-
公开(公告)号：EP1317271A4
公开(公告)日：2005-06-29
申请号：EP01963360
申请日：2001-09-05
发明人： ILAN NETA , VLODAVSKY ISRAEL , YACOBY-ZEEVI ORON , PECKER IRIS
-
公开(公告)号：EP1317271A2
公开(公告)日：2003-06-11
申请号：EP01963360.1
申请日：2001-09-05
摘要： Methods and compositions for inducing and/or accelerating wound healing and/or angiogenesis via the catalytic activity of heparanase are disclosed.
-
3.发明公开POLYNUCLEOTIDE ENCODING A POLYPEPTIDE HAVING HEPARANASE ACTIVITY AND EXPRESSION OF SAME IN TRANSDUCED CELLS 有权编码多肽的多核苷酸在转导细胞中具有乙酰肝素酶活性和表达的多核苷酸
公开(公告)号：EP0998569A1
公开(公告)日：2000-05-10
申请号：EP98943469.1
申请日：1998-08-31
申请人： Insight Strategy & Marketing Ltd. , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , Friedman, Mark M.
CPC分类号： C12Y302/01166 , A61K38/00 , A61L27/34 , A61M15/009 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, transduced cells expressing heparanase and a recombinant protein having heparanase activity.
摘要翻译： 编码具有乙酰肝素酶活性的多肽的多核苷酸（hpa），包含其的载体，表达乙酰肝素酶的转导细胞和具有乙酰肝素酶活性的重组蛋白质。
-
4.发明公开THE USE OF ECM DEGRADING ENZYMES FOR THE IMPROVEMENT OF CELL TRANSPLANTATION 审中-公开细胞外基质降解酶在改善细胞移植中的应用
公开(公告)号：EP1379139A2
公开(公告)日：2004-01-14
申请号：EP01271434.1
申请日：2001-12-17
发明人： YACOBY-ZEEVI, Oron
IPC分类号： A01N63/00
CPC分类号： C12Y302/0105 , A61K38/00 , A61K2035/122 , A61K2035/124 , C12N9/2402 , C12Y302/01035 , C12Y302/01128 , C12Y302/01166
摘要： Cell preparations which comprise cells carrying an extracellular matrix degrading enzyme and methods of using such cell preparations for improving transplantation efficiency of such cells.
摘要翻译： 包含携带细胞外基质降解酶的细胞的细胞制剂以及使用这种细胞制剂提高这些细胞的移植效率的方法。
-
5.发明公开POLYNUCLEOTIDE ENCODING A POLYPEPTIDE HAVING HEPARANASE ACTIVITY AND EXPRESSION OF SAME IN GENETICALLY MODIFIED CELLS 审中-公开多核苷酸编码具有遗传修饰的细胞乙酰肝素酶AKTIVäT码及其表达多肽，
公开(公告)号：EP1157118A1
公开(公告)日：2001-11-28
申请号：EP00907262.0
申请日：2000-02-14
CPC分类号： C12Y302/01166 , A61K38/00 , C12N9/2402
摘要： A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
-
6.发明公开METHOD OF SCREENING FOR POTENTIAL ANTI-METASTATIC AND ANTI-INFLAMMATORY AGENTS USING MAMMALIAN HEPARANASE AS A PROBE 审中-公开筛选方法，潜在的抗METASTASISCHE-和抗炎剂使用哺乳动物乙酰肝素酶为探针
公开(公告)号：EP1097241A1
公开(公告)日：2001-05-09
申请号：EP99932382.7
申请日：1999-07-12
发明人： BEN-ARTZI, Hanna , AYAL-HERSHKOVITZ, Maty , VLODAVSKY, Israel , PECKER, Iris , PELEG, Yoav , MIRON, Daphna
CPC分类号： C12Y302/01166 , A61K38/00 , A61L27/34 , C12N9/2402 , C12Q1/34 , C12Q1/527 , G01N2333/924 , G01N2333/988 , G01N2400/40 , G01N2500/20
摘要： Qualitative and quantitative methods of testing an agent for its potential at inhibiting glycosidase catalytic activity, the methods including the steps of interacting a glycosidase enzyme with a glycosidase substrate in a presence of the agent and qualitatively or quantitatively evaluating an effect of the agent on the catalytic activity of the glycosidase enzyme toward the glycosidase substrate. Preferably the glycosidase enzyme is a heparanase enzyme and the glycosidase substrate is, respectively, a heparanase substrate.
-
7.发明公开
公开(公告)号：EP1379139A4
公开(公告)日：2004-12-01
申请号：EP01271434
申请日：2001-12-17
发明人： YACOBY-ZEEVI ORON
IPC分类号： C12N5/06 , A61K35/12 , A61K35/14 , A61K35/28 , A61K38/11 , A61K48/00 , A61P19/00 , C12N5/08 , C12N9/24 , A61K38/46 , A01N63/00
CPC分类号： C12Y302/0105 , A61K38/00 , A61K2035/122 , A61K2035/124 , C12N9/2402 , C12Y302/01035 , C12Y302/01128 , C12Y302/01166
摘要： Cell preparations which comprise cells carrying an extracellular matrix degrading enzyme and methods of using such cell preparations for improving transplantation efficiency of such cells.
-
8.发明公开
公开(公告)号：EP1126878A4
公开(公告)日：2003-04-16
申请号：EP99956781
申请日：1999-10-28
发明人： PERETZ TUVIA , MIRON DAPHNA , SHLOMI YINON , PECKER IRIS , AYAL-HERSHKOVITZ MATY , FRIEDMAN YAEL , VLODAVSKY ISRAEL
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07K16/40 , C12N5/10 , C12N9/24 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/15 , G01N33/573 , G01N33/577 , A61K38/47
CPC分类号： C07K16/40 , A61K38/00 , A61K2039/505 , C12N9/2402 , C12Y302/01166 , G01N33/573 , G01N2333/988 , G01N2400/40
-
公开(公告)号：EP1159409A1
公开(公告)日：2001-12-05
申请号：EP00908565.5
申请日：2000-02-10
发明人： YACOBY-ZEEVI, Oron
CPC分类号： A01K67/0271 , A61K9/0073 , A61K35/12 , A61K38/465 , A61K38/486 , A61K38/4886 , A61K38/51 , A61K48/00 , A61M15/009 , C12N9/2402 , C12Y302/01128 , C12Y302/01166 , G06K9/6282 , A61K2300/00 , A61K38/00
摘要： A method of inducing bone formation in a subject in need thereof, the method comprises administering to the subject a therapeutically effective amount of heparanase. A pharmaceutical composition for inducing bone formation in a subject in need thereof, the pharmaceutical composition comprises, as an active ingredient, a therapeutically effective amount of heparanase, and a pharmaceutically acceptable carrier.
-
10.发明公开GENETICALLY MODIFIED CELLS AND METHODS FOR EXPRESSING RECOMBINANT HEPARANASE AND METHODS OF PURIFYING SAME 审中-公开遗传修饰的细胞和方法表达重组乙酰肝素酶及其清洗
公开(公告)号：EP1076689A1
公开(公告)日：2001-02-21
申请号：EP99920135.3
申请日：1999-04-29
发明人： BEN-ARTZI, Hanna , AYAL-HERSHKOVITZ, Maty , YACOBY-ZEEVI, Oron , PECKER, Iris , PELEG, Yoav , SHLOMI, Yinon , MIRON, Daphna , GILBOA, Ayelet , MIMON, Madelene , FRIEDMAN, Mark, M.
CPC分类号： C12Y302/01166 , A61K38/00 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.018 秒)
