公开(公告)号：EP4368637A3

公开(公告)日：2024-07-10

申请号：EP24161007.0

申请日：2017-05-19

申请人： Regeneron Pharmaceuticals, Inc.

发明人： VORONINA, Vera ,  MACDONALD, Lynn ,  PRISSETTE, Marine ,  LAI, Ka-Man Venus ,  BADITHE, Ashok ,  MURPHY, Andrew J. ,  DROGUETT, Gustavo ,  FRENDEWEY, David ,  ZAMBROWICZ, Brian

IPC分类号： A01K67/027 ,  C07K16/18 ,  C12N15/90 ,  C12N15/85 ,  C07K16/00

CPC分类号： A01K67/0276 ,  C12N15/90 ,  A01K2217/0020130101 ,  A01K2217/07520130101 ,  A01K2267/0220130101 ,  C07K2317/2120130101 ,  C07K2317/2420130101 ,  C07K2317/3320130101 ,  C07K16/00 ,  A01K67/0278 ,  A01K2207/1520130101 ,  A01K2217/1520130101 ,  A01K2227/10520130101 ,  A01K2267/0120130101 ,  C12N9/6489 ,  C12N15/8509 ,  C12N2015/851820130101 ,  C12Y301/00 ,  C12Y304/24046 ,  C12N2310/2020170501

摘要： Methods and compositions are provided for making non-human animals with reduced tolerance of a foreign antigen of interest and making antigen-binding proteins against that foreign antigen of interest using such animals. The methods and compositions employ CRISPR/Cas9 systems using multiple guide RNAs to reduce or eliminate expression of a self-antigen homologous to or sharing an epitope of interest with the foreign antigen of interest or to reduce or eliminate expression of an epitope on the self-antigen that is shared with the foreign antigen of interest.

公开(公告)号：EP4405486A1

公开(公告)日：2024-07-31

申请号：EP22872082.7

申请日：2022-09-23

申请人： Immunocan Biotech Co. Ltd.

发明人： ZHANG, Jiwei ,  WEI, Yu

IPC分类号： C12N15/12 ,  C12N15/90 ,  C12N15/64 ,  C12N15/85

CPC分类号： C12N2310/2020170501 ,  C12N15/102 ,  C12N9/22 ,  C07K16/00 ,  C12N15/8509 ,  A01K67/0275 ,  C07K2317/2120130101 ,  A01K2227/10520130101 ,  A01K2217/07220130101 ,  A01K2207/1520130101 ,  C12N15/907 ,  C12N2015/851820130101 ,  C12N2800/3020130101 ,  C12N5/166 ,  C12N5/0603 ,  C12N2510/0020130101

公开(公告)号：EP4368637A2

公开(公告)日：2024-05-15

申请号：EP24161007.0

申请日：2017-05-19

申请人： Regeneron Pharmaceuticals, Inc.

发明人： VORONINA, Vera ,  MACDONALD, Lynn ,  PRISSETTE, Marine ,  LAI, Ka-Man Venus ,  BADITHE, Ashok ,  MURPHY, Andrew J. ,  DROGUETT, Gustavo ,  FRENDEWEY, David ,  ZAMBROWICZ, Brian

IPC分类号： C07K16/00

CPC分类号： A01K67/0276 ,  C12N15/90 ,  A01K2217/0020130101 ,  A01K2217/07520130101 ,  A01K2267/0220130101 ,  C07K2317/2120130101 ,  C07K2317/2420130101 ,  C07K2317/3320130101 ,  C07K16/00 ,  A01K67/0278 ,  A01K2207/1520130101 ,  A01K2217/1520130101 ,  A01K2227/10520130101 ,  A01K2267/0120130101 ,  C12N9/6489 ,  C12N15/8509 ,  C12N2015/851820130101 ,  C12Y301/00 ,  C12Y304/24046 ,  C12N2310/2020170501

摘要： Methods and compositions are provided for making non-human animals with reduced tolerance of a foreign antigen of interest and making antigen-binding proteins against that foreign antigen of interest using such animals. The methods and compositions employ CRISPR/Cas9 systems using multiple guide RNAs to reduce or eliminate expression of a self-antigen homologous to or sharing an epitope of interest with the foreign antigen of interest or to reduce or eliminate expression of an epitope on the self-antigen that is shared with the foreign antigen of interest.