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    PREPARATION OF CYANOPHOSPHONATES FROM PYROPHOSPHATES AND CYANIDE
    1.
    发明公开
    PREPARATION OF CYANOPHOSPHONATES FROM PYROPHOSPHATES AND CYANIDE 失效
    而离去CYANOPHOSPHONATEN焦磷酸盐和氰化物

    公开(公告)号：EP0948504A1

    公开(公告)日：1999-10-13

    申请号：EP97954170.0

    申请日：1997-12-23

    申请人： MONSANTO COMPANY

    发明人： LENNON, Patrick, J. ,  VULFSON, Sergey, G.

    IPC分类号： B01J23 ,  B01J27 ,  C07B61 ,  C07F9

    CPC分类号： C07F9/4062 ,  C07F9/3808 ,  C07F9/3886

    摘要： Phosphorus-containing compounds such as cyanophosphonate derivatives are important precursors for the synthesis of organophosphorus compounds, which have numerous applications, for example, in herbicides, insecticides, fertilizers, flame retardants and plasticizers. Cyanophosphonate derivatives can be further converted to aminomethylphosphonate derivatives, which have been particularly important precursors in the synthesis of N-phosphonomethyglycine, a highly effective commercial herbicide (available under the trade name Roundup) useful for the control of a large variety of weeds. The syntheses of such organophosphorus compounds have commonly used a hologen derivative of phosphorus as a starting material.

    Isoprenoid phosphinylformic acid squalene synthetase inhibitors and method for preparing the same
    5.
    发明公开
    Isoprenoid phosphinylformic acid squalene synthetase inhibitors and method for preparing the same 失效
    从Phosphinylameisensäure角鲨烯合成酶抑制剂和它们的制备方法含有异戊二烯衍生物。

    公开(公告)号：EP0418814A2

    公开(公告)日：1991-03-27

    申请号：EP90117930.9

    申请日：1990-09-18

    申请人： E.R. SQUIBB & SONS, INC.

    发明人： Biller, Scott Adams

    IPC分类号： C07F9/30 ,  A61K31/675 ,  C07F9/48 ,  C07F9/32 ,  C07F9/40

    CPC分类号： C07F9/307 ,  C07F9/3252 ,  C07F9/3886 ,  C07F9/4062

    摘要： Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents, are provided which have the structure
    wherein R 2 is a metal ion, lower alkyl or H;

    R 3 is a metal ion or lower alkyl;
    R is R 1 -(CH 2 ) n -, R 1 -(CH 2 ) m -O- or R 1 -(CH 2 ) m -OCH 2 -, wherein n is 1 to 4 and m is 0 to 3, and
    R 1 is R 5- Q 1 -Q 2 -0 3 - wherein R 5 , Q 1 , Q 2 and Q 3 are as defined herein.

    New intermediates, new methods of preparation and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.

    摘要翻译： 化合物，其是胆固醇生物合成的抑制剂（通过抑制从头角鲨烯生物合成），并因此用作血胆固醇过少剂和动脉粥样硬化剂，提供它们具有结构 worinř<2>是金属离子，低级烷基或H ; [R <3>是金属离子或低级烷基; R x是R <1> - （CH 2）N，R <1> - （CH 2）米O-或R <1> - （CH 2）M-OCH 2，worin n是1〜4，m为0〜3， 和R <1>为R <5> -Q <1> -Q <2> -Q <3> - worinř<5>，Q <1>，Q <2>和Q <3>是如在定义 ， 提供了新的中间体，制备的这样的新方法和用于使用测试，以抑制胆固醇生物合成的化合物的方法。