摘要:
The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.
摘要:
The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent such as paclitaxel or rapamycine and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers. In a preferred embodiment, the additive comprises ascorbyl palmitate, polyglycerol-10 oleate, octoxynol-9, ?-isononylphenoxypolyglycidol, tyloxapol, niacinamide, thiamine hydrochloride, nicotinic acid, 2-pyrrolidone-5-carboxylic acid or albumin.
摘要:
A catheter (2) for removing fluid from a patient comprises a tubing (4) having a distal end (6) for insertion into the patient and a proximal end secured to a vacuum control (10) for connection to a vacuum source for effecting removal of the fluid. The vacuum control (10) comprises a first, colour-coded, opaque portion (12) that is gripped by the operator, whereby the degree of suction applied to the catheter tubing (4) from the vacuum source is manually controlled by occlusion of a vent (24) of the first portion (12). A second portion (14) of the vacuum control (10) extends from the first portion (12) and receives the catheter tubing (4). The second portion (14) is substantially transparent and defines an observation chamber to allow the operator to observe the material drawn from the patient.
摘要:
A portable suction device comprising: a gas inlet for receiving pressurized gas from an enclosed source; a gas flow path that extends from the gas inlet to an exhaust; a suction generator that has a suction inlet, the gas flow path extending through the suction generator, such that gas flow through the flow path generates a low pressure at the suction inlet; a collection container with a collection inlet and an outlet that is coupled to the suction inlet; a suction tube that has proximal and distal ends, the proximal end being connected to the collection inlet of the collection container; a valve for controlling gas flow through the flow path, the valve having a stem that is configured to pierce the source with movement of the valve from a closed position.
摘要:
A portable suction device comprising: a gas inlet for receiving pressurized gas from an enclosed source; a gas flow path that extends from the gas inlet to an exhaust; a suction generator that has a suction inlet, the gas flow path extending through the suction generator, such that gas flow through the flow path generates a low pressure at the suction inlet; a collection container with a collection inlet and an outlet that is coupled to the suction inlet; a suction tube that has proximal and distal ends, the proximal end being connected to the collection inlet of the collection container; a valve for controlling gas flow through the flow path, the valve having a stem that is configured to pierce the source with movement of the valve from a closed position.
摘要:
The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, at least one of an oil, a fatty acid, and a lipid, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, a part that has an affinity to the therapeutic agent by charge, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is at least one of a surfactant and a chemical compound. in further embodiments, the chemical compound is water-soluble.
摘要:
The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a. layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive. The invention also relates to a pharmaceutical composition comprising a therapeutic agent, a contrast agent, and an additive, wherein the additive comprises a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent b hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions, wherein the additive is water-soluble, wherein the additive ia at least one of a surfactant and a chemical compound.
摘要:
Described here are devices, systems, and methods for positioning a suction catheter in the airway of a patient. The systems may comprise a suction catheter, a delivery device, and/or a stylet. The delivery device may comprise an elongate shaft, an atraumatic distal end, an elongate passageway, and a retention element configured to releasably couple to an endotracheal tube. The suction catheter may be positioned in the elongate passageway, and the delivery device may help advance the suction catheter into the airway of a patient. In some variations, the delivery device may comprise elements configured to release the suction catheter in the airway after positioning.
摘要:
The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.
摘要:
The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, at least one of an oil, a fatty acid, and a lipid, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, a part that has an affinity to the therapeutic agent by charge, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is at least one of a surfactant and a chemical compound. in further embodiments, the chemical compound is water-soluble.