IMPROVED METHOD FOR PRODUCING NITROISOUREA DERIVATIVE
    2.
    发明公开
    IMPROVED METHOD FOR PRODUCING NITROISOUREA DERIVATIVE 审中-公开
    VERBESSERTES VERFAHREN ZUR HERSTELLUNG EINES NITROISOHARNSTOFFDERIVATS

    公开(公告)号:EP1985610A1

    公开(公告)日:2008-10-29

    申请号:EP07706313.9

    申请日:2007-02-07

    摘要: Disclosed is an improved process for producing nitroisourea derivatives which is necessary for producing nitroguanidine derivatives having an insecticidal activity. Specifically disclosed is a process for producing nitroisourea derivatives represented by the following general formula (3), which is characterized in that nitroisourea derivatives represented by the following general formula (1) and amines represented by the following general formula (2) or a salt thereof are reacted in the presence of a catalytic amount of a hydrogen carbonate,

    摘要翻译: 公开了生产具有杀虫活性的硝基胍衍生物所必需的硝基异脲衍生物的改进方法。 具体公开了下述通式(3)表示的硝基异脲衍生物的制造方法,其特征在于,将下述通式(1)表示的硝基异
    脲衍生物或下述通式(2)表示的胺或其盐 在催化量的碳酸氢盐存在下反应,

    BIFUNCTIONAL CONJUGATE COMPOSITIONS AND ASSOCIATED METHODS
    9.
    发明公开
    BIFUNCTIONAL CONJUGATE COMPOSITIONS AND ASSOCIATED METHODS 审中-公开
    BIFUNKTIONELLE KONJUGATZUSAMMENSETZUNGEN UND VERFAHRENDAFÜR

    公开(公告)号:EP2585096A2

    公开(公告)日:2013-05-01

    申请号:EP11798980.6

    申请日:2011-06-24

    IPC分类号: A61K38/16

    摘要: Bifunctional conjugate compositions are provided comprising a Signal- 1 moiety bound to a first polymer carrier, wherein the combined size of the Signal- 1 moiety and the first polymer carrier is about 1 nanometer to about 500 nanometers; and a Signal-2 moiety bound to a second polymer carrier, wherein the combined size of the Signal-2 moiety and the second polymer carrier is about 1 nanometer to about 500 nanometers. In some embodiments, the Signal- 1 moiety and the Signal-2 moiety are bound to the same polymer carrier. Associated methods are also provided.

    摘要翻译: 公开了包含N-肟键的缀合物。 在一个实施方案中,合适的缀合物由下式(I)表示:其中R'衍生自包含至少一个反应性酰胺基的化合物,R“衍生自包含至少一个反应性氨基氧基的化合物,X 是H,CnH(n + 2)或其他原子。 还提供了附加方法。