公开(公告)号：EP2260108A4

公开(公告)日：2011-09-28

申请号：EP09718303

申请日：2009-03-03

申请人： UNIV KANSAS STATE

发明人： BOSSMANN STEFAN H ,  TROYER DERYL L ,  BASEL MATTHEW T

IPC分类号： C12Q1/37 ,  A61K33/26 ,  B82B1/00 ,  G01N33/53 ,  G01N33/543

CPC分类号： A61K49/0067 ,  A61K49/0036 ,  A61K49/0056 ,  A61K49/0065 ,  A61K49/0093 ,  B82Y15/00 ,  C07K5/1021 ,  C07K7/06 ,  C07K7/08 ,  C12Q1/37 ,  G01N33/588 ,  G01N2800/7028 ,  Y10S977/773 ,  Y10S977/774 ,  Y10S977/92

摘要： The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence specific for the target protease. Cleavage of the sequence by the target protease can be detected visually or using various sensors, and the diagnostic results can be correlated with cancer prognosis.

公开(公告)号：EP2033279A4

公开(公告)日：2010-09-08

申请号：EP07845168

申请日：2007-06-21

申请人： UNIV KANSAS STATE

发明人： CHANG ZENGHU ,  LI CHENGQUAN ,  MOON ERIC

IPC分类号： H01S3/13

CPC分类号： H01S3/0057 ,  H01S2301/08

公开(公告)号：EP1091801A4

公开(公告)日：2006-05-10

申请号：EP99927082

申请日：1999-05-18

申请人： UNIV KANSAS STATE

发明人： KLABUNDE KENNETH J ,  KOPER OLGA ,  KHALEEL ABBAS

IPC分类号： B01J20/02 ,  B01D53/04 ,  B01J20/04 ,  B01J20/06 ,  B01J20/28 ,  B01J20/00 ,  B01J20/10 ,  B27N3/00 ,  B27N3/18

CPC分类号： B01D53/02 ,  B01D2253/10 ,  B01D2253/112 ,  B01D2253/304 ,  B01D2253/306 ,  B01D2253/308 ,  B01D2257/2064 ,  B01D2257/302 ,  B01D2257/404 ,  B01D2257/502 ,  B01D2257/70 ,  B01D2257/7027 ,  B01D2258/0225 ,  B01J20/041 ,  B01J20/06 ,  B01J20/28014 ,  B01J20/2803 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28095 ,  B01J20/3021 ,  B01J20/3035

摘要： Pelletized adsorbent compositions and methods of adsorbing toxic target compounds are provided for the destructive adsorption or chemisorption of toxic or undesired compounds. The pelletized adsorbents are formed by pressing together powder nanocrystalline particles comprising a metal hydroxide or a metal oxide at pressures of from about 50 psi to about 6000 psi to form discrete self-sustaining bodies. The pelletized bodies should retain at least about 25 % of the surface area/unit mass and total pore volume of the starting metal particles.

公开(公告)号：EP1113875A4

公开(公告)日：2004-07-28

申请号：EP99942045

申请日：1999-08-12

申请人： UNIV KANSAS STATE

发明人： KLABUNDE KENNETH J ,  SUN NAIJIAN

IPC分类号： B01J21/10 ,  B01J23/02 ,  B01J23/04 ,  B01J27/06 ,  B01J35/02 ,  B01J35/10 ,  B01J37/22 ,  B01J37/24 ,  C01B13/14 ,  C01F5/02 ,  C01F11/02 ,  C07B61/00 ,  C07C2/10 ,  C07C2/72 ,  C07C5/13 ,  C07C5/22 ,  C07C5/25 ,  C07C9/16 ,  C07C11/10 ,  C07C15/02 ,  C07C17/10 ,  B01J27/10 ,  C07C2/02 ,  C07C17/02

CPC分类号： B01J27/138 ,  B01J21/10 ,  B01J23/02 ,  B01J23/04 ,  B01J27/06 ,  B01J35/002 ,  B01J35/023 ,  B01J35/10 ,  B01J35/1019 ,  B01J35/1023 ,  B01J37/0238 ,  B01J37/033 ,  B01J37/10 ,  B01J37/22 ,  B01J37/24 ,  B82Y30/00 ,  C01B13/14 ,  C01B13/145 ,  C01F5/02 ,  C01F11/02 ,  C01P2002/60 ,  C01P2002/88 ,  C01P2004/64 ,  C01P2006/12 ,  C01P2006/22 ,  C07C2/10 ,  C07C2/72 ,  C07C5/2512 ,  C07C17/10 ,  C07C2521/10 ,  C07C2523/04 ,  C07C11/10 ,  C07C11/107 ,  C07C19/01 ,  C07C19/075 ,  C07C19/07

摘要： Particulate metal oxide compositions having reactive atoms stabilized on particulate surfaces and methods for reacting the compositions with saturated and unsaturated species are provided. The preferred particulate metal oxides of the compositions are nanocrystalline MgO and CaO with an average crystallite size of up to about 20 nm. The preferred reactive atoms of the compositions are atoms of the halogens and Group I metals. In one embodiment, chlorine atoms are stabilized on the surface of nanocrystalline MgO thus forming a composition which is capable of halogenating compounds, both saturated and unsaturated, in the absence of UV light and elevated reaction temperatures.

公开(公告)号：EP0944419A4

公开(公告)日：2003-09-10

申请号：EP97938457

申请日：1997-08-20

申请人： UNIV KANSAS STATE

发明人： KLABUNDE KENNETH J

IPC分类号： B01D53/04 ,  B01D53/10 ,  B01D53/46 ,  B01J20/04 ,  B01J20/06 ,  B01J20/08 ,  B01D15/00 ,  B01D53/38 ,  B01D53/40 ,  B01D53/44 ,  B01D53/81 ,  B01J20/28

CPC分类号： B01D53/02 ,  B01D53/10 ,  B01D53/46 ,  B01D2253/112 ,  B01D2253/306 ,  B01D2253/308 ,  B01D2253/311 ,  B01D2258/0225 ,  B01J20/041 ,  B01J20/06 ,  B01J20/08 ,  B01J20/28007 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28083 ,  B01J20/30 ,  B82Y30/00

摘要： Methods for adsorbing toxic target chemical compounds are provided wherein such compounds (either as gases, liquids or solids) are contacted with nanoscale oxide adsorbents, such as MgO and CaO, preferably at ambient temperatures and at atmospheric pressure. The preferred adsorbents have an average particle size of from about 1-20 nm, and have a total pore volume of at least about 0.5 cc/g.

公开(公告)号：EP2760827A4

公开(公告)日：2015-06-24

申请号：EP12837222

申请日：2012-09-27

申请人： UNIV KANSAS STATE ,  UNIV OHIO STATE ,  UNIV WICHITA STATE

发明人： CHANG KYEONG-OK ,  KIM YUNJEONG ,  GROUTAS WILLIAM C ,  HUA DUY ,  SAIF LINDA J

IPC分类号： C07D207/27 ,  A61K31/4015 ,  A61K31/422 ,  A61K31/427 ,  A61K31/5377 ,  A61K45/06 ,  A61P31/12

CPC分类号： A61K31/5377 ,  A61K31/4015 ,  A61K31/422 ,  A61K31/427 ,  A61K38/06 ,  A61K45/06 ,  C07D207/27 ,  C12N2770/16011 ,  C12N2770/20011 ,  C12N2770/32111 ,  C12N2770/32311 ,  C12N2770/32411 ,  C12N2770/32611

摘要： Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.

公开(公告)号：EP2114125A4

公开(公告)日：2010-09-01

申请号：EP08705880

申请日：2008-01-11

申请人： UNIV KANSAS STATE

发明人： TUINSTRA MITCHELL R ,  AL-KHATIB KASSIM

IPC分类号： A01H1/00 ,  A01H5/00 ,  A01H5/10 ,  C12N15/29

CPC分类号： C12N15/8274 ,  A01H5/00 ,  A01H5/10 ,  C12N9/88

摘要： The present invention provides for compositions and methods for producing crop plants that are resistant to herbicides. In particular, the present invention provides for sorghum plants, plant tissues and plant seeds that contain altered acetyl-CoA carboxylase (ACC) genes and proteins that are resistant to inhibition by herbicides that normally inhibit the activity of the ACC protein.

公开(公告)号：EP1735005A4

公开(公告)日：2009-11-11

申请号：EP05732178

申请日：2005-04-06

申请人： UNIV KANSAS STATE

发明人： DROUILLARD JAMES S ,  HERALD THOMAS J ,  GREENQUIST MATTHEW

IPC分类号： A61K47/00 ,  A23K1/00 ,  A23K1/16 ,  A23K1/18 ,  A61K9/16

CPC分类号： A23L1/0029 ,  A23K20/147 ,  A23K40/35 ,  A23K50/10 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/1658 ,  A61K9/5052 ,  A23V2200/224 ,  A23V2250/5486 ,  A23V2250/6406 ,  A23V2250/022

公开(公告)号：EP0999738A4

公开(公告)日：2002-06-12

申请号：EP98922094

申请日：1998-05-06

申请人： UNIV KANSAS STATE

发明人： LI YI

IPC分类号： C12N9/02 ,  C12N9/10 ,  C12N15/82 ,  A01H5/00 ,  A01H5/10 ,  C12N5/14 ,  C12N15/31 ,  C12N15/52

CPC分类号： C12N9/1085 ,  C12N9/0069 ,  C12N15/8233 ,  C12N15/8235 ,  C12N15/8287 ,  C12N15/8294 ,  C12N15/8295 ,  C12N15/8297

摘要： The present invention provides methods and DNA constructs for the genetic engineering of plant cells to produce plants which produce substantially seedless fruit in the absence of exogenous growth factors (auxins or cytokinins) and in the absence of pollination. The substantially seedless fruits produced by the methods described herein are about the size of wildtype seeded fruit (or somewhat larger) and these fruits are equal to or superior to the wildtype seeded fruit with respect to solid content and flavor. The seedless fruits of the present invention are produced in transgenic plants which contain and express auxin or cytokinin biosynthetic genes, e.g., tryptophan oxygenase or isopentenyl transferase coding sequences expressed under the regulatory control of sequences directing preferential or tissue specific expression of a downstream gene in the ovaries or developing fruit.

公开(公告)号：EP0690679A4

公开(公告)日：1996-02-28

申请号：EP94912294

申请日：1994-03-23

申请人： UNIV KANSAS STATE

发明人： TOKACH MIKE D ,  NELSSEN JIM L ,  GOODBAND ROBERT D

IPC分类号： A23K1/16 ,  A23K1/18 ,  A23L1/00 ,  A23L1/18

CPC分类号： A23K50/00 ,  A23K20/142 ,  Y10S426/807

摘要： Improved, valine-supplemented sow lactation diets are provided which increase litter and weaning weights, particularly in the case of high producing sows. The diets of the invention include from about 12-30 % by weight of total protein (e.g., from corn and soy), a total lysine content of about 0.75 % by weight, and sufficient valine to give a valine: lysine ratio of at least about 0.83:1.