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公开(公告)号：EP3348633A1
公开(公告)日：2018-07-18
申请号：EP16834336.6
申请日：2016-08-12
发明人： BATTESTI, Darci Moraes Barros , KERKIS, Irina , MENDONÇA, Ronaldo Zucatelli , MARIA, Durvanei Augusto , MORAES, Angelina Cirelli
CPC分类号： A61K39/0003 , A61K35/56 , A61K35/646 , A61K39/00 , A61K39/0233 , C07K14/29 , C12N1/10 , C12N1/20 , C12N5/0601 , G01N33/53
摘要： The invention refers to a process for the production of a continuous cell line of simile embryo stem cells, such as Amblyomma sculptum (Acari: Ixodidae), known as line IBU/ASE-16 (access number with CNCM: I-5000) and its uses. More specifically, the invention refers to a process for the production of the line IBU/ASE-16 and their use for obtaining extracts for the production of vaccines and candidate recombinant proteins for biopharmaceuticals and acaricides, production of diagnostic kits for the detection of antigens and/or antibodies for animal and human use, obtaining clones for use in genotyping and use as a substrate for the isolation and culture of pathogens.
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2.发明公开POLYNUCLEOTIDE, POLYPEPTIDE WITH IMMUNOSUPPRESIVE ACTIVITY, EXPRESSION CASSETTE, EXPRESSION VECTOR, HOST CELL, PHARMACEUTICAL COMPOSITION, METHODS FOR PRODUCING A POLYPETIDE WITH IMMUNOSUPPRESIVE ACTIVITY AND FOR PREVENTING OR TREATING CONDITIONS THAT REQUIRE IMMUNOSUPPRESION AND USE OF A POLYPEPTIDE 审中-公开多核苷酸，其与多肽免疫抑制活性，表达盒，表达载体，宿主细胞，药物组合物，用于生产多肽免疫抑制作用以及需要免疫抑制疾病的预防和治疗，以及使用多肽
公开(公告)号：EP3060236A1
公开(公告)日：2016-08-31
申请号：EP14855383.7
申请日：2014-10-24
申请人： Fundação Butantan
发明人： TAMBOURGI, Denise, V. , QUEIROZ, Giselle, Pidde , SANT'ANNA, Osvaldo, Augusto, Brazil, Esteves , MAGNOLI, Fábio, Carlos , PACHECO, Ogari, de Castro
CPC分类号： C07K14/46 , A61K38/00 , A61K39/001 , A61K39/38 , C07K14/4713
摘要： This invention refers to polynucleotides and non-hemorrhagic and non-immunogenic polypeptides of selective immunosuppressive activity on production of antibodies to antigens of different natures. The polypeptides described herein are useful for preparing pharmaceutical compositions for prevention or treatment of conditions that require immunosuppression, preferably, inflammatory, autoimmune, allergic and infectious diseases and rejection to transplanted organs.
摘要翻译： 本发明涉及多核苷酸和非出血性和生产抗体的不同性质的抗原的选择性的免疫抑制活性的非免疫原性多肽。 在所描述的多肽是确实需要免疫抑制，优选，炎性，自身免疫性，变应性和感染性疾病和排斥移植的器官用于制备药物组合物用于预防或治疗的病症。
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公开(公告)号：EP3581589A1
公开(公告)日：2019-12-18
申请号：EP18750991.4
申请日：2018-02-09
发明人： CHUDZINSKI-TAVASSI, Ana Marisa , DA SILVA, Bárbara Athayde Vaz Galvão , PASQUALOTO, Kerly Fernanda Mesquita , IWAI, Leo Kei , PORTO, Rafael Marques
IPC分类号： C07K19/00 , A61K39/116 , G01N33/569
摘要： The present invention relates to novel hybrid peptides developed from the combination of membrane surface protein peptide fragments present in anaplasmosis microorganisms, and in particular, bacteria of the species Anaplasma marginale. The present invention further relates to hybrid peptide sets, compositions and kits comprising such novel hybrid peptides, their uses and methods of inducing immune response. Each hybrid peptide, according to the present invention, comprises two or more peptide fragments of amino acid sequences as defined in the present invention linked together by means of a spacer element. The combined peptide fragments are protein peptide fragments of MSP1, MSP1a, MSP1b, MSP2, MSP2-HRV, MSP3, OMP7, OMP8, VirB9 and VirB10.
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4.发明公开METHOD FOR PRODUCING AND OBTAINING VARIABLE DOMAINS OF ANTI-DIGOXIN MONOCLONAL ANTIBODY FAB FRAGMENT USING THE MOLECULAR BIOLOGY CLONING TECHNIQUE 审中-公开方法用于生产和提炼变Fab片段单克隆抗地高辛抗体结构域利用分子生物学KLONUNGSVERFAHRENS
公开(公告)号：EP2851427A4
公开(公告)日：2016-03-02
申请号：EP13804686
申请日：2013-05-15
申请人： FUNDAÇÃO BUTANTAN
发明人： KALIL FILHO JORGE ELIAS , MORO ANA MARIA , MIDORI MURATA VIVIANE , RUMI TSURATA LILIAN , COSTA BRAGA SCHMIDT MARIANA
CPC分类号： C12N15/1037 , C07K16/16 , C07K16/44 , C07K2317/55
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公开(公告)号：EP3426267B1
公开(公告)日：2023-01-11
申请号：EP17712549.9
申请日：2017-03-09
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6.发明公开POLYNUCLEOTIDE, POLYPEPTIDE WITH IMMUNOSUPPRESIVE ACTIVITY, EXPRESSION CASSETTE, EXPRESSION VECTOR, HOST CELL, PHARMACEUTICAL COMPOSITION, METHODS FOR PRODUCING A POLYPETIDE WITH IMMUNOSUPPRESIVE ACTIVITY AND FOR PREVENTING OR TREATING CONDITIONS THAT REQUIRE IMMUNOSUPPRESION AND USE OF A POLYPEPTIDE 审中-公开多核苷酸，其与多肽免疫抑制活性，表达盒，表达载体，宿主细胞，药物组合物，用于生产多肽免疫抑制作用以及需要免疫抑制疾病的预防和治疗，以及使用多肽
公开(公告)号：EP3060236A4
公开(公告)日：2017-06-07
申请号：EP14855383
申请日：2014-10-24
申请人： FUNDAÇÃO BUTANTAN
发明人： TAMBOURGI DENISE V , QUEIROZ GISELLE PIDDE , SANT'ANNA OSVALDO AUGUSTO BRAZIL ESTEVES , MAGNOLI FÁBIO CARLOS , PACHECO OGARI DE CASTRO
CPC分类号： C07K14/46 , A61K38/00 , A61K39/001 , A61K39/38 , C07K14/4713
摘要： This invention refers to polynucleotides and non-hemorrhagic and non-immunogenic polypeptides of selective immunosuppressive activity on production of antibodies to antigens of different natures. The polypeptides described herein are useful for preparing pharmaceutical compositions for prevention or treatment of conditions that require immunosuppression, preferably, inflammatory, autoimmune, allergic and infectious diseases and rejection to transplanted organs.
摘要翻译： 本发明涉及多核苷酸和非出血性和生产抗体的不同性质的抗原的选择性的免疫抑制活性的非免疫原性多肽。 在所描述的多肽是确实需要免疫抑制，优选，炎性，自身免疫性，变应性和感染性疾病和排斥移植的器官用于制备药物组合物用于预防或治疗的病症。
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公开(公告)号：EP1809323A1
公开(公告)日：2007-07-25
申请号：EP04761533.1
申请日：2004-09-13
申请人： FUNDAÇÃO BUTANTAN
发明人： RAW, Isaias , KUBRUSLY, Flávia Saldanha , DIAS, Waldely de Oliveira , ESTEVES, Maria Izabel , FURUYAMA, Noemi , HORTON, Denise, Silvina, Piccini, Quintas , LEME, Ednilse , QUINTILIO, Wagner , SAKAUCHI, Maria, Aparecida , PRADO, Sally Muller Affonso , MENDES, Elizabeth , HIGASHI, Hisako, Gondo
IPC分类号： A61K39/10
CPC分类号： A61K39/099 , A61K2039/521 , C12N1/06 , C12N1/20 , C12N1/36
摘要： process for obtention of new cellular pertussis vaccine, which foresees the use of Bordetella pertussis cells, obtained by culture in fermentation unit, detoxified by formaldehyde, which after treatment with organic solvent originate vaccine preparations that are less toxic and as potent as the traditional pertussis cellular vaccine.
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公开(公告)号：EP2970880B1
公开(公告)日：2022-05-04
申请号：EP14765285.3
申请日：2014-03-15
发明人： KERKIS, Irina , GLOZMAN, Sabina
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公开(公告)号：EP3604329A1
公开(公告)日：2020-02-05
申请号：EP18771889.5
申请日：2018-03-21
申请人： Fundação Butantan
摘要： This invention falls within the fields of biochemistry, molecular biology, genetics, pharmacy and medicinal chemistry, being related to biochemical and metabolic processes. More specifically, the present invention provides a novel class of proteins that inhibit thrombin, particularly direct inhibitors of thrombin modified from sculptin, identified in the transcriptomics analysis of the salivary glands of ticks, as well as fragments and recombinant protein thereof, which can be used as anticoagulant agents and for the prophylaxis and/or treatment of thromboembolic diseases.
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10.发明公开
公开(公告)号：EP3426267A1
公开(公告)日：2019-01-16
申请号：EP17712549.9
申请日：2017-03-09
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