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396 条记录 (耗时 0.033 秒)

    SELECTION OF CELLS EXPRESSING HETEROMERIC POLYPEPTIDES
    1.
    发明授权
    SELECTION OF CELLS EXPRESSING HETEROMERIC POLYPEPTIDES 有权

    公开(公告)号：EP3187592B1

    公开(公告)日：2018-12-12

    申请号：EP16200934.4

    申请日：2002-09-20

    申请人： Immunex Corporation

    发明人： MCGREW, Jeffrey, T. ,  BIANCHI, Allison, A.

    IPC分类号： C12P21/08 ,  C12Q1/68 ,  C07K16/28 ,  C12N15/62

    CPC分类号： C07K16/2866 ,  C07K2319/00 ,  C07K2319/73 ,  C12N15/62

    摘要： The present invention relates to the general field of recombinant expression of polypeptides in animal cell culture. More particularly, the invention concerns improved selection in cells of recombinantly engineered vectors designed to express polypeptides. It relates more specifically to a method of producing and isolating a heteromeric immunoglobulin heavy and light chain complex, the method comprising transfecting cells with a vector comprising a first nucleic acid encoding a first immunoglobulin heavy or light chain, wherein the transcription of said first nucleic acid is operably linked to transcription of a second nucleic acid encoding a first subunit of a selectable marker, and further comprising a third nucleic acid encoding a second immunoglobulin light or heavy chain wherein the immunoglobulin light and heavy chains are capable of associating to form a heteromeric complex, wherein the transcription of said third nucleic acid is operably linked to transcription of a fourth nucleic acid which encodes a second subunit of a selectable marker, and wherein said second and first subunit of the selectable marker associate, to provide a selectable activity, and applying selection to the cells.

    Use of interleukin-4 antibodies and compositions thereof
    3.
    发明授权
    Use of interleukin-4 antibodies and compositions thereof 有权
    Verwendung von Interleukin-4Antikörperund deren Zusammensetzungen

    公开(公告)号：EP2292665B1

    公开(公告)日：2015-07-08

    申请号：EP10185626.8

    申请日：2001-05-25

    申请人： Immunex Corporation

    发明人： Pluenneke, John D ,  Armitage, Richard J ,  Escobar, Jose Carlos ,  Morris, Arvia E

    IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P19/02 ,  A61P31/04 ,  C07K14/715

    CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/395 ,  A61K2039/505 ,  C07K14/7155 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

    摘要： The present invention provides an antibody that competes for binding with a reference antibody to human IL-4 receptor (IL-4R), wherein the light chain of the reference antibody comprises the sequence of SEQ ID NO: 10 and the heavy chain of the reference antibody comprises the sequence of SEQ ID NO:12; or the light chain of the reference antibody comprises the sequence of SEQ ID NO:14 and the heavy chain of the reference antibody comprises the sequence of SEQ ID NO:16 or the light chain of the reference antibody comprises the sequence of SEQ ID NO:18 and the heavy chain of the reference antibody comprises the sequence of SEQ ID NO:20 or the light chain of the reference antibody comprises the sequence of SEQ ID NO:22 and the heavy chain of the reference antibody comprises the sequence of SEQ ID NO:24 and uses thereof.

    摘要翻译： 本发明提供了竞争与参考抗体与人IL-4受体（IL-4R）结合的抗体，其中参考抗体的轻链包含SEQ ID NO：10的序列和参考的重链 抗体包含SEQ ID NO：12的序列; 或参照抗体的轻链包含SEQ ID NO：14的序列，并且参考抗体的重链包含SEQ ID NO：16的序列或参照抗体的轻链包含SEQ ID NO： 18，并且参考抗体的重链包含SEQ ID NO：20的序列，或者参考抗体的轻链包含SEQ ID NO：22的序列，并且参考抗体的重链包含SEQ ID NO： ：24及其用途。