公开(公告)号：EP4437465A1

公开(公告)日：2024-10-02

申请号：EP22899388.7

申请日：2022-11-23

申请人： GE Precision Healthcare LLC ,  The Board of Trustees of the Leland Stanford Junior University

发明人： PAL, Debashish ,  SHEN, Yaxi ,  NICHOLS, Steven ,  SINGH, Ravi Raj ,  CIANO, Amanda ,  CHOUDHURY, Arindam Dutta ,  LANGLOTZ, Curt ,  LOENING, Andreas ,  CHAUDHARI, Akshay ,  BAHRAMI, Naeim

IPC分类号： G06N20/00

CPC分类号： G06N20/00 ,  G16H40/20 ,  G16H70/20 ,  G06N5/04 ,  G16H30/40 ,  G16H40/67

公开(公告)号：EP4431607A2

公开(公告)日：2024-09-18

申请号：EP24185859.6

申请日：2017-09-08

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： FRASER, Hunter ,  SMITH, Zachery

IPC分类号： C12N15/63

CPC分类号： C12N15/102 ,  C12N15/63 ,  C12N15/90 ,  C12N15/113 ,  C12N2310/2020170501

摘要： The invention provides compositions and methods for high-efficiency genome editing. In some aspects, the invention provides retron-guide RNA cassettes and vectors comprising the cassettes. Also provided are host cells that have been transformed with the vectors. In other aspects, the invention provides retron donor DNA-guide molecules. In some other aspects, methods for genome editing and the screening of genetic loci are provided. In further aspects, methods and compositions are provided for the prevention or treatment of genetic diseases. Kits for genome editing and screening are also provided.

公开(公告)号：EP4429774A1

公开(公告)日：2024-09-18

申请号：EP22893917.9

申请日：2022-11-14

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： ZASLAVSKY, Maxim ,  BOYD, Scott D. ,  KUNDAJE, Anshul Bharat ,  TIBSHIRANI, Robert

IPC分类号： A61P37/02 ,  C07K14/005 ,  A61P37/06 ,  A61K39/00

CPC分类号： A61P37/02 ,  C07K14/705

公开(公告)号：EP4423267A1

公开(公告)日：2024-09-04

申请号：EP22888501.8

申请日：2022-10-27

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： LIN, Michael Z. ,  ZOU, Xinzhi ,  CHUNG, Hokyung

IPC分类号： C12N15/11 ,  C12N7/01 ,  C07K14/47 ,  C12N15/861

CPC分类号： C07K14/4702 ,  C07K2319/0020130101 ,  C07K2319/0220130101 ,  C07K2319/5020130101 ,  C12N9/48 ,  C12N15/625 ,  C07K14/535 ,  C07K14/71 ,  C07K2319/0320130101 ,  C12N15/86 ,  C12N2760/2024320130101 ,  C12N2760/2023220130101 ,  A61K35/768 ,  C12N2770/2422220130101

公开(公告)号：EP4349868A3

公开(公告)日：2024-08-28

申请号：EP23214925.2

申请日：2011-05-13

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： LIU, Jie ,  WEISSMAN, Irving L. ,  MAJETI, Ravindra

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/04

CPC分类号： C07K2317/2420130101 ,  C07K2317/7020130101 ,  C07K16/2803 ,  A61P35/00 ,  A61P35/02 ,  A61P37/04 ,  C07K2317/7620130101

摘要： Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies; and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies.

公开(公告)号：EP4365309A3

公开(公告)日：2024-08-21

申请号：EP24161425.4

申请日：2020-11-06

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Kurtz, David M. ,  Diehn, Maximilian ,  Alizadeh, Arash Ash

IPC分类号： C12Q1/6827 ,  C12Q1/6886 ,  G16B20/00 ,  C12Q1/6883

CPC分类号： G16B20/00 ,  C12Q1/6883 ,  C12Q2600/11220130101 ,  C12Q1/6827 ,  G16B30/00

摘要： Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.

公开(公告)号：EP3986941B1

公开(公告)日：2024-08-14

申请号：EP20827389.6

申请日：2020-06-19

IPC分类号： C08F212/08 ,  C08F220/06 ,  C08L25/08 ,  C08L33/02 ,  G01N33/487 ,  G01N33/92 ,  G01N33/68 ,  A61K9/51

CPC分类号： C08F212/08 ,  C08F2438/0320130101 ,  C08F220/06 ,  C08L25/08 ,  C08L33/02 ,  A61K9/5169

公开(公告)号：EP4408260A1

公开(公告)日：2024-08-07

申请号：EP22802410.5

申请日：2022-09-29

申请人： The Trustees Of The Stevens Institute Of Technology ,  Vanderbilt University ,  The Trustees of Columbia University in the City of New York ,  The Board of Trustees of the Leland Stanford Junior University

发明人： KIM, Jinho ,  VUNJAK-NOVAKOVIC, Gordana ,  O'NEILL, John D. ,  PINEZICH, Meghan ,  GUENTHART, Brandon A. ,  MIR, Seyed Mohammad ,  CHEN, Jiawen ,  BACCHETTA, Matthew

IPC分类号： A61B5/00 ,  G01N3/40 ,  G01N33/483

CPC分类号： A61B5/0055 ,  A61B5/6852 ,  A61B5/0053 ,  A61B5/6848 ,  A61B5/6853 ,  G01N33/4833 ,  G01N3/08 ,  G01N2203/007520130101 ,  G01N2203/008920130101

公开(公告)号：EP4405033A1

公开(公告)日：2024-07-31

申请号：EP22873581.7

申请日：2022-09-22

申请人： The Board of Trustees of the Leland Stanford Junior University ,  The University of North Carolina at Chapel Hill

发明人： DESIMONE, Joseph M. ,  JACOBSON, Gunilla B. ,  DULAY, Maria T. ,  LEE, Brian J. ,  HSIAO, Kai-Wen ,  RAJESH, Netra ,  DRISKILL, Madison M. ,  SHIH, Audrey ,  PERRY, Jillian ,  TIAN, Shaomin

IPC分类号： A61M37/00 ,  A61L31/06 ,  A61L31/16

CPC分类号： A61K9/0021 ,  A61M37/0015 ,  A61M2037/005320130101

公开(公告)号：EP3810262B1

公开(公告)日：2024-07-31

申请号：EP19823410.6

申请日：2019-06-21

IPC分类号： A61N1/36 ,  A61N1/05

CPC分类号： A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/36067 ,  A61N1/36064 ,  A61N1/36178