-
1.发明公开CNS ACTIVE FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES 有权CNS活化稠双环和杂环取代的烷烃衍生物azabicyklische
公开(公告)号：EP2018380A2
公开(公告)日：2009-01-28
申请号：EP07797473.1
申请日：2007-05-15
申请人： ABBOTT LABORATORIES
IPC分类号： C07D451/08 , C07D451/14 , C07D519/00 , A61K31/4375 , A61P25/00
CPC分类号： C07D451/08 , C07D451/14 , C07D519/00
摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar2 is a bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
-
2.发明授权CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives 有权CNS-有效和稠合杂环基取代的双环烷烃衍生物azabicyklische
公开(公告)号：EP2431368B1
公开(公告)日：2014-08-27
申请号：EP11185419.6
申请日：2007-05-15
申请人： AbbVie Bahamas Ltd.
IPC分类号： C07D451/08 , C07D451/14 , C07D519/00 , A61K31/4375 , A61P25/00
CPC分类号： C07D451/08 , C07D451/14 , C07D519/00
-
3.发明授权Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives 有权CNS活化稠双环和杂环取代的烷烃衍生物azabicyklische
公开(公告)号：EP2018380B1
公开(公告)日：2011-10-19
申请号：EP07797473.1
申请日：2007-05-15
申请人： ABBOTT LABORATORIES
IPC分类号： C07D451/08 , C07D451/14 , C07D519/00 , A61K31/4375 , A61P25/00
CPC分类号： C07D451/08 , C07D451/14 , C07D519/00
摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar2 is a bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
-
4.发明公开
公开(公告)号：EP1919476A2
公开(公告)日：2008-05-14
申请号：EP06789971.6
申请日：2006-08-24
IPC分类号： A61K31/439 , C07D451/08 , A61P25/30
CPC分类号： A61K31/46 , A61K51/0455 , C07D451/08
摘要： Disclosed are benztropine analogs having the formula (I) in which Ar is a C6-C20 monocyclic aryl group or a C10-C20 bicyclic aryl group or a heteroaryl, heterocyclic, or arylheterocyclic group having 2 to 12 carbon atoms and one or more heteroatoms selected from the group consisting of N, O, S, P, and any combination thereof; m = 1 to 5; n = 1 to 3; and R1 to R4 are as described in the specification; or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical compositions and use thereof, e.g., in treating mental disorders.
-
5.发明授权8-Azabicyclo[3.2.1]octylalkylthiazolidinones, a process for their preparation and their use as medicaments 失效8-氮杂二环[3.2.1] octylalkylthiazolidinones，它们的制备以及它们作为药物使用的处理
公开(公告)号：EP0483633B1
公开(公告)日：1997-04-09
申请号：EP91117906.7
申请日：1991-10-21
发明人： Hrib, Nicholas J. , Jurcak, John G.
IPC分类号： C07D451/08 , A61K31/46
CPC分类号： C07D451/08
-
6.发明公开8-Azabicyclo[3.2.1]octylalkylthiazolidinones, a process for their preparation and their use as medicaments 失效8-氮杂二环[3.2.1] octylalkylthiazolidinones，它们的制备以及它们作为药物的用途。
公开(公告)号：EP0483633A1
公开(公告)日：1992-05-06
申请号：EP91117906.7
申请日：1991-10-21
发明人： Hrib, Nicholas J. , Jurcak, John G.
IPC分类号： C07D451/08 , A61K31/46
CPC分类号： C07D451/08
摘要： The present invention relates to novel 8-azabicyclo[3.2.1]octylalkylthiazolidinones of formula
wherein R¹ and R² are independently hydrogen or alkyl; R³ and R⁴ are independently hydrogen or alkyl; X and Y are independently hydrogen, alkyl, alkoxy, halogen or trifluoromethyl; m is 2, 3 or 4, which are useful for treating psychoses.摘要翻译： 本发明涉及新的8-氮杂双环[3.2.1]式octylalkylthiazolidinones
worin - [R <1>和R <2>是unabhängig氢或烷基; [R <3>和R <4>是unabhängig氢或烷基; X和Y独立地是氢，烷基，烷氧基，卤素或三氟甲基; m为2，3或4，可用于治疗精神病有用的。 -
公开(公告)号：EP3880674A1
公开(公告)日：2021-09-22
申请号：EP21702880.2
申请日：2021-01-22
发明人： PANT, Kritee , ROSCHKE, Felix
IPC分类号： C07D451/08 , A61K51/04
-
8.发明公开CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives 有权CNS-wirksame kondensierte bicyclo und heterolislis替代物azabicyklische Alkanderivate
公开(公告)号：EP2431368A1
公开(公告)日：2012-03-21
申请号：EP11185419.6
申请日：2007-05-15
申请人： Abbott Laboratories
IPC分类号： C07D451/08 , C07D451/14 , C07D519/00 , A61K31/4375 , A61P25/00
CPC分类号： C07D451/08 , C07D451/14 , C07D519/00
摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及稠合的双环杂环取代的氮杂双环烷烃衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
-
9.发明公开Heteroaromatic bicyclic derivatives useful as anticancer agents 审中-公开Heteroaromatische Bicyclen als反Krebs Mittel
公开(公告)号：EP1396489A1
公开(公告)日：2004-03-10
申请号：EP03024331.5
申请日：1999-12-24
申请人： Pfizer Products Inc.
IPC分类号： C07D239/94 , C07D453/02 , C07D451/02 , C07D451/08 , A61K31/505 , A61P35/00
CPC分类号： C07D401/10 , A61K45/06 , C07D239/94 , C07D403/10 , C07D405/12 , C07D451/02 , C07D453/02
摘要： The invention relates to compounds of the formula 1
and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R 1 , R 3 and R 4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1 . The invention also relates to methods of preparing the compounds of formula 1 .摘要翻译： 本发明涉及式1化合物＆lt; CHEM＆gt;及其药学上可接受的盐和溶剂合物，其中A，X，R 1，R 3和R 4如本文所定义。 本发明还涉及通过施用式1化合物和用于治疗含有式1化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及式1化合物的制备方法。
-
10.发明公开PIPERIDINE AND PIPERAZINE DERIVATIVES AS INHIBITORS OF THE ABETA FIBRIL FORMATION 审中-公开哌啶和哌嗪衍生物AS ABETAFIBRILLENBILDUNG抑制剂的
公开(公告)号：EP1150971A1
公开(公告)日：2001-11-07
申请号：EP00906300.9
申请日：2000-02-08
IPC分类号： C07D401/06 , A61K31/435 , A61P25/28 , C07D401/14 , C07D451/08 , C07D221/08 , C07D457/02
CPC分类号： C07D401/06 , C07D221/08 , C07D401/14 , C07D451/08 , C07D457/02
摘要： A compound of formula (I) wherein X is (II) or (III) wherein R' is a group (a), R is a group (e) or (f) wherein n is 0 to 3. In particular the agents of the invention inhibit the formation of β-amyloid (Aβ) peptide into neurotoxic fibrils, thereby acting to prevent or slow down the accumulation of amyloid protein deposits in the brain.
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.013 秒)
