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公开(公告)号：EP4426682A1
公开(公告)日：2024-09-11
申请号：EP22889255.0
申请日：2022-11-01
发明人： DING, Xiao , PENG, Jingjing , REN, Feng , DING, Xiaoyu , ZAGRIBELNYY, Bogdan , IVANENKOV, Yan A.
IPC分类号： C07D239/02 , C07D401/02 , C07D403/02 , A61K31/435 , A61K31/495 , A61P31/14
CPC分类号： A61P31/14 , C07D417/12 , C07D413/12 , C07D239/26 , C07D405/12 , C07D213/61 , C07D213/85 , C07D213/64 , C07D401/12 , C07D261/08 , C07D405/14 , C07D403/12 , C07D493/08 , C07B59/002 , C07D417/14 , C07D213/56 , C07B2200/0520130101
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公开(公告)号：EP4423084A1
公开(公告)日：2024-09-04
申请号：EP22886216.5
申请日：2022-10-25
发明人： ISAAC, Methvin
IPC分类号： C07D457/12 , A61K31/48
CPC分类号： C07D457/02 , C07B59/002 , A61P25/00 , A61P25/22 , A61P25/30 , A61P25/24 , C07B2200/0520130101
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公开(公告)号：EP4249456B1
公开(公告)日：2024-09-04
申请号：EP23167668.5
申请日：2020-01-30
CPC分类号： A61P35/00 , C07B2200/0520130101 , C07B59/008 , A61K51/0497 , A61K51/0406
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4.发明公开
公开(公告)号：EP4406930A1
公开(公告)日：2024-07-31
申请号：EP23198240.6
申请日：2023-09-19
申请人： JEOL Ltd. , Nihon University
IPC分类号： C07B59/00 , C07D209/42 , G01N30/72 , G01N33/68
CPC分类号： C07B59/002 , C07B2200/0520130101 , C07D209/42
摘要： The present invention is intended to provide a novel compound that can be used to detect or quantify a melanin-relating metabolite. The present invention provides a stable isotope-labeled indole carboxylic acid compound represented by Formula (I):
[in Formula (I), X1 to X8 are each independently C or 13C; Y is N or 15N; M is H, Na, K, Li, CH3, or C2H5; R1 is H or D; R2 is H, CH3, 13CH3, C2H5, or 13C2H5; R3 is H, CH3, 13CH3, C2H5, or 13C2H5; R4 is H or D; and R5 is H or D].-
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公开(公告)号：EP4384507A1
公开(公告)日：2024-06-19
申请号：EP22855421.8
申请日：2022-08-09
发明人： SHU, Chutian , TIAN, Jin
IPC分类号： C07D263/22 , C07D413/12 , A61K31/421 , A61K31/422 , A61P3/10 , A61P3/00 , A61P9/00
CPC分类号： A61P3/00 , A61P3/10 , A61P9/00 , C07D413/12 , C07B59/002 , C07B2200/0520130101
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7.发明公开
公开(公告)号：EP4355724A1
公开(公告)日：2024-04-24
申请号：EP22734296.1
申请日：2022-06-16
发明人： GLÖGGLER, Stefan , KORCHAK, Sergey , JATAP, Anil P. , SAUL, Philip , MOLL, Denis
IPC分类号： C07C69/68 , C07C67/307 , C07C67/31 , C07C271/22 , C07C201/12 , C07C205/34 , C07B59/00
CPC分类号： C07C271/22 , C07C67/307 , C07C67/31 , C07C69/68 , C07B2200/0520130101 , C07B59/001 , C07C201/12
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公开(公告)号：EP4442093A1
公开(公告)日：2024-10-09
申请号：EP22823452.2
申请日：2022-11-30
申请人： Merck Patent GmbH
CPC分类号： H10K85/615 , H10K85/654 , H10K50/18 , C07B2200/0520130101 , C07D251/24 , C07D239/26 , Y02E10/549
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公开(公告)号：EP4438608A2
公开(公告)日：2024-10-02
申请号：EP24193023.9
申请日：2018-08-03
申请人： Osaka University
发明人： SHIRAKAMI, Yoshifumi , IKEDA, Hayato , KANAI, Yasukazu , SHIMOSEGAWA, Eku , HATAZAWA, Jun , WATABE, Tadashi , KANEDA, Kazuko
IPC分类号： C07F5/02
CPC分类号： C07F5/025 , C07B2200/0520130101 , C07F13/005 , C07B59/004
摘要： The present invention aims to produce a radiolabeled aryl compound by a method that enables an easy labelling with a high radiochemical yield in a short time, and that enables formulation immediately after the labelling.
The present invention relates to a method of producing the radiolabeled aryl compound (I), which comprises reacting the aryl boronic acid compound (II) with a radionuclide selected from 123I, 124I, 125I and 131I, in the presence of an oxidizing agent selected from N-bromosuccinimide and N-chlorosuccinimide, in water.
Ar-X (I)
Ar-Y (II)
wherein each symbol is as defined in the description.-
公开(公告)号：EP4423065A1
公开(公告)日：2024-09-04
申请号：EP22809746.5
申请日：2022-10-26
申请人： Merck Patent GmbH
IPC分类号： C07D209/86 , C07C211/54 , C07C211/60 , C07D209/94 , C07D307/91 , C07D333/76 , H10K85/00 , H10K50/00
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