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公开(公告)号：EP2986739B1
公开(公告)日：2018-04-04
申请号：EP14784689.3
申请日：2014-04-15
发明人： FRENDEWEY, David , DROGUETT, Gustavo , KOSS, Matthew , THURSTON, Gavin , YANCOPOULOS, George, D.
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178
摘要： Compositions and methods for determining circulating biomolecules before, during, and/or after treatment of a patient with an anti-cancer or anti-tumor drug (or putative drug) are described. Methods of treatments based on the compositions and methods described herein are also provided. Noninvasive methods and kits are provided for assessing the efficacy of an anti-cancer therapy for killing or damaging cancer cells. Embodiments are used to determine the cancer-killing efficacy of an anti-cancer drug in a patient, to optimize the selection of an anti-cancer drug for treatment of a patient, to adjust the dosage of an anti-cancer drug for treatment of a particular cancer in a patient and for identifying useful anti-cancer therapeutics for any one particular type of cancer.
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2.发明公开METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATIONS AND METHODS OF USE 审中-公开方法和组合物进行有针对性的遗传修饰和方法使用
公开(公告)号：EP3161128A2
公开(公告)日：2017-05-03
申请号：EP15745288.9
申请日：2015-06-26
发明人： FRENDEWEY, David , DROGUETT, Gustavo , GAGLIARDI, Anthony , KUNO, Junko , AUERBACH, Wojtek , VALENZUELA, David M.
IPC分类号： C12N5/0735
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2217/075 , A01K2227/105 , A01K2267/02 , A01K2267/0393 , C12N5/0606 , C12N15/907 , C12N2500/60 , C12N2517/00
摘要： Methods and compositions are provided for generating targeted genetic modifications on the Y chromosome or a challenging target locus. Compositions include an in vitro culture comprising an XY pluripotent and/or totipotent animal cell (i.e., XY ES cells or XY iPS cells) having a modification that decreases the level and/or activity of an Sry protein; and, culturing these cells in a medium that promotes development of XY F0 fertile females. Such compositions find use in various methods for making a fertile female XY non-human mammal in an F0 generation.
摘要翻译： 提供了用于在Y染色体或一个具有挑战性的靶基因座上产生有针对性的遗传修饰的方法和组合物。 组合物包括在体外培养多能XY和/或全能动物细胞具有修饰确实降低的Sry基因蛋白的水平和/或活性（即，XY ES细胞或iPS细胞XY）的，包括： 并且，在论文中培养细胞并促进XY F0育女性的发展。 搜索组合物可用于在F0代能制备能育的雌性XY非人类的哺乳动物的多种方法使用。
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公开(公告)号：EP4368637A2
公开(公告)日：2024-05-15
申请号：EP24161007.0
申请日：2017-05-19
发明人： VORONINA, Vera , MACDONALD, Lynn , PRISSETTE, Marine , LAI, Ka-Man Venus , BADITHE, Ashok , MURPHY, Andrew J. , DROGUETT, Gustavo , FRENDEWEY, David , ZAMBROWICZ, Brian
IPC分类号： C07K16/00
CPC分类号： A01K67/0276 , C12N15/90 , A01K2217/0020130101 , A01K2217/07520130101 , A01K2267/0220130101 , C07K2317/2120130101 , C07K2317/2420130101 , C07K2317/3320130101 , C07K16/00 , A01K67/0278 , A01K2207/1520130101 , A01K2217/1520130101 , A01K2227/10520130101 , A01K2267/0120130101 , C12N9/6489 , C12N15/8509 , C12N2015/851820130101 , C12Y301/00 , C12Y304/24046 , C12N2310/2020170501
摘要： Methods and compositions are provided for making non-human animals with reduced tolerance of a foreign antigen of interest and making antigen-binding proteins against that foreign antigen of interest using such animals. The methods and compositions employ CRISPR/Cas9 systems using multiple guide RNAs to reduce or eliminate expression of a self-antigen homologous to or sharing an epitope of interest with the foreign antigen of interest or to reduce or eliminate expression of an epitope on the self-antigen that is shared with the foreign antigen of interest.
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公开(公告)号：EP3732291A1
公开(公告)日：2020-11-04
申请号：EP19836402.8
申请日：2019-12-13
发明人： KAJIMURA, Daisuke , SHARMA-KANNING, Aarti , DUBOSE, Brittany , DROGUETT, Gustavo , SIAO, Chia-Jen , KUNO, Junko , FRENDEWEY, David , ZAMBROWICZ, Brian
IPC分类号： C12N15/10 , A01K67/027 , C12N15/11
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公开(公告)号：EP3457840A1
公开(公告)日：2019-03-27
申请号：EP17729952.6
申请日：2017-05-19
发明人： VORONINA, Vera , MACDONALD, Lynn , PRISSETTE, Marine , LAI, Ka-Man Venus , BADITHE, Ashok , MURPHY, Andrew J. , DROGUETT, Gustavo , FRENDEWEY, David , ZAMBROWICZ, Brian
IPC分类号： A01K67/027 , C07K16/18 , C12N15/90 , C12N15/85 , C07K16/00
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公开(公告)号：EP3349573A1
公开(公告)日：2018-07-25
申请号：EP16778528.6
申请日：2016-09-16
发明人： SCHMAHL, Jennifer , FRENDEWEY, David , KUNO, Junko , SIAO, Chia-Jen , DROGUETT, Gustavo , BAI, Yu , AUERBACH, Wojtek
IPC分类号： A01K67/027 , C12N5/0735
CPC分类号： A01K67/0271 , A01K2207/12 , A01K2207/35 , A01K2227/105 , A01K2267/02 , C12N5/0606 , C12Q1/6876 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5073
摘要： Methods and compositions are provided for generating F0 fertile XY female animals. The methods and compositions involve making XY pluripotent or totipotent animal cells, in vitro cell cultures, or embryos that are capable of producing a fertile female XY animal in an F0 generation. Such cells, embryos, and animals can be made by silencing a region of the Y chromosome. Optionally, the cells can also be cultured in feminizing medium such as a low-osmolality medium and/or can be modified to decrease the level and/or activity of an Sry protein. Methods and compositions are also provided for silencing a region of the Y chromosome in an XY pluripotent or totipotent animal cell, or in vitro cell cultures, embryos, or animals derived therefrom, by maintaining an XY pluripotent or totipotent animal cell in a feminizing medium. Methods and compositions are also provided for maintaining a population of XY pluripotent or totipotent animal cells in a feminizing medium and selecting cells or clones having increased capabilities for producing a fertile female XY animal in an F0 generation. Methods and compositions are also provided for screening for compounds with feminizing activity or for optimizing concentrations of components in feminizing media.
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公开(公告)号：EP4368637A3
公开(公告)日：2024-07-10
申请号：EP24161007.0
申请日：2017-05-19
发明人： VORONINA, Vera , MACDONALD, Lynn , PRISSETTE, Marine , LAI, Ka-Man Venus , BADITHE, Ashok , MURPHY, Andrew J. , DROGUETT, Gustavo , FRENDEWEY, David , ZAMBROWICZ, Brian
IPC分类号： A01K67/027 , C07K16/18 , C12N15/90 , C12N15/85 , C07K16/00
CPC分类号： A01K67/0276 , C12N15/90 , A01K2217/0020130101 , A01K2217/07520130101 , A01K2267/0220130101 , C07K2317/2120130101 , C07K2317/2420130101 , C07K2317/3320130101 , C07K16/00 , A01K67/0278 , A01K2207/1520130101 , A01K2217/1520130101 , A01K2227/10520130101 , A01K2267/0120130101 , C12N9/6489 , C12N15/8509 , C12N2015/851820130101 , C12Y301/00 , C12Y304/24046 , C12N2310/2020170501
摘要： Methods and compositions are provided for making non-human animals with reduced tolerance of a foreign antigen of interest and making antigen-binding proteins against that foreign antigen of interest using such animals. The methods and compositions employ CRISPR/Cas9 systems using multiple guide RNAs to reduce or eliminate expression of a self-antigen homologous to or sharing an epitope of interest with the foreign antigen of interest or to reduce or eliminate expression of an epitope on the self-antigen that is shared with the foreign antigen of interest.
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8.发明公开
公开(公告)号：EP4073251A1
公开(公告)日：2022-10-19
申请号：EP20829269.8
申请日：2020-12-10
发明人： FISHILEVICH, Elane , MILSTEIN, Stuart , BROWN, Kirk , ZIMMERMANN, Tracy , MCININCH, James, D. , FRENDEWEY, David , CHIAO, Eric , SHARMA-KANNING, Aarti , GAGLIARDI, Anthony , DROGUETT, Gustavo , DUBOSE, Brittany , ZAMBROWICZ, Brian
IPC分类号： C12N15/113 , A61K31/713 , A61P25/28
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公开(公告)号：EP3521437A1
公开(公告)日：2019-08-07
申请号：EP19161085.6
申请日：2015-11-20
发明人： MURPHY, Andrew , FRENDEWEY, David , LAI, Ka-Man , AUERBACH, Wojtek , DROGUETT, Gustavo , GAGLIARDI, Anthony , VALENZUELA, David , VORONINA, Vera , MACDONALD, Lynn , YANCOPOULOS, George
IPC分类号： C12N15/90
摘要： Compositions and methods are provided for creating and promoting biallelic targeted modifications to genomes within cells and for producing non-human animals comprising the modified genomes. Also provided are compositions and methods for modifying a genome within a cell that is heterozygous for an allele to become homozygous for that allele. The methods make use of Cas proteins and two or more guide RNAs that target different locations within the same genomic target locus. Also provided are methods of identifying cells with modified genomes.
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公开(公告)号：EP3221457B1
公开(公告)日：2019-03-20
申请号：EP15804289.5
申请日：2015-11-20
发明人： MURPHY, Andrew J. , FRENDEWEY, David , LAI, Ka-Man Venus , AUERBACH, Wojtek , DROGUETT, Gustavo , GAGLIARDI, Anthony , VALENZUELA, David M. , VORONINA, Vera , MACDONALD, Lynn , YANCOPOULOS, George D.
IPC分类号： C12N15/90
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