CHLORELLA PREPARATIONS EXHIBITING IMMUNOMODULATING PROPERTIES
    5.
    发明授权
    CHLORELLA PREPARATIONS EXHIBITING IMMUNOMODULATING PROPERTIES 无效
    筹备小球藻免疫调节性能

    公开(公告)号:EP1307213B1

    公开(公告)日:2004-04-28

    申请号:EP01966835.9

    申请日:2001-08-09

    IPC分类号: A61K35/80 A61P37/02

    摘要: Chlorella extracts containing high molecular weight Chlorella polysaccharide and polysaccharide complexes show immune modulatory, specifically immune stimulatory, activity. The polysaccharide and polysaccharide complexes contain glucose and any combination of: galactose, rhamnose, mannose and arabinose, as well as N-acetyl glucosamine and N-acetyl galactosamine. The extracts may be treated with pronase, DNAse, RNAse and proteases to remove unassociated nucleic acids, ribonucleic acids and proteins. The extracts may also undergo treatment to effect cleavage of specific glycosidic linkages, the linkages being defined by their susceptibility to cleavage by amylase, amyloglucosidase, cellulase or neuraminidase. Chlorella extracts may be administered to a mammal to increase proliferation of splenocytes and increase production of cytokines such as IL-6, IL-10, INF-η and TNF-α. They may be used as a supplement to a vaccination regimen.

    CHLORELLA PREPARATIONS EXHIBITING IMMUNOMODULATING PROPERTIES
    6.
    发明公开
    CHLORELLA PREPARATIONS EXHIBITING IMMUNOMODULATING PROPERTIES 无效
    筹备小球藻免疫调节性能

    公开(公告)号:EP1307213A2

    公开(公告)日:2003-05-07

    申请号:EP01966835.9

    申请日:2001-08-09

    IPC分类号: A61K35/80 A61P37/02

    摘要: Chlorella extracts containing high molecular weight Chlorella polysaccharide and polysaccharide complexes show immune modulatory, specifically immune stimulatory, activity. The polysaccharide and polysaccharide complexes contain glucose and any combination of: galactose, rhamnose, mannose and arabinose, as well as N-acetyl glucosamine and N-acetyl galactosamine. The extracts may be treated with pronase, DNAse, RNAse and proteases to remove unassociated nucleic acids, ribonucleic acids and proteins. The extracts may also undergo treatment to effect cleavage of specific glycosidic linkages, the linkages being defined by their susceptibility to cleavage by amylase, amyloglucosidase, cellulase or neuraminidase. Chlorella extracts may be administered to a mammal to increase proliferation of splenocytes and increase production of cytokines such as IL-6, IL-10, INF-η and TNF-α. They may be used as a supplement to a vaccination regimen.