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    Conversion of a multihydroxylated aliphatic hydrocarbon or ester thereof to a chlorohydrin
    2.
    发明公开
    Conversion of a multihydroxylated aliphatic hydrocarbon or ester thereof to a chlorohydrin 有权
    多羟基脂族烃或其酯转化成氯代醇

    公开(公告)号：EP2181979A1

    公开(公告)日：2010-05-05

    申请号：EP09177404.2

    申请日：2005-07-18

    申请人： DOW GLOBAL TECHNOLOGIES INC.

    发明人： Schreck, David J. ,  Kruper, William, J. Jr. ,  Varjian, Richard D. ,  Jones, Mark E. ,  Campbell, Robert M. ,  Kearns, Kenneth Jr. ,  Hook, Bruce D. ,  Briggs, John R. ,  Hippler, Jeffrey G.

    IPC分类号： C07C29/62 ,  C07D303/08 ,  C07D301/24

    CPC分类号： C07D301/24 ,  C07C29/62 ,  C07C29/82 ,  C07C31/36 ,  C07C31/42

    摘要： A process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

    摘要翻译： 通过使多羟基化脂族烃或其酯与起始材料与超大气压氯化氢分压源接触足够的时间并在足够的温度下将多羟基化脂族烃或其酯转化为氯代醇的方法，以及 其中这种收缩步骤是在基本上不除去水的情况下进行的，以产生所需的氯代醇产物; 其中可以高收率地制备所需的一种或多种产物而基本不会形成不希望的过氯化副产物。 另外，本发明的某些催化剂可以在超大气压，大气压和低于大气压条件下用于本发明方法中，并具有改进的结果。

    FLUORINE-CONTAINING ADAMANTANE DERIVATIVE, FLUORINE-CONTAINING ADAMANTANE DERIVATIVE HAVING POLYMERIZABLE GROUP, RESIN COMPOSITION CONTAINING THE SAME, AND ANTIREFLECTION FILM
    4.
    发明公开
    FLUORINE-CONTAINING ADAMANTANE DERIVATIVE, FLUORINE-CONTAINING ADAMANTANE DERIVATIVE HAVING POLYMERIZABLE GROUP, RESIN COMPOSITION CONTAINING THE SAME, AND ANTIREFLECTION FILM 审中-公开
    FLUOR含金刚烷，福陆含金刚烷聚合的基团，树脂组合物这包含和防反射膜

    公开(公告)号：EP2014639A1

    公开(公告)日：2009-01-14

    申请号：EP07742063.6

    申请日：2007-04-20

    申请人： Idemitsu Kosan Co., Ltd.

    发明人： OKADA, Yasunari ,  YAMANE, Hideki ,  ITO, Hajime ,  MATSUMOTO, Nobuaki

    IPC分类号： C07C69/653 ,  C07C31/44 ,  C07C67/14 ,  C07D301/24 ,  C07D303/30 ,  C08L101/00 ,  G02B1/04 ,  G02B1/11

    CPC分类号： C07C31/44 ,  C07C69/653 ,  C07C2603/74 ,  C07D301/24 ,  C07D305/06 ,  C08F220/24 ,  C08F222/1006

    摘要： To provide a polymerizable group-containing and fluorine-containing adamantane derivative capable of affording a cured product having good heat resistance, good mechanical properties such as mar resistance and a low refractive index, a resin composition containing such a polymerizable group-containing adamantane derivative, and a fluorine-containing adamantane derivative which is useful as a reaction intermediate used for the production of the polymerizable group-containing and fluorine-containing adamantane derivative.
    Specifically provided are a fluorine-containing adamantane derivative represented by the general formula (I) below, a polymerizable group-containing and fluorine-containing adamantane derivative represented by the general formula (II) below, and a resin composition containing such a polymerizable group-containing and fluorine-containing adamantane derivative. In the formula, R 1 and R 2 are each a hydrogen atom, for example, n is an integer of 0 or more, X 1 is a polymerizable group represented by the formula (III-a), for example, Y is a hydrogen atom, for example, s and t are each an integer of 1 to 15, and u is an integer of 0 to 14, with the proviso that s + t + u = 16.

    摘要翻译： 提供和含氟金刚烷衍生物能够得到具有良好耐热性的固化物的含有聚合性基团的，良好的机械性能：如耐擦伤性和低折射率，含寻求含聚合性基团的金刚烷衍生物的树脂组合物， 和含氟金刚烷衍生物所有作为中间体的反应用于生产含聚合性基团的含氟金刚烷衍生物的，这是有用。 下面具体地提供了由通式（I）表示的含氟金刚烷衍生物，含有聚合性基团和由下面的通式（II）表示的含氟金刚烷衍生物，和树脂组合物包含寻求可聚合基团 - 含有氟和含金刚烷衍生物。 氢在该式中，R 1和R 2各自为氢原子，对于实施例中，n是0以上的整数，X 1是由式（III-A）表示的聚合性基团，例如，Y是 核，例如，s和t各自为1至15的整数，u是0〜14的整数，前提条件做S + T + U = 16

    OPTICALLY ACTIVE HALOHYDRIN DERIVATIVE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE EPOXY ALCOHOL DERIVATIVE FROM THE SAME
    9.
    发明公开
    OPTICALLY ACTIVE HALOHYDRIN DERIVATIVE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE EPOXY ALCOHOL DERIVATIVE FROM THE SAME 有权
    光有源卤代和工艺及其生产光学活性EPOXYALKOHOLDERIVATS

    公开(公告)号：EP1647551A1

    公开(公告)日：2006-04-19

    申请号：EP04747351.7

    申请日：2004-07-05

    申请人： KANEKA CORPORATION

    发明人： OKURO, Kazumi ,  TANAKA, Tatsuyoshi ,  MITSUDA, Masaru ,  INOUE, Kenji

    IPC分类号： C07D301/24 ,  C07D303/14 ,  C07D249/08 ,  C07D309/12 ,  C07D405/06 ,  C07C33/46 ,  C07C29/10 ,  C07C43/178 ,  C07C41/26 ,  C07C69/28 ,  C07C67/29 ,  C07F7/08 ,  C07B53/00

    CPC分类号： C07C67/29 ,  C07B2200/07 ,  C07C29/10 ,  C07D301/24 ,  C07C33/46

    摘要： The present invention provides an industrially safe, easily operable process for producing an optically active epoxy alcohol derivative useful as an intermediate for pharmaceuticals from inexpensively available materials, and also provides a novel halohydrin derivative serving as an important intermediate for the epoxyalcohol derivative. Furthermore, the present invention provides a process for producing an intermediate for a triazole antifungal agent by allowing a halohydrin to react with a triazole sulfonamide, the process including a small number of steps. A process for producing an optically active epoxy alcohol derivative includes allowing an optically active α-substituted propionate derivative to react with a haloacetic acid derivative in the presence of a base to prepare an optically active haloketone derivative, allowing the resulting haloketone derivative to react with an aryl metal compound to stereoselectively prepare a halohydrin derivative, eliminating a substituent for the hydroxy group of the halohydrin derivative, and performing epoxidation with a base. Furthermore, a process for producing an intermediate for a triazole antifungal agent includes allowing a halohydrin derivative to react with a triazole sulfonamide, the process including a small number of steps.

    摘要翻译： 本发明提供工业上上安全，易于操作处理，用于光学活性环氧醇衍生物可用作在中间从廉价地获得的材料制备药物，并且因此提供了一种新型的卤代醇在重要中间体衍生物用作用于环氧醇衍生物。 进一步地，本发明提供了用于通过允许卤代醇与三唑磺酰胺，该方法包括少量步骤反应在中间为三唑类抗真菌剂的制造方法。 一种用于在光学活性环氧醇衍生物的制造方法包括：允许向旋光±取代丙酸酯衍生物在碱的存在下，卤代乙酸衍生物反应来制备光学活性的卤代酮衍生物，使所得卤代酮衍生物与在反应 芳金属化合物立体选择性地制备卤代醇衍生物，消除了对卤代醇衍生物的羟基的取代基，并用碱进行环氧化作用。 进一步，在中间制造用于三唑类抗真菌剂的方法包括：允许卤代醇衍生物与三唑磺酰胺，该方法包括少量步骤反应。

    PROCESS FOR PREPARING OPTICALLY ACTIVE EPOXIDES
    10.
    发明授权
    PROCESS FOR PREPARING OPTICALLY ACTIVE EPOXIDES 有权
    工艺生产光学-ACTIVE环氧化物

    公开(公告)号：EP1318990B1

    公开(公告)日：2004-03-24

    申请号：EP01967496.9

    申请日：2001-09-18

    申请人： Phoenix Chemicals Limited

    发明人： JUSTICE, David, Edward

    IPC分类号： C07D303/36 ,  C07D301/24

    CPC分类号： C07D301/24 ,  C07D303/36

    摘要： The invention concerns a process for the production of optically active epoxides useful as pharmaceutical intermediates, particularly in the field of HIV protease inhibitors. The optically active epoxides are produced in commercially acceptable yields from an optically active alcohols by a Mitsunobu reaction and a cyclisation step, preferably comprising an intermediate recrystallisation step. The stereochemistry of the alcohol is inverted during the Mitsunobu reaction to produce the desired epoxide.