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1.发明授权CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives 有权CNS-有效和稠合杂环基取代的双环烷烃衍生物azabicyklische
公开(公告)号：EP2431368B1
公开(公告)日：2014-08-27
申请号：EP11185419.6
申请日：2007-05-15
申请人： AbbVie Bahamas Ltd.
IPC分类号： C07D451/08 , C07D451/14 , C07D519/00 , A61K31/4375 , A61P25/00
CPC分类号： C07D451/08 , C07D451/14 , C07D519/00
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2.发明公开Neue quartäre 6,11-Dihydro-dibenzo-(b,e)-thiepin-11-N-alkyl-norscopinether und Verfahren zu deren Herstellung 失效新季6,11-二氢 - 二苯并（B，E）硫_-11- N-烷基norscopinether和它们的制备方法。
公开(公告)号：EP0090195A1
公开(公告)日：1983-10-05
申请号：EP83102109.2
申请日：1983-03-04
IPC分类号： C07D451/06 , A61K31/46
CPC分类号： C07D451/06 , C07D451/08
摘要： Quartäre 6,11-Dihydro-dibenzo-[b,e],thiepin-11-N-al- kylnorscopinether der allgemeinen Formel
worin R einen geradkettigen oder verzweigten Alkylrest mit 1-10 Kohlenstoffatomen und X (-) ein pharmakologisch unbedenkliches Anion wie etwa ein Halogenatom oder den Rest einer organischen Sulfonsäure bedeutet. Verfahren zu deren Herstellung, sowie die tertiären Zwischenprodukte und ihre Verwendung als Spasmolytika oder Bronchospa smolytika.摘要翻译： 季-6,11-二氢二苯并[b，E]硫_-11--N-alkylnorscopinether通式
其中R是具有1-10个碳原子和X <（ - ）>的直链或支链烷基的药理学可接受的 意味着阴离子，如卤原子或有机磺酸残基。 它们的制备方法，以及作为第三中间体和它们作为解痉药或Bronchospa smolytika使用。 -
3.发明授权Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives 有权CNS活化稠双环和杂环取代的烷烃衍生物azabicyklische
公开(公告)号：EP2018380B1
公开(公告)日：2011-10-19
申请号：EP07797473.1
申请日：2007-05-15
申请人： ABBOTT LABORATORIES
IPC分类号： C07D451/08 , C07D451/14 , C07D519/00 , A61K31/4375 , A61P25/00
CPC分类号： C07D451/08 , C07D451/14 , C07D519/00
摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar2 is a bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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4.发明公开
公开(公告)号：EP1919476A2
公开(公告)日：2008-05-14
申请号：EP06789971.6
申请日：2006-08-24
IPC分类号： A61K31/439 , C07D451/08 , A61P25/30
CPC分类号： A61K31/46 , A61K51/0455 , C07D451/08
摘要： Disclosed are benztropine analogs having the formula (I) in which Ar is a C6-C20 monocyclic aryl group or a C10-C20 bicyclic aryl group or a heteroaryl, heterocyclic, or arylheterocyclic group having 2 to 12 carbon atoms and one or more heteroatoms selected from the group consisting of N, O, S, P, and any combination thereof; m = 1 to 5; n = 1 to 3; and R1 to R4 are as described in the specification; or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical compositions and use thereof, e.g., in treating mental disorders.
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5.发明公开CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives 有权CNS-wirksame kondensierte bicyclo und heterolislis替代物azabicyklische Alkanderivate
公开(公告)号：EP2431368A1
公开(公告)日：2012-03-21
申请号：EP11185419.6
申请日：2007-05-15
申请人： Abbott Laboratories
IPC分类号： C07D451/08 , C07D451/14 , C07D519/00 , A61K31/4375 , A61P25/00
CPC分类号： C07D451/08 , C07D451/14 , C07D519/00
摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及稠合的双环杂环取代的氮杂双环烷烃衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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6.发明公开PIPERIDINE AND PIPERAZINE DERIVATIVES AS INHIBITORS OF THE ABETA FIBRIL FORMATION 审中-公开哌啶和哌嗪衍生物AS ABETAFIBRILLENBILDUNG抑制剂的
公开(公告)号：EP1150971A1
公开(公告)日：2001-11-07
申请号：EP00906300.9
申请日：2000-02-08
IPC分类号： C07D401/06 , A61K31/435 , A61P25/28 , C07D401/14 , C07D451/08 , C07D221/08 , C07D457/02
CPC分类号： C07D401/06 , C07D221/08 , C07D401/14 , C07D451/08 , C07D457/02
摘要： A compound of formula (I) wherein X is (II) or (III) wherein R' is a group (a), R is a group (e) or (f) wherein n is 0 to 3. In particular the agents of the invention inhibit the formation of β-amyloid (Aβ) peptide into neurotoxic fibrils, thereby acting to prevent or slow down the accumulation of amyloid protein deposits in the brain.
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7.发明公开CNS ACTIVE FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES 有权CNS活化稠双环和杂环取代的烷烃衍生物azabicyklische
公开(公告)号：EP2018380A2
公开(公告)日：2009-01-28
申请号：EP07797473.1
申请日：2007-05-15
申请人： ABBOTT LABORATORIES
IPC分类号： C07D451/08 , C07D451/14 , C07D519/00 , A61K31/4375 , A61P25/00
CPC分类号： C07D451/08 , C07D451/14 , C07D519/00
摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar2 is a bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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8.发明授权Neue quartäre 6,11-Dihydro-dibenzo-(b,e)-thiepin-11-N-alkyl-norscopinether und Verfahren zu deren Herstellung 失效季戊四醇六（D，E）-THIEPIN-11-N-ALKYL-NORSCOPIN ETHERS及其制备方法
公开(公告)号：EP0090195B1
公开(公告)日：1985-11-21
申请号：EP83102109.2
申请日：1983-03-04
IPC分类号： C07D451/06 , A61K31/46
CPC分类号： C07D451/06 , C07D451/08
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9.发明授权4',4''-SUBSTITUTED 3ALPHA-(DIPHENYLMETHOXY)TROPANE ANALOGS FOR THE TREATMENT OF ADHD 有权4“ 4' ” - 取代3ALPHA-（二苯基甲氧基）莨菪烷类似物对治疗ADHD
公开(公告)号：EP1624845B1
公开(公告)日：2011-03-09
申请号：EP04701273.7
申请日：2004-01-09
申请人： P2D Inc.
发明人： ZEMLAN, Frank, P.
CPC分类号： C07D451/08 , A61K31/46
摘要： The present invention describes a method for the treatment of attention deficit hyperactivity disorder (ADHD), conduct disorder, alcohol addiction, tobacco addiction, nicotine addiction, parkinsonim including Parkinson's disease, female and male orgasmic disorders, female and male sexual arousal disorders, hypoactive sexual desire disorder, and disorders characterized by anxiety and/or depression. In this method, a therapeutically effective, nontoxid dose of a 4',4''-substituted 3α-(diphenylmethoxy)tropane analog or a pharmaceutically acceptable salt thereof is administered to the patient in need of such treatment.
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10.发明公开4',4''-SUBSTITUTED 3ALPHA-(DIPHENYLMETHOXY)TROPANE ANALOGS FOR TREATMENT OF MENTAL DISORDERS 有权4“ 4' ” - 取代3ALPHA-（二苯基甲氧基）莨菪烷类似物对治疗ADHD
公开(公告)号：EP1624845A2
公开(公告)日：2006-02-15
申请号：EP04701273.7
申请日：2004-01-09
发明人： ZEMLAN, Frank, P.
IPC分类号： A61K6/00
CPC分类号： C07D451/08 , A61K31/46
摘要： The present invention describes a method for the treatment of attention deficit hyperactivity disorder (ADHD), conduct disorder, alcohol addiction, tobacco addiction, nicotine addiction, parkinsonim including Parkinson's disease, female and male orgasmic disorders, female and male sexual arousal disorders, hypoactive sexual desire disorder, and disorders characterized by anxiety and/or depression. In this method, a therapeutically effective, nontoxid dose of a 4',4''-substituted 3α-(diphenylmethoxy)tropane analog or a pharmaceutically acceptable salt thereof is administered to the patient in need of such treatment.
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