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    OPTOGENETIC THERAPIES FOR MOVEMENT DISORDERS
    2.
    发明公开
    OPTOGENETIC THERAPIES FOR MOVEMENT DISORDERS 审中-公开
    OPTOGENETISCHE THERAPIENFÜRBEWEGUNGSSTÖRUNGEN

    公开(公告)号：EP3154632A1

    公开(公告)日：2017-04-19

    申请号：EP15807014.4

    申请日：2015-06-11

    申请人： Circuit Therapeutics, Inc.

    发明人： KAPLITT, Michael ,  ANDERSEN, Dan

    IPC分类号： A61N5/06 ,  A61M37/00

    CPC分类号： A61N5/062 ,  A61B5/00 ,  A61B2017/00057 ,  A61K48/00 ,  A61N5/0622 ,  A61N2005/065 ,  C12N2750/14143

    摘要： One embodiment is directed to a method for controllably managing motor function in the central nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising: providing a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure, a light source configured to provide light to the light delivery element, and a controller operatively coupled to light source, wherein the targeted tissue structure is a portion of the basal ganglia of the patient; and automatically operating the controller to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation.

    摘要翻译： 一个实施方案涉及一种用于可控地管理具有已经被遗传修饰以具有光敏蛋白质的靶组织结构的患者的中枢神经系统中的运动功能的方法，包括：提供配光以将辐射引导至少 目标组织结构的一部分，被配置为向光输送元件提供光的光源和可操作地耦合到光源的控制器，其中所述目标组织结构是患者的基底神经节的一部分; 并且自动操作所述控制器以用辐射照亮所述目标组织结构，使得包含所述靶组织结构的细胞的膜电位至少部分地由于所述光敏蛋白质暴露于所述辐射而被调节。

    LASER BEAM IRRADIATION DEVICE
    3.
    发明授权
    LASER BEAM IRRADIATION DEVICE 有权
    激光照射装置

    公开(公告)号：EP1433499B1

    公开(公告)日：2010-11-03

    申请号：EP02765500.0

    申请日：2002-09-11

    申请人： Yaman Ltd.

    发明人： YAMAZAKI, Iwao c/o YAMAN Ltd. ,  YAMAZAKI, Kimiyo c/o YAMAN Ltd.

    IPC分类号： A61N5/06

    CPC分类号： A61N5/0616 ,  A61B18/203 ,  A61B2018/00452 ,  A61N2005/0644 ,  A61N2005/065 ,  A61N2005/0651 ,  A61N2005/067

    摘要： A laser beam irradiation device which permits general users to operate it safely by providing a laser beam emitting control circuit with very strict safety measures. For a safe operation, a head unit (H) is projectingly provided on the front surface, and a pressing switch (S4) is attached to the side surface. The head unit (H) comprises a spherical lens (31) fittingly inserted into an opening at the center thereof, and a forward cylinder (32) integrally attached to the outer periphery of the spherical lens (31) so as to come into contact with the skin at the tip end thereof. A cylindrical electrode (33) is buried in the tip end of the forward cylinder (32) so as to project forward at the tip end thereof beyond the opening end surface. A heat sink (34) is provided in the rear of the spherical lens (31), and a semiconductor laser diode (35) is fittingly inserted into the inner portion of a through hole made in the axis of the heat sink. A fan (36) for cooling the heat sink (34) is installed behind it.

    INTEGRATED OPTICAL NEURAL PROBE
    6.
    发明公开
    INTEGRATED OPTICAL NEURAL PROBE 审中-公开
    INTEGRIERTE OPTISCHE NEURALE SONDE

    公开(公告)号：EP2736407A2

    公开(公告)日：2014-06-04

    申请号：EP12818177.3

    申请日：2012-07-24

    申请人： Diagnostic Biochips, LLC

    发明人： JAMIESON, Brian ,  MATEO, Jennette

    IPC分类号： A61B5/04 ,  A61B6/00

    CPC分类号： A61B5/6868 ,  A61B5/0084 ,  A61B5/04001 ,  A61B5/6848 ,  A61B2018/2266 ,  A61B2018/2272 ,  A61B2562/046 ,  A61N5/0622 ,  A61N2005/0612 ,  A61N2005/065

    摘要： In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.

    摘要翻译： 在某些实施例中，神经探针包括基底，其包括用于穿透神经组织的细长柄，每个包括近端和远端; 至少一个与神经探针成一体的光源，用于照射神经组织; 和位于细长柄的远端附近的微电极，用于监测神经元的活动。 在某些实施方案中，监测神经元活性的方法包括将神经探针植入测试对象中，使得细长柄突出到测试对象的神经组织中; 用所述至少一个光源照亮所述神经组织; 并测量响应照射神经组织的神经元活动。 在某些实施例中，装置包括半导体芯片; 至少一个与半导体芯片成一体的光源; 以及与所述半导体芯片成一体的传感器元件，用于响应于从所述至少一个光源发射的光来收集数据。

    APPARATUS FOR APPLYING PULSED CHARGE TO LIVING MATTER
    7.
    发明公开
    APPARATUS FOR APPLYING PULSED CHARGE TO LIVING MATTER 审中-公开
    DEVICE FOR施加脉冲充电对生命物质

    公开(公告)号：EP1874395A2

    公开(公告)日：2008-01-09

    申请号：EP05790942.6

    申请日：2005-08-16

    申请人： James, Robert G.

    发明人： James, Robert G.

    IPC分类号： A61N1/00 ,  A61F2/00

    CPC分类号： A61N5/0613 ,  A61N1/40 ,  A61N2/002 ,  A61N2/02 ,  A61N2005/065 ,  A61N2005/0655 ,  H01J61/12 ,  H01J65/046

    摘要： Apparatus for inducing electrically charged alignment changes in biological tissue includes a generally flat translucent cavity containing a volume of gas that includes water vapor, carbon dioxide and other similarly common molecules that is charged along one surface by a sequence of pulses of electrical charge each of a potential sufficient to excite the common molecules to a higher state. The opposite side of the cavity is then conformed for intimate contact with the skin of a person, thus communicating the right hand spin electromagnetic pulses associated with each excitation level change into the tissue. A pulsed coil is then provided in an alignment generally parallel to the plane of the cavity to polarize the clockwise electromagnetic emissions associated with the changes in the excitation states.