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公开(公告)号：EP1489422B1
公开(公告)日：2018-06-06
申请号：EP04008226.5
申请日：2004-04-05
CPC分类号： C07H21/04
摘要： The present invention provides multisignal labeling reagents and these are useful in a number of biochemical applications, including the manufacture of biomolecular probes and their use in detecting or amplifying analyte-specific moieties.
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公开(公告)号：EP2499495B1
公开(公告)日：2016-03-30
申请号：EP10760465.4
申请日：2010-09-14
发明人： PATTON, Wayne, Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
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公开(公告)号：EP2993477A1
公开(公告)日：2016-03-09
申请号：EP15187863.4
申请日：2010-09-14
发明人： PATTON, Wayne Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
摘要翻译： 提供用于检测和监测自噬和磷脂病的测定法，包括溶酶体贮积病的进展。 可以监测溶酶体储存疾病的药物和治疗溶酶体贮积病条件的有效性。 药物候选人和疑似毒素也可以筛选对细胞，组织和器官的毒性。 还提供了用于区分磷脂肪激活剂和自噬途径扰动剂的方法。
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4.发明公开
公开(公告)号：EP2507319A2
公开(公告)日：2012-10-10
申请号：EP10795100.6
申请日：2010-11-30
发明人： PATTON, Wayne, Forrest , DAI, Lijun , LUDLAM, Anthony , YARMOLUK, Sergiy, M. , PANDE, Praveen , KOVALSKA, Vladyslava , VOLKOVA, Kateryna , COLEMAN, Jack , LOSYTSKYY, Mykhaylo , BALANDA, Anatoliy , SHEN, Dee
CPC分类号： C09B23/145 , C07D401/12 , C09B23/0008 , C09B23/0025 , C09B23/0058 , C09B23/0066 , C09B23/04 , C09B23/06 , C09B23/102 , C09B23/141 , G01N33/582 , G01N33/6845 , G01N2458/30 , G01N2800/2821 , G01N2800/2835
摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.
摘要翻译： 提供了可用于许多应用的染料和组合物，例如检测和监测蛋白质聚集，蛋白质聚集的动力学研究，神经原纤维斑块分析，蛋白质制剂稳定性的评估，蛋白质热稳定性转移测定和分子伴侣活性的分析 。 这些染料和组合物也可用作核酸和蛋白质检测中的探针。
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5.发明公开Labeling reagents and labeled tabeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses 审中-公开Markierungsstoffe und Markierungsprozesse zur Bestimmung vonNukleinsäuren
公开(公告)号：EP1348713A2
公开(公告)日：2003-10-01
申请号：EP03004894.6
申请日：2003-03-06
IPC分类号： C07H21/00 , C12Q1/68 , C07D487/22 , C07D221/12 , C07D321/00
CPC分类号： C07H21/00 , C09B23/02 , C09B47/00 , C09B57/00 , Y10S436/80
摘要： This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.
摘要翻译： 本发明提供标记试剂，标记的靶标和制备标记试剂的方法。 标记试剂可以采用花青染料，呫吨染料，卟啉染料，香豆素染料或复合染料的形式。 这些标记试剂可用于标记探针或靶标，包括核酸和蛋白质。 这些试剂可以有效地应用于基于蛋白质和基于核酸探针的测定。 它们也适用于实时检测过程。
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公开(公告)号：EP1348713B1
公开(公告)日：2019-01-23
申请号：EP03004894.6
申请日：2003-03-06
IPC分类号： C07H21/00 , C12Q1/68 , C07D487/22 , C07D221/12 , C07D321/00
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7.发明授权
公开(公告)号：EP2982245B1
公开(公告)日：2018-08-08
申请号：EP15182887.8
申请日：2009-12-04
IPC分类号： A01N43/78 , A61K31/425 , C07D401/14 , C07D405/14 , C07D417/06 , C07D417/14 , C09B23/04 , C09B23/06 , C09B23/08 , C09B23/10 , C09B23/14 , C09B23/00
CPC分类号： C09B23/164 , C09B23/0066 , C09B23/0075 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146 , C12Q1/68 , G01N33/583
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as protein, nucleic acids and cellular organelles, Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.
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公开(公告)号：EP2366797B1
公开(公告)日：2017-09-06
申请号：EP10182825.9
申请日：2002-07-01
IPC分类号： C12Q1/68
CPC分类号： C40B40/06 , B01J19/0046 , B01J2219/00599 , B01J2219/0061 , B01J2219/00612 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C12N15/1006 , C12N15/1058 , C12Q1/68 , C12Q1/6809 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/10 , G01N33/68 , C12Q2565/501 , C12Q2563/179 , C12Q2545/114 , C12Q2525/155 , C12Q2565/514 , C12Q2565/537
摘要： This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
摘要翻译： 本发明提供了用于分析物检测，定量和扩增的新型组合物和方法。 核酸阵列和分析物文库被有效地结合到这样的组合物和方法中。 通用检测元件，信号实体等被用来检测并且如果需要或期望，量化分析物。 目标分析物的扩增也由本发明的组合物和方法提供。
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9.发明公开COMPOSITIONS AND PROCESSES FOR ANALYTE DETECTION, QUANTIFICATION AND AMPLIFICATION 审中-公开分析物检测，量化和扩增的组成和过程
公开(公告)号：EP3208346A1
公开(公告)日：2017-08-23
申请号：EP16200296.8
申请日：2002-07-01
CPC分类号： C40B40/06 , B01J19/0046 , B01J2219/00599 , B01J2219/0061 , B01J2219/00612 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C12N15/1006 , C12N15/1058 , C12Q1/68 , C12Q1/6809 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/10 , G01N33/68 , C12Q2565/501 , C12Q2563/179 , C12Q2545/114 , C12Q2525/155 , C12Q2565/514 , C12Q2565/537
摘要： This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
摘要翻译： 本发明提供了用于分析物检测，定量和扩增的新型组合物和方法。 核酸阵列和分析物文库被有效地结合到这样的组合物和方法中。 通用检测元件，信号实体等被用来检测并且如果需要或期望，量化分析物。 目标分析物的扩增也由本发明的组合物和方法提供。
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10.发明公开
公开(公告)号：EP2877855A4
公开(公告)日：2016-03-02
申请号：EP13822167
申请日：2013-07-12
发明人： COLEMAN JACK , SZCZEPANIK MACIEJ , JIN RICHARD
CPC分类号： G01N33/54306 , C12Q1/68 , G01N33/58
摘要： Provided is a composition comprising an analyte bound to a polymer where the analyte is less than about 2000 MW and the polymer further comprises more than one signal or first member of a second binding pair. Also provided is an assay for an analyte comprising combining a sample suspected of containing the analyte with the above-described composition and a binding agent that binds to the analyte; and detecting the signal or the first member of the second binding pair that is bound to the binding agent. Additionally provided is a multisignal labeling reagent comprising a first polymer covalently bound to (a) a reactive group or a first member of a first binding pair, and (b) more than one digoxigenin molecule.
摘要翻译： 提供了包含共价键合或通过第一结合对与聚合物结合的分析物的组合物。 在该组合物中，分析物小于约2000MW; 所述聚合物还包含多于一个信号或第二结合对的第一个成员; 并且分析物不是第一结合对或第二结合对的成员。 还提供了分析物的测定法。 该测定包括：将怀疑含有分析物的样品与上述组合物结合，以及结合分析物的结合剂; 以及检测绑定到绑定剂的第二绑定对的信号或第一成员。 在该测定中，与结合剂结合的信号或第二结合对的第一个成员的量与样品中的分析物成反比。 另外提供了包含共价结合到（a）第一结合对的反应性基团或第一个成员的第一聚合物的多信号标记试剂，和（b）多于一个的地高辛分子。
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