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    METHOD OF MANUFACTURING GAS BARRIER FILM COATED PLASTIC CONTAINER
    1.
    发明公开
    METHOD OF MANUFACTURING GAS BARRIER FILM COATED PLASTIC CONTAINER 审中-公开
    VERFAHREN ZUR HERSTELLUNG EINES MIT EINEM GASBARRIEREFILM BESCHICHTETENKUNSTSTOFFBEHÄLTERS

    公开(公告)号：EP1652961A1

    公开(公告)日：2006-05-03

    申请号：EP04747572.8

    申请日：2004-07-15

    申请人： MITSUBISHI SHOJI PLASTICS CORPORATION ,  Youtec Co. Ltd. ,  Kirin Brewery Company, Ltd.

    发明人： TAKEMOTO, Keishu ,  KAGE, Tsuyoshi ,  KOBAYASHI, Takumi ,  SHIRAKURA, Akira

    IPC分类号： C23C16/02 ,  C23C16/509 ,  B65D23/02

    CPC分类号： C23C16/045

    摘要： A method of manufacturing a gas barrier film coated plastic container with high gas-barrier properties by solving a problem in a conventional method wherein the formation of a gas barrier film is obstructed by water molecules adsorbed in the plastic container and the container with reduced gas-barrier properties is manufactured. The method is characterized by comprising the steps of decreasing a pressure inside the plastic container or decreasing a pressure to the entire part of the plastic container, flowing dry gas as leak gas when vacuum is released to fill the inside of the container with the dry gas for drying the plastic container, replacing the gas inside the plastic container with a material gas or a material gas-containing gas, and plasmatizing the material gas to form the gas barrier film on the inner surface of the plastic container by a CVD method.

    摘要翻译： 通过解决常规方法中的阻气膜的形成被吸附在塑料容器中的水分子和具有降低气体阻挡层的容器阻碍的常规方法的问题，制造具有高阻气性的阻气膜涂覆塑料容器的方法， 制造阻隔性能。 该方法的特征在于包括以下步骤：减小塑料容器内部的压力或降低塑料容器的整个部分的压力，当释放真空时将干燥气体作为泄漏气体流动，以用干燥气体填充容器的内部 用于干燥塑料容器，用原料气体或含原料气体的气体代替塑料容器内部的气体，并通过CVD方法在材料气体的等离子体化处理以在塑料容器的内表面上形成阻气膜。

    METHOD FOR ACTIVATING HUMAN ANTIGEN PRESENTING CELLS, ACTIVATED HUMAN ANTIGEN PRESENTING CELLS, AND USE OF THE SAME
    3.
    发明公开
    METHOD FOR ACTIVATING HUMAN ANTIGEN PRESENTING CELLS, ACTIVATED HUMAN ANTIGEN PRESENTING CELLS, AND USE OF THE SAME 失效
    方法激活人力，抗原活化细胞活化的人，抗原活化细胞及其用途

    公开(公告)号：EP0957161A1

    公开(公告)日：1999-11-17

    申请号：EP97949237.8

    申请日：1997-12-25

    申请人： Kirin Brewery Company, Ltd.

    发明人： KOEZUKA, Y. Kirin Brewery Company, Ltd. ,  YAMAGUCHI, Y. Kirin Brewery Company, Ltd ,  MOTOKI, K. Kirin Brewery Company, Ltd.

    IPC分类号： C12N5/22 ,  C07H15/04 ,  A61K35/14 ,  A61K35/28 ,  A61K35/36

    CPC分类号： C07H15/04 ,  A61K2039/5154 ,  C12N5/0639 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/90

    摘要： A method for activating human antigen presenting cells characterized by culturing in vitro antigen presenting cells with a human origin together with at least one of glycoside compounds represented by general formula (A) or salts thereof preferably exemplified by (2S, 3S, 4R)-1-(α-D-galactopyranosyloxy)-2-hexacosanoylamino-3,4-octadecanediol; the human antigen presenting cells thus activated; methods for treating cancer or infectious diseases such as AIDS by using activated human antigen presenting cells; and the use of activated human antigen presenting cells in the production of drugs for treating these diseases. Thus, sufficient therapeutic effects can be achieved on cancer and infectious diseases such as AIDS without effecting any pulse therapy with the use of tumor antigens.

    摘要翻译： 一种用于激活通过在体外培养的抗原与由通式（A）代表的糖苷化合物中的至少一种呈递细胞与人源一起表征的人抗原呈递细胞或其盐优选通过（2S，3S，4R）例举方法-1 - （α-D-半乳糖吡喃糖基）-2-二十六烷基-3,4-十八烷二醇; 人抗原呈递细胞如此活化; 方法用于治疗癌症或感染性疾病：通过使用活化的人的抗原呈递细胞，如艾滋病; 并在生产药物的用途激活的人体的抗原呈递细胞用于治疗疾病的论文。 因此，足够的治疗效果可在癌症和感染性疾病来实现：例如AIDS，而不会影响任何脉冲疗法与使用肿瘤抗原。

    DLC FILM COATED PLASTIC CONTAINER, AND DEVICE AND METHOD FOR MANUFACTURING THE PLASTIC CONTAINER
    8.
    发明公开
    DLC FILM COATED PLASTIC CONTAINER, AND DEVICE AND METHOD FOR MANUFACTURING THE PLASTIC CONTAINER 有权
    Vorrichtung zur Beschichtung einesKunststoffbehältersmit einerdiamantähnlichenKohlenstoffschicht

    公开(公告)号：EP1508525A1

    公开(公告)日：2005-02-23

    申请号：EP03733060.2

    申请日：2003-05-26

    申请人： Kirin Brewery Company, Ltd.

    发明人： YAMASAKI, Teruyuki, KIRIN BREWERY COMPANY, LTD. ,  SHIRAKURA, Akira, KIRIN BREWERY COMPANY, LTD. ,  ANDO, Hideyasu, KIRIN BREWERY COMPANY, LTD.

    IPC分类号： B65D23/02 ,  C23C16/26

    CPC分类号： C23C16/26 ,  B65D1/0215 ,  B65D23/0814 ,  C23C16/045 ,  C23C16/505 ,  Y10T428/1352

    摘要： The present invention provides a plastic container having a inner wall surface coated with DLC film which has same level of oxygen barrier property as prior art and can prevent a coloring of the DLC film formed on a neck portion of the container, manufacturing apparatus therefor and manufacturign method thereof.
    The apparatus for manufacturing the DLC film coated plastic container, comprising: a container side electrode which forms one portion of a pressure-reducing chamber which houses a container formed from plastic, a facing electrode which faces said container side electrode and is arranged inside said container or above said opening, wherein said container side electrode and said facing electrode are made to face each other via an insulating body which forms a portion of said pressure-reducing chamber, source gas supply means which includes a supply gas inlet pipe, exhaust means, and high frequency supply means; wherein said container side electrode is formed so that the average inner hole diameter of the inner wall surrounding said neck portion when the container is housed becomes smaller than the average inner hole diameter of the inner wall surrounding said body portion, and the average distance between the outer wall of said container and the inner wall of said container side electrode in a horizontal cross section with respect to the vertical direction of said container at said neck portion becomes longer than the average distance between the outer wall of said container and the inner wall of said container side electrode in a horizontal cross section with respect to the vertical direction of said container at said body portion.

    摘要翻译： 本发明提供了一种塑料容器，其具有涂覆有DLC膜的内壁表面，其具有与现有技术相同的氧阻隔性能，并且可以防止形成在容器的颈部上的DLC膜的着色，其制造装置和制造 方法。 ＆lt; D＆gt;用于制造DLC薄膜包衣的塑料容器的装置包括：容器侧电极，其形成容纳由塑料形成的容器的减压室的一部分;面向所述容器侧电极的面对电极， 布置在所述容器内或所述开口上方，其中所述容器侧电极和所述面对电极经由形成所述减压室的一部分的绝缘体彼此面对，源气体供应装置包括供给气体入口管 排气装置和高频供给装置; 其特征在于，所述容器侧电极被形成为使得当容纳容器时围绕所述颈部的内壁的平均内孔直径小于围绕所述主体部分的内壁的平均内孔直径， 所述容器的外壁和所述容器侧电极的内壁在所述颈部处相对于所述容器的垂直方向呈水平截面，变得比所述容器的外壁和所述容器的外壁之间的平均距离 所述容器侧电极在所述主体部分处于相对于所述容器的垂直方向的水平横截面。

    Protein having TPO activity
    10.
    发明公开
    Protein having TPO activity 失效
    蛋白质TPO-Aktivität。

    公开(公告)号：EP0668352A1

    公开(公告)日：1995-08-23

    申请号：EP95200385.3

    申请日：1995-02-14

    申请人： Kirin Brewery Company, Ltd.

    发明人： Miyazaki, Hiroshi ,  Kato, Takashi ,  Ohgami, Kinya ,  Iwamatsu, Akihiro ,  Akahori, Hiromichi ,  Kuroki, Ryota ,  Shimizu, Toshiyuki ,  Muto, Takanori

    IPC分类号： C12N15/19 ,  C07K14/52 ,  C07K16/24 ,  A61K38/19

    CPC分类号： C07K14/524 ,  A61K38/00

    摘要： The present invention relates to thrombopoietin (TPO) polypeptides having the biological activity of specifically stimulating or increasing platelet production comprising the amino acid sequence 1-332 of SEQ ID NO: 6 or a derivative thereof, DNA molecules encoding TPO polypeptides, processes for production of the polypeptides, antibodies specifically immunoreactive with the polypeptides, pharmaceutical compositions comprising the polypeptides, and methods for using the polypeptides in treatment of platelet disorders such a thrombocytopenia.

    摘要翻译： 本发明涉及具有特异性刺激或增加血小板产生的生物活性的血小板生成素（TPO）多肽，其包含SEQ ID NO：6的氨基酸序列1-332或其衍生物，编码TPO多肽的DNA分子， 多肽，与多肽特异性免疫反应的抗体，包含多肽的药物组合物，以及使用该多肽治疗血小板减少症如血小板减少症的方法。