,  C12N15/1044

公开(公告)号：EP2182062A3

公开(公告)日：2010-10-06

申请号：EP09003957.9

申请日：2005-08-02

申请人： Divergence, Inc.

发明人： Gasper, Michelle L. ,  Baublite, Catherine ,  Kloek, Andrew, P. ,  Davila-Aponte, Jennifer, A. ,  Hresko, Michelle, Coutu ,  McLaird, Merry, B. ,  Zentella, Rodolfo ,  Williams, Deryck, J.

IPC分类号： C12N15/09 ,  C12N15/82 ,  A01H5/00

CPC分类号： C12N9/0071 ,  C11B1/00 ,  C12N9/0073 ,  C12N15/8223 ,  C12N15/8247 ,  C12N15/8285 ,  Y02A40/164

摘要： The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues. Transgenic plants expressing such a polypeptide can also be useful for non-pesticidal industrial uses.

公开(公告)号：EP1984524A4

公开(公告)日：2009-09-30

申请号：EP07750756

申请日：2007-02-13

申请人： DIVERGENCE INC

发明人： JONES JENNIFER

IPC分类号： C12Q1/68 ,  C12N15/10 ,  C40B40/06

CPC分类号： C12N15/1068 ,  C07K14/415 ,  C12N9/16 ,  C12N15/1044

公开(公告)号：EP2396321A2

公开(公告)日：2011-12-21

申请号：EP10741639.8

申请日：2010-02-10

申请人： Divergence, Inc.

发明人： SLOMCZYNSKA, Urszula ,  DIMMIC, Matt, W. ,  HAAKENSON, Jr., William, P. ,  WIDEMAN, Al

IPC分类号： C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12

CPC分类号： A01N43/653 ,  A01N43/82 ,  C07D413/04 ,  C07D413/06

摘要： Compositions and processes for controlling nematodes are described herein, e.g., nematodes that infest plants or animals. The compounds include oxazoles, oxadiazoles and thiadiazoles.