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    A PROCESS FOR THE GENERATION OF PROLIFERATING CD4 LYMPHOCYTES
    2.
    发明授权
    A PROCESS FOR THE GENERATION OF PROLIFERATING CD4 LYMPHOCYTES 失效
    产生增殖性CD4淋巴细胞的过程

    公开(公告)号：EP0460065B1

    公开(公告)日：1994-08-31

    申请号：EP90904107.1

    申请日：1990-02-08

    申请人： TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION

    发明人： LEUNG, Kam, Hung ,  TOWNSEND, Robert, Martin

    IPC分类号： C12N5/08 ,  A61K39/00 ,  A61K35/14 ,  C12Q1/70

    CPC分类号： C12N7/00 ,  A61K2039/5158 ,  C12N5/0636 ,  C12N2501/23 ,  C12N2740/16051

    摘要： Peripheral blood mononuclear cells (PBMC) or tumor infiltrating lymphocytes (TIL) are treated with a dipeptide alkyl ester such as leucyl leucine methyl ester (LLME) or with an amino acid alkyl ester such as leucine methyl ester (LME) to deplete monocytes and large granular lymphocytes, then cultured in media containing T-cell stimulant and interleukin-2 to generate and proliferate a lymphocyte population enriched in CD4+ lymphocytes.

    摘要翻译： 用二肽烷基酯例如亮氨酸亮氨酸甲酯（LLME）或用氨基酸烷基酯例如亮氨酸甲酯（LME）处理外周血单核细胞（PBMC）或肿瘤浸润淋巴细胞（TIL）以消耗单核细胞和大 然后在含有T细胞刺激剂和白细胞介素-2的培养基中培养以产生和增殖富含CD4 +淋巴细胞的淋巴细胞群。