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38 条记录 (耗时 0.027 秒)

    Cell growth inhibition
    2.
    发明公开
    Cell growth inhibition 审中-公开
    Zellenwachstumshemmung

    公开(公告)号：EP2810653A1

    公开(公告)日：2014-12-10

    申请号：EP14175608.0

    申请日：2000-06-16

    申请人： Zensun (Shanghai) Science and Technology Limited

    发明人： Zhou, Mingdong

    IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/32

    摘要： The disclosure provides a composition for arresting or inhibiting cell growth comprising one or more compounds, in particular antibodies, which prevent or reduce ErbB-2/ErbB-3 heterodimer formation in a cell.

    摘要翻译： 本公开提供了用于阻止或抑制细胞生长的组合物，其包含一种或多种预防或减少细胞中ErbB-2 / ErbB-3异二聚体形成的化合物，特别是抗体。

    NEUKINASE, A DOWNSTREAM PROTEIN OF NEUREGULIN
    6.
    发明公开
    NEUKINASE, A DOWNSTREAM PROTEIN OF NEUREGULIN 有权
    NEUKINASE，NEUREGULIN的DOWNSTREAM蛋白质

    公开(公告)号：EP2059594A1

    公开(公告)日：2009-05-20

    申请号：EP07800751.5

    申请日：2007-08-21

    申请人： Zensun (Shanghai) Science and Technology Limited

    发明人： ZHOU, Mingdong

    IPC分类号： C12N15/11 ,  C12N15/12 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86 ,  C12N9/48 ,  C12N5/16 ,  C12N5/22 ,  C07H21/00 ,  C07K16/16 ,  C07K16/42 ,  C12Q1/68 ,  G01N33/53 ,  A61K31/7088 ,  A61K38/43 ,  A61P9/00

    CPC分类号： C07K16/40 ,  A61K38/45 ,  C12N9/1205 ,  C12Q1/485 ,  G01N33/68 ,  G01N33/6842 ,  G01N2333/4756

    摘要： The present invention relates to neukinase, a downstream protein kinase in the neuregulin signaling pathway. In certain aspects, the present invention provides isolated neukinase-encoding nucleic acids, neukinase polypeptides, oligonucleotides that hybridize to neukinase nucleic acids, and expression vectors containing neukinase-encoding sequences. The present invention further provides isolated host cells, antibodies, transgenic non-human animals, compositions, and kits relating to neukinase. In other aspects, the present invention further provides methods of identifying predisposition to cardiac dysfunction, methods of detecting the presence of neukinase, neukinase nucleic acid, methods of screening for agents which affect neukinase activity, and methods of modulating neukinase activity.

    摘要翻译： 本发明涉及neureinase，神经调节蛋白信号传导途径中的下游蛋白激酶。 在某些方面，本发明提供了分离的编码新生素的核酸，新生素酶多肽，与新生素酶核酸杂交的寡核苷酸和含有编码新生酶的序列的表达载体。 本发明还提供分离的宿主细胞，抗体，转基因非人动物，组合物和与新生酶有关的试剂盒。 在其他方面，本发明进一步提供了鉴定心脏功能障碍的倾向的方法，检测新生酶的存在的方法，新生酸酶核酸，筛选影响新生酶活性的试剂的方法以及调节新生酶活性的方法。

    Neuregulin in the treatment of heart diseases
    7.
    发明公开
    Neuregulin in the treatment of heart diseases 有权
    Neuregulin in der Behandlung von Herzerkrankungen

    公开(公告)号：EP2027869A2

    公开(公告)日：2009-02-25

    申请号：EP08020020.7

    申请日：1999-12-21

    申请人： Zensun (Shanghai) Science and Technology Limited

    发明人： Zhou, Mingdong

    IPC分类号： A61K38/19 ,  A61K48/00 ,  A61P9/00

    CPC分类号： A61K38/1883 ,  C12N5/0657 ,  G01N33/6887 ,  G01N33/74 ,  G01N2333/4756 ,  G01N2800/32 ,  G01N2800/325

    摘要： A method of causing cardiomyocyte growth and/or differentiation, the method comprising exposing a cardiomyocyte to neuregulin (NRG) thereby activating the MAP kinase pathway in the cardiomyocyte and causing growth and/or differentiation of the cardiomyocyte. Use of neuregulin, neuregulin polypeptide, neuregulin derivates, or compounds which mimic the activities of neuregulins in the treatment or management of heart disease and heart failure in a mammal.

    摘要翻译： 一种引起心肌细胞生长和/或分化的方法，所述方法包括将心肌细胞暴露于神经调节蛋白（NRG），由此激活心肌细胞中的MAP激酶途径并引起心肌细胞的生长和/或分化。 神经调节蛋白，神经调节蛋白多肽，神经调节蛋白衍生物或模仿神经调节蛋白活性的化合物在哺乳动物心脏病和心力衰竭的治疗或治疗中的应用。

    SYRINGE PUMP AND DRIVE SYSTEM THEREOF
    9.
    发明公开
    SYRINGE PUMP AND DRIVE SYSTEM THEREOF 有权
    尖沙咀系统ZU IHRER ANSTEUERUNG

    公开(公告)号：EP2783718A1

    公开(公告)日：2014-10-01

    申请号：EP12851161.5

    申请日：2012-11-21

    申请人： Zensun (Shanghai) Science and Technology Limited

    发明人： ZHOU, Mingdong

    IPC分类号： A61M5/00 ,  A61M5/20 ,  A61M5/142

    CPC分类号： A61M5/16886 ,  A61M5/14216 ,  A61M5/1684 ,  A61M2205/3389

    摘要： Disclosed is a drive system of a syringe pump, comprising: an outer sleeve (11) having an inner wall provided with a resistive sheet slot and a conductive sheet slot, both of which slot extending axially; a resistive sheet (12) provided in the resistive sheet slot and a conductive sheet (13) provided in the conductive sheet slot; an injection pushrod (14) slidably provided in the outer sleeve (11), wherein a hermetic seal is maintained between the injection pushrod (14) and the inner wall of the outer sleeve (11), and a cavity having an opening is provided on the injection pushrod (14), with the opening of the cavity being provided at a tail end of the injection pushrod (14); an elastic conductive contact sheet (15) fixedly provided on the injection pushrod (14), with one end of the elastic conductive contact sheet (15) being in contact with the conductive sheet (13) and the other end being in contact with the resistive sheet (12); and a drive device provided in the cavity and driving the injection pushrod (14) to move forth and back. The drive system can ensure the accuracy of administration.

    摘要翻译： 公开了一种注射器泵的驱动系统，包括：外套筒（11），其具有设置有电阻片槽的内壁和导电片狭槽，两个狭槽都轴向延伸; 设置在所述电阻片狭缝中的电阻片（12）和设置在所述导电片狭槽中的导电片（13） 可滑动地设置在所述外套筒（11）中的注射推杆（14），其中在所述注射推杆（14）和所述外套筒（11）的内壁之间保持气密密封，并且具有开口的空腔设置在 注射推杆（14），其中腔的开口设置在注射推杆（14）的尾端; 固定地设置在注射推杆（14）上的弹性导电接触片（15），弹性导电接触片（15）的一端与导电片（13）接触，另一端与电阻 片（12）; 以及设置在所述空腔中并驱动所述注射推杆（14）以前后移动的驱动装置。 驱动系统可以确保管理的准确性。