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公开(公告)号：EP1183362B1
公开(公告)日：2006-12-27
申请号：EP00936300.3
申请日：2000-05-25
申请人： IMMUNEX CORPORATION
发明人： SIMS, John, E. , RENSHAW, Blair, R.
IPC分类号： C12N15/25 , C07K14/545 , C07K16/24
CPC分类号： C07K14/545
摘要： The invention is directed to novel, purified and isolated IL-1 eta polypeptides and fragments thereof, the polynucleotides encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and uses thereof.
摘要翻译： 本发明涉及新的，纯化的和分离的IL-1eta多肽及其片段，编码这些多肽的多核苷酸，用于生产这种多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽以及用途 它们。
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公开(公告)号：EP1450837A2
公开(公告)日：2004-09-01
申请号：EP02759279.9
申请日：2002-08-07
申请人： IMMUNEX CORPORATION
发明人： SIMS, John, E. , SMITH, Dirk, E.
IPC分类号： A61K38/00
CPC分类号： A61K38/1793 , A61K38/20 , A61K45/06 , A61K2300/00
摘要： The invention pertains to methods for treating medical disorders characterized by elevated levels or abnormal expression of IL-1 by administering an IL-1 antagonist, such as soluble type II IL-1 receptor and/or IL-1RacP.
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公开(公告)号：EP1129190A1
公开(公告)日：2001-09-05
申请号：EP99960372.3
申请日：1999-11-12
申请人： IMMUNEX CORPORATION
IPC分类号： C12N15/12 , C12N5/10 , C07K14/475 , C07K16/22 , A61K38/18
CPC分类号： C07K14/52 , A61K38/00 , C07K14/475 , C07K14/5418 , C07K16/24 , C12N5/0636
摘要： The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
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4.发明授权IL-1/TNF-ALPHA-ACTIVATED KINASE (ITAK), AND METHODS OF MAKING AND USING THE SAME 失效IL-1 / TNF-ALPHA-活化激酶（ITAK），及其制备方法和使用
公开(公告)号：EP0914451B1
公开(公告)日：2006-07-12
申请号：EP97928639.0
申请日：1997-06-09
申请人： IMMUNEX CORPORATION
CPC分类号： C12N9/1205 , C07K2319/00
摘要： Purified and isolated IL-1/TNF-α-activated kinase (ITAK), nucleic acids encoding ITAK, processes for production of recombinant forms of ITAK, pharmaceutical compositions containing ITAK, and use of ITAK in therapies and in various assays, including assays to detect antagonists and agonists of ITAK are provided.
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5.发明授权IL-1 ZETA, IL-1 ZETA SPLICE VARIANTS AND XREC2 DNAS AND POLYPEPTIDES 有权IL-1ZETA，IL-1ZETA剪接变体，以及Xrec2 DNAS和多肽
公开(公告)号：EP1141298B1
公开(公告)日：2006-07-05
申请号：EP99966182.0
申请日：1999-12-14
申请人： IMMUNEX CORPORATION
IPC分类号： C12N15/25 , C12N15/12 , C07K14/545 , C07K14/705 , C07K16/24 , C12N5/10 , C12Q1/68
CPC分类号： C07K14/545 , C07K14/7155 , C07K2319/00
摘要： The invention is directed to novel, purified and isolated IL-1 zeta, IL-1 zeta splice variants, and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and uses thereof.
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公开(公告)号：EP1282435A2
公开(公告)日：2003-02-12
申请号：EP01933326.9
申请日：2001-05-11
申请人： IMMUNEX CORPORATION
CPC分类号： A61K38/1793 , Y02A50/411
摘要： The invention pertains to methods for treating medical disorders characterised by elevated levels or abnormal expression of IL-1 by administering and IL-1 antagonist, such as antibody directed against IL-1R.
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公开(公告)号：EP1049777A1
公开(公告)日：2000-11-08
申请号：EP99903320.2
申请日：1999-01-22
申请人： IMMUNEX CORPORATION
发明人： SIMS, John, E. , BORN, Teresa, L.
IPC分类号： C12N15/12 , C12N15/62 , C07K14/715 , C07K19/00 , C07K16/28
CPC分类号： A61B5/415 , A61B5/417 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
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公开(公告)号：EP1007537B1
公开(公告)日：2007-08-01
申请号：EP97905729.6
申请日：1997-02-06
申请人： IMMUNEX CORPORATION
发明人： PARNET, Patricia , SIMS, John, E.
IPC分类号： C07H21/04 , C12P21/06 , C12P21/02 , C12P21/08 , C12N1/20 , C12N15/00 , C07K1/00 , C07K14/705 , C07K14/52 , A61K45/00 , A61K39/395
CPC分类号： C07K14/705 , A61K38/00
摘要： 2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting prostaglandin synthesis and treating inflammation.
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9.发明公开IL-1/TNF-ALPHA-ACTIVATED KINASE (ITAK), AND METHODS OF MAKING AND USING THE SAME 失效IL-1 / TNF-ALPHA-活化激酶（ITAK），及其制备方法和使用
公开(公告)号：EP0914451A1
公开(公告)日：1999-05-12
申请号：EP97928639.0
申请日：1997-06-09
申请人： IMMUNEX CORPORATION
CPC分类号： C12N9/1205 , C07K2319/00
摘要： Purified and isolated IL-1/TNF-α-activated kinase (ITAK), nucleic acids encoding ITAK, processes for production of recombinant forms of ITAK, pharmaceutical compositions containing ITAK, and use of ITAK in therapies and in various assays, including assays to detect antagonists and agonists of ITAK are provided.
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公开(公告)号：EP1129190B2
公开(公告)日：2017-01-11
申请号：EP99960372.3
申请日：1999-11-12
申请人： Immunex Corporation
IPC分类号： C12N15/12 , C12N5/10 , C07K14/475 , C07K16/22 , A61K38/18
CPC分类号： C07K14/52 , A61K38/00 , C07K14/475 , C07K14/5418 , C07K16/24 , C12N5/0636
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