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125 条记录 (耗时 0.013 秒)

    METHOD FOR CRYSTALLIZATION OF 2-AMINO-2-Ý2-Ý4-(3- BENZYLOXYPHENYLTHIO)-2-CHLOROPHENYL¨ETHYL¨-1,3-PROPANEDIOL HYDROCHLORIDE
    9.
    发明公开
    METHOD FOR CRYSTALLIZATION OF 2-AMINO-2-Ý2-Ý4-(3- BENZYLOXYPHENYLTHIO)-2-CHLOROPHENYL¨ETHYL¨-1,3-PROPANEDIOL HYDROCHLORIDE 有权
    VERFAHREN ZUR KRISTALLISIERUNG VON 2-AMINO-2-| 2-| 4-（3-苄氧基苯基）-2-氯苯基乙基-1,3-丙二醇氯仿

    公开(公告)号：EP2269982A4

    公开(公告)日：2014-03-12

    申请号：EP09724232

    申请日：2009-03-18

    申请人： KYORIN SEIYAKU KK

    发明人： KOMATSU HIDETAKA ,  SATOH HIROYA

    IPC分类号： C07C319/28 ,  C07C323/32

    CPC分类号： C07C319/28 ,  C07B2200/13 ,  C07C323/32

    摘要： The present invention herein provides a method for highly efficiently preparing high purity crystals of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-ethyl]-1,3-propanediol hydrochloride. The method comprises the following steps: (1) dissolving 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol in a mixed solvent comprising a solvent in which the compound in the form of the hydrochloride thereof is highly soluble and a solvent in which the compound in its hydrochloride is less soluble, to thus prepare a solution of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol; and then (2) adding hydrochloric acid to the resultant solution with stirring, to thus crystallize the hydrochloride of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol.

    摘要翻译： 本发明提供了高效制备2-氨基-2- [2- [4-（3-苄氧基苯硫基）-2-氯苯基] - 乙基] -1,3-丙二醇盐酸盐的高纯度晶体的方法。 该方法包括以下步骤：（1）将2-氨基-2- [2-（4-（3-苄氧基苯硫基）-2-氯苯基]乙基] -1,3-丙二醇溶于包含其中的溶剂的混合溶剂中， 其盐酸盐形式的化合物是高度可溶的，其中其盐酸盐中的化合物较不溶解的溶剂，从而制备2-氨基-2- [2- [4-（3-苄氧基苯硫基） - 2-氯苯基]乙基] -1,3-丙二醇; 然后（2）在搅拌下向所得溶液中加入盐酸，从而使2-氨基-2- [2- [4-（3-苄氧基苯硫基）-2-氯苯基]乙基] -1,3- 丙二醇。

    METHOD FOR PRODUCING 3,4-DISUBSTITUTED PYRROLIDINE DERIVATIVE
    10.
    发明公开
    METHOD FOR PRODUCING 3,4-DISUBSTITUTED PYRROLIDINE DERIVATIVE 审中-公开
    用于生产3,4-二取代吡咯烷

    公开(公告)号：EP2634172A4

    公开(公告)日：2014-01-29

    申请号：EP11836226

    申请日：2011-10-24

    申请人： KYORIN SEIYAKU KK

    发明人： ARAYA ICHIRO ,  KIYOTA KOICHI ,  NAGAO MUNEKI

    IPC分类号： C07D207/24 ,  C07B53/00 ,  C07B61/00 ,  C07C269/06

    CPC分类号： C07D207/24 ,  C07B53/00 ,  C07C227/18 ,  C07C269/06 ,  C07C2601/02 ,  C07D207/16 ,  C07D207/277 ,  Y02P20/55 ,  C07C271/22

    摘要： The present invention provides an inexpensive and industrially advantageous method for producing an optically active form of an anti-(3S,4R)-3-alkylcarbamoyl-4-hydroxypyrrolidine derivative or it's enantiomer, which is a key intermediate for producing a high-quality optically active form of (3R,4S)-3-alkylaminomethyl-4-fluoropyrrolidine or it's enantiomer useful as an intermediate for producing pharmaceuticals. The present invention relates to a method for producing an optically active anti-(3S,4R)-4-hydroxypyrrolidine-3-carboxamide derivative, or it's enantiomer by carrying out asymmetric hydrogenation using an optically active catalyst of a 4-oxopyrrolidine-3-carboxamide derivative represented by the general formula (I). [in the formula (I), PG 1 represents a protective group for an amino group, and R 1 represents hydrogen, a C1 to C6 alkyl group which may be substituted, or a C3 to C8 cycloalkyl group which may be substituted].