摘要:
An improved method for separating whole blood into components and collecting a desired blood component. The method allows a desired blood component to be subjected to centrifugal forces within a separator for prolonged periods of time, yielding a cleaner cut and higher yield of the desired blood component. Whole blood is drawn from a source and pumped into a separator, the undesired blood components are removed from the separator at rates so as to build up the desired blood component in the separator. The desired blood component is only removed after a predetermined amount of the desired blood component has built up in the separator. It is preferred that the desired blood component be buffy coat and that the method be used to perform photopheresis treatments. In another aspect, the invention is a method of performing a full photopheresis treatment to treat diseases in a reduced time, preferably less than about 70 minutes, and more preferably less than about 45 minutes.
摘要:
This invention provides a blood processing filter including a flexible container having an inlet and an outlet for blood, and a sheet-like filter media arranged so as to divide the inside of the flexible container into one side and another side. An annular seal part is formed at which an entire circumference that is adjacent to a peripheral portion of the filter media is integrally sealed to the flexible container. The blood processing filter is retained in a curved shape that curves as viewed from a predetermined one direction that is orthogonal to the thickness direction by the rigidity of the seal part.
摘要:
The invention relates to an insert (1) used to receive blood bags (35), said insert being used in a centrifuge in order to separate blood constituents. The insert (1) has a partition (3) dividing a radially inner blood bag region (5) from a radially outer product region, and a cover (9) arranged in a mounting position above the blood bag region (5). The cover (9) is connected to the partition (3) in such a way that it can be rotated on a first point (11) and detached on a second point (13), thereby allowing the blood bag region (5) to be freely accessed by laterally turning the cover (9) away. The insert can be used in the rotor of a centrifuge.
摘要:
The invention relates to a method for extracting cells from blood or from blood products, said method comprising the following steps: (i) a blood bag (35) containing a blood product is placed in a blood bag region (5) of an insert (1); (ii) a tube (36) connected to the blood bag (35) is inserted into a product transport path (36) connecting the blood bag (35) to a product bag (33), a first sensor (25) and a second sensor (85) being positioned along the product transport path (36); (iii) the insert (1) is inserted into the rotor of a centrifuge; (iv) the centrifuge is rotated in order to separate the individual blood constituents; (v) a pre-determined quantity of a blood constituent is transported along the product transport path (36) at a first flow speed; and (vi) the composition of the transported blood constituent is detected by the first sensor (25). The second sensor (85) also detects the composition of the transported blood constituent, according to a signal corresponding to a pre-determined composition of the blood constituent and emitted by the first sensor (25). The transport and rotation are stopped when the second sensor (85) detects the pre-determined composition and emits a corresponding end signal, or when a pre-determined period of time has elapsed.
摘要:
Systems and methods collect leukocyte reduced blood components, including plasma that is free or virtually free of cellular blood species, such as red blood cells, platelets, and leukocytes.
摘要:
An apparatus and method are disclosed for filtering or separating particles. The apparatus has a centrifuge rotor (12) rotatable about an axis of rotation. A fluid chamber (22) rotates with the rotor. A substance is supplied to the inlet (28) of the chamber. A saturated fluidized bed of first particles forms within the fluid chamber and obstructs flow of second particles through the chamber. In an embodiment of the invention, additives substances alter sedimentation velocity of the first particles to modify the filtration characteristics of the saturated fluidized bed. The fluid chamber includes a wall extending between an inlet (28) and outlet (32) to form a fluid chamber interior. The interior converges from a position of maximum cross-sectional area toward the inlet. A groove or a step may be formed on an inner surface of the fluid chamber wall to improve particle separation within the fluid chamber.
摘要:
An apparatus and method are disclosed for filtering or separating particles. A fluid chamber (222) includes a wall extending between an inlet (228) and outlet (232) to form a fluid chamber interior. The interior converges from a position of maximum cross-sectional area (233) toward the inlet. A groove (290) or a step (294) are formed on an inner surface of the fluid chamber wall to improve particle separation within the fluid chamber. The fluid chamber rotates with a centrifuge rotor. A substance is supplied to the inlet of the chamber. A saturated fluidized bed of first particles forms within the fluid chamber and obstructs flow of second particles through the chamber. Additive substances alter sedimentation velocity of the first particles to modify the filtration characteristics of the saturated fluidized bed.