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1.发明公开UTILISATION D'EXTRAITS DE GINKGO BILOBA POUR PREPARER UN MEDICAMENT DESTINE A TRAITER LA SCLEROSE LATERALE AMYOTROPHIQUE 有权作者银杏叶提取物用于制备药物用于治疗肌萎缩性侧索硬化USE
公开(公告)号：EP1102586A1
公开(公告)日：2001-05-30
申请号：EP99936702.2
申请日：1999-08-06
发明人： CHRISTEN, Yves
IPC分类号： A61K31/365 , A61K35/78
CPC分类号： A61K31/425 , A61K31/365 , A61K31/44 , A61K36/16 , A61K2300/00
摘要： The invention concerns the use of Ginkgo biloba extracts, and in particular Ginkgo biloba extracts containing 20 to 30 % of flavoneglycosides, 2.5 to 4.5 % of ginkgolides A, B, C and J, 2 to 4 % of bilobalide, less than 10 % of proanthocyanidines and less than 10 ppm of compounds of the alkylphenol type, for preparing a medicine for treating amyotrophic lateral sclerosis.
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2.发明公开COMPLEXES METALLIQUES AVEC UN LIGAND TRIDENTATE COMME CATALYSEURS DE POLYMERISATION 失效WITH A TRIDENTATLIGAND作为聚合催化剂金属配合物
公开(公告)号：EP0998478A1
公开(公告)日：2000-05-10
申请号：EP98936450.0
申请日：1998-07-06
申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE
发明人： BERTRAND, Guy , CAZAUX, Jean-Bernard , FAURE, Jean-Luc , NGUYEN, Hanh,Cité Universitaire - Ponsan Bellevue , REAU, Régis
CPC分类号： C07F7/10 , C07F3/06 , C07F7/2284 , C08F4/16 , C08G63/823 , C08G65/10 , C08G65/266
摘要： The invention concerns novel compounds having the elements of group 11, 12 or 14 and a tridentate ligand, a method for preparing them and their use in particular as polymerisation catalyst.
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3.发明公开METHOD OF IDENTIFYING GINKO BILOBA IN A PLANT EXTRACT BY GENE PROFILING 审中-公开FOR银杏在植物体内检测方法提取由决定的遗传轮廓的
公开(公告)号：EP1292706A2
公开(公告)日：2003-03-19
申请号：EP01920817.2
申请日：2001-03-27
申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) , Georgetown University
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6809
摘要： The present invention is directed to a method of establishing an 'identity' of Ginkgo biloba leaves or isolated ginkgolide B (GKB) or another component of the extract of Ginkgo biloba leaves, by obtaining a 'gene regulation profile'. The invention is also directed to a method of verifying the identity of a Ginkgo biloba extract by comparing the gene regulation profile of a Gingko biloba extract of unknown or questionable origin with the gene regulation pofile of a Gingko biloba extract of known origin. The present invention is further directed to a method of establishing a gene expression profile of Ginkgolide A, Ginkgolide B or any other component isolated from a Ginkgo biloba extract, more particularly, from EGB 761®.
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4.发明公开
公开(公告)号：EP1240212A1
公开(公告)日：2002-09-18
申请号：EP00966257.8
申请日：2000-10-03
IPC分类号： C08F8/32 , C08B37/00 , C08F251/00 , C08K5/17 , A61K9/20
CPC分类号： C08G81/024 , A61K9/1652 , A61K9/205 , A61K9/286 , A61K9/5036 , C08B37/0069 , C08F251/00 , C08K5/16 , C08L5/08
摘要： The invention concerns crosslinked copolymers based on non-crosslinked polycarboxylic copolymers, said non-crosslinked copolymers containing at least a polysaccharide. The invention also concerns a method for preparing said copolymers and their use in particular as support in pharmaceutical compositions.
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5.发明公开PRODUIT COMPRENANT AU MOINS UNE SUBSTANCE INHIBITRICE DES NO SYNTHASES EN ASSOCIATION AVEC AU MOINS UNE SUBSTANCE INHIBITRICE DES PHOSPHOLIPASES A2 有权组合物中至少对一合酶抑制剂和至少一种磷脂酶A2抑制剂含有用于生产药物
公开(公告)号：EP1233786A2
公开(公告)日：2002-08-28
申请号：EP00974645.4
申请日：2000-11-03
IPC分类号： A61K45/06 , A61P3/00 , A61P9/00 , A61P11/00 , A61P17/00 , A61P19/00 , A61P25/00 , A61P27/00 , A61P29/00 , A61P31/00 , A61P33/00 , A61P35/00 , A61P37/00
CPC分类号： A61K45/06 , A61K31/343 , A61K31/416 , A61K31/427 , A61K31/473 , A61K2300/00
摘要： The invention concerns a product comprising at least a NO synthase inhibiting substance associated with at least a phospholipase A2 inhibiting substance, separately or combined, for simultaneous therapeutic use, separately or spread over time for treating pathologies in which nitrogen monoxide and/or phosplipases A2 are involved. The invention also concerns a pharmaceutical composition comprising, as active principle, at least a NO synthase inhibiting substance and at least a phospholipase A2 inhibiting substance, and optionally a pharmaceutically acceptable carrier.
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6.发明公开ACIDES NUCLEIQUES CODANT POUR DES PEPTIDES POSSEDANT L'ACTIVITE BIOLOGIQUE DE LA SORBINE 审中-公开核酸编码具有SORBINE活性的肽
公开(公告)号：EP1194552A1
公开(公告)日：2002-04-10
申请号：EP00953262.3
申请日：2000-07-19
申请人： INSTITUT NATIONAL DE LA SANTE ETDE LA RECHERCHE MEDICALE (INSERM) , SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
IPC分类号： C12N15/12 , C12N15/11 , C12Q1/68 , C07K14/47 , C07K16/18 , A61K38/17 , A61K48/00 , G01N33/53
摘要： The invention concerns nucleic acids coding for peptides having the biological activity of sorbin, the resulting coded peptides and their therapeutic uses, particularly the use of their properties on water and electrolyte cell absorption.
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7.发明公开UTILISATION D'INHIBITEURS DE PRENYLTRANSFERASES POUR PREPARER UN MEDICAMENT DESTINE A TRAITER LES PATHOLOGIES QUI RESULTENT DE LA FIXATION MEMBRANAIRE DE LA PROTEINE G HETEROTRIMERIQUE 审中-公开异戊二烯基抑制剂的制备用于疾病的治疗中药物的使用，通过固定MEMBRANISCHE HETEROTRIMERISCHE G蛋白ARISE
公开(公告)号：EP1094810A1
公开(公告)日：2001-05-02
申请号：EP99929396.2
申请日：1999-07-05
IPC分类号： A61K31/425 , A61K31/215 , A61K31/47 , A61K31/535 , A61K31/55 , A61K31/66 , A61K31/445 , A61K31/42 , A61K31/495
CPC分类号： A61K38/005 , Y02A50/471
摘要： The invention concerns the use of prenyltransferase inhibitors for preparing a medicine for treating pathologies resulting from prenylation of the η subunit of G protein. Said diseases comprise in particular diseases related to the following biological functions or disorders: smell, taste, light perception, neurotransmission, neurodegeneration, endocrine and exocrine gland functioning, autocrine and paracrine regulation, blood pressure, embryogenesis, viral infection, immunological functions, diabetes and obesity.
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8.发明公开
公开(公告)号：EP1066049A1
公开(公告)日：2001-01-10
申请号：EP99910418.5
申请日：1999-03-22
发明人： PELLET, Marc , BISMUTH, Frédéric
CPC分类号： A61K9/0024 , A61K9/14 , A61K9/19 , A61K38/09
摘要： The invention concerns novel solid or semi-solid pharmaceutical compositions comprising a soluble peptide salt capable of jellifying, having a high specific surface area. Said compositions can also comprise an excipient and/or water. Once injected to a patient, the compositions jellify and release the peptide salt for a long time interval not less than 15 days.
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9.发明公开ANALOGUES OPTIQUEMENT PURS DE LA CAMPTOTHECINE, INTERMEDIAIRE DE SYNTHESE OPTIQUEMENT PUR ET SON PROCEDE DE PREPARATION 有权光学PURE CAMPTOTHECINANALOGE，光学纯合成中间体和工艺及其
公开(公告)号：EP1007527A1
公开(公告)日：2000-06-14
申请号：EP98941567.4
申请日：1998-08-07
发明人： CAZAUX, Jean-Bernard , LAVERGNE, Olivier , LE BRETON, Christine , MANGINOT, Eric,Lotissement "Les Sabines" , BIGG, Dennis
IPC分类号： C07D491/22 , C07D491/04 , A61K31/435
CPC分类号： C07D491/04
摘要： The invention concerns novel camptothecin analogues and in particular products corresponding to the following formulae: (+)-5-ethyl-9, 10-difluoro-5-hydroxy-4, 5,13,15-tetrahydro-1H, 3H-oxepino[3',4':6, 7]indolizino[1,2-b] quinoline-3,15-dione; (+)-1-[9-chloro-5- ethyl-5-hydroxy-10-methyl-3, 15-dioxo-4,5,13, 15-tetrahydro-1H,3H-oxepinol[3' ,4':6,7]indolizino [1,2-b]quinoline-12-ylmethyl] -4-methyl-hexahydropyridinium chloride; their application as medicine, pharmaceutical compositions containing them and their use for producing antitumoral, antiviral or antiparasitic medicines. The invention also concerns a novel synthesis intermediate of said products and a method for preparing said intermediate.
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10.发明公开
公开(公告)号：EP0983287A1
公开(公告)日：2000-03-08
申请号：EP98925761.3
申请日：1998-05-20
发明人： VASELLA, Andrea , WEBER, Martin
CPC分类号： C07H17/04
摘要： The invention concerns novel glycosylated ginkgolide derivatives, their application as medicines and pharmaceutical compositions containing them. It also discloses a method for preparing said derivatives. In formula (I), W, X, Y and Z represent independently the radicals H, OH, linear or branched alkoxy or O-GS, GS-OH representing mono- or disaccharide, or one of their derivatives or analogs, with the proviso that at least one of W, X, Y or Z is a O-GS radical.
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