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公开(公告)号：EP1716858B9
公开(公告)日：2009-08-12
申请号：EP05025974.6
申请日：2000-09-18
发明人： Bell, John Cameron , Sonenberg, Nahum , Stojdl, David Francis , Brown, Earl Garnet , Atkins, Harold Lawrence , Marius, Ricardo Marcellus , Lichty, Brian Dennis , Knowles, Shane Brendan
CPC分类号： C12N7/00 , A01K2267/0331 , A61K35/766 , A61K38/21 , C07K14/005 , C07K2319/00 , C07K2319/21 , C12N2760/20221 , C12N2760/20222 , C12N2760/20232 , C12N2760/20251 , C12N2760/20261 , A61K2300/00
摘要： The present invention is directed to a method of reducing the viability of a tumor cell involving administering a virus that is not a common human pathogen to the tumor cell. Preferably, the virus exhibits differential susceptibility, in that normal cells are not affected by the virus. This differential susceptibility is more pronounced in the presence of interferon. The tumor cell is characterised by having low levels, or no PKR activity, or as being PKR-/-, STAT1-/- or both PKR-/- and STAT-/-. The virus is selected from the group consisting of Rhabdovirus and picornavirus, and preferably is vesicular stomatitis virus (VSV) or a derivative thereof.
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2.发明公开Mutant vesicular stomatitis viruses and use thereof 有权Mutierte Viren dervesikulärenStomatitis und deren Verwendung
公开(公告)号：EP2039773A1
公开(公告)日：2009-03-25
申请号：EP08168529.9
申请日：2004-03-29
IPC分类号： C12N15/86 , C07K14/145 , C12N7/04 , A61K39/205
CPC分类号： C07K14/005 , A61K35/766 , A61K39/12 , A61K39/205 , A61K39/39 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K2319/60 , C12N7/00 , C12N15/86 , C12N2760/20222 , C12N2760/20232 , C12N2760/20234 , C12N2760/20243 , C12N2760/20261 , C12N2830/00 , C12N2830/85
摘要： An oncolytic vesicular stomatitis virus (VSV) having a ΔM51 mutation in the matrix (M) protein for use in the treatment of cancer is provided.
摘要翻译： 提供了在用于治疗癌症的基质（M）蛋白中具有“M51突变”的溶瘤性水泡性口炎病毒（VSV）。
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公开(公告)号：EP1606411B1
公开(公告)日：2008-12-10
申请号：EP04723949.6
申请日：2004-03-29
IPC分类号： C12N15/86 , C07K14/145 , C12N7/04 , A61K39/205
CPC分类号： C07K14/005 , A61K35/766 , A61K39/12 , A61K39/205 , A61K39/39 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K2319/60 , C12N7/00 , C12N15/86 , C12N2760/20222 , C12N2760/20232 , C12N2760/20234 , C12N2760/20243 , C12N2760/20261 , C12N2830/00 , C12N2830/85
摘要： An oncolytic vesicular stomatitis virus (VSV) having a ”M51 mutation in the matrix (M) protein for use in the treatment of cancer is provided.
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4.发明公开MANIPULATION OF NEGATIVE STRANDED RNA VIRUSES BY REARRANGEMENT OF THEIR GENES AND USES THEREOF 审中-公开重排的基因MANIPULATIONMINUSSTRÄNGIGERRNA病毒及其用途（8时01分03秒）
公开(公告)号：EP1292329A4
公开(公告)日：2005-11-16
申请号：EP01948594
申请日：2001-06-22
发明人： WERTZ GAIL W , BALL L ANDREW
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K39/12 , A61K39/155 , A61K39/205 , A61P37/02 , C07K14/08 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/40 , C12N15/86
CPC分类号： A61K39/155 , A61K39/00 , A61K39/12 , A61K39/205 , A61K2039/5254 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2760/20161 , C12N2760/20222 , C12N2760/20234 , C12N2760/20243 , C12N2760/20261
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5.发明公开MANIPULATION OF NEGATIVE STRANDED RNA VIRUSES BY REARRANGEMENT OF THEIR GENES AND USES THEREOF 审中-公开重排的基因MANIPULATIONMINUSSTRÄNGIGERRNA病毒及其用途（8时01分03秒）
公开(公告)号：EP1292329A1
公开(公告)日：2003-03-19
申请号：EP01948594.5
申请日：2001-06-22
发明人： WERTZ, Gail, W. , BALL, L., Andrew
IPC分类号： A61K39/12
CPC分类号： A61K39/155 , A61K39/00 , A61K39/12 , A61K39/205 , A61K2039/5254 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2760/20161 , C12N2760/20222 , C12N2760/20234 , C12N2760/20243 , C12N2760/20261
摘要： The present invention provides a method of increasing expression of a promoter distal gene in a virus of the order Mononegavirales, and a recombinant virus constructed by such method. Also provided is a method of attenuating a virus of the order Mononegavirales, and of constructing an attenuated virus useful for a vaccine.
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6.发明公开
公开(公告)号：EP0197554A3
公开(公告)日：1987-03-25
申请号：EP86104849
申请日：1986-04-09
发明人： Chandra, Sudhish , Feldman, Fred
IPC分类号： A61L02/16
CPC分类号： C12N7/00 , A61K35/16 , A61K38/005 , A61L2/0088 , A61L2/0094 , C07K14/755 , C12N2760/20261 , Y10S435/803 , Y10S435/815
摘要： A method for treating a biological or pharmaceutical product to inactivate viruses and pyrogens therein comprising the steps of adsorbing said product onto a solid phase; treating the adsorbed product with a virus or pyrogen inactivating agent; separating the solid phase and quantitatively removing the residual inactivating agent therefrom; and recovering said product.
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公开(公告)号：EP2039773B1
公开(公告)日：2011-12-28
申请号：EP08168529.9
申请日：2004-03-29
IPC分类号： C12N15/86 , C07K14/145 , C12N7/04 , A61K39/205
CPC分类号： C07K14/005 , A61K35/766 , A61K39/12 , A61K39/205 , A61K39/39 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K2319/60 , C12N7/00 , C12N15/86 , C12N2760/20222 , C12N2760/20232 , C12N2760/20234 , C12N2760/20243 , C12N2760/20261 , C12N2830/00 , C12N2830/85
摘要： An oncolytic vesicular stomatitis virus (VSV) having a ”M51 mutation in the matrix (M) protein for use in the treatment of cancer is provided.
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公开(公告)号：EP1716858A2
公开(公告)日：2006-11-02
申请号：EP05025974.6
申请日：2000-09-18
发明人： Bell, John Cameron , Sonenberg, Nahum , Stojdl, David Francis , Brown, Earl Garnet , Atkins, Harold Lawrence , Marius, Ricardo Marcellus , Lichty, Brian Dennis , Knowles, Shane Brendan
IPC分类号： A61K35/76
CPC分类号： C12N7/00 , A01K2267/0331 , A61K35/766 , A61K38/21 , C07K14/005 , C07K2319/00 , C07K2319/21 , C12N2760/20221 , C12N2760/20222 , C12N2760/20232 , C12N2760/20251 , C12N2760/20261 , A61K2300/00
摘要： The present invention is directed to a method of reducing the viability of a tumor cell involving administering a virus that is not a common human pathogen to the tumor cell. Preferably, the virus exhibits differential susceptibility, in that normal cells are not affected by the virus. This differential susceptibility is more pronounced in the presence of interferon. The tumor cell is characterised by having low levels, or no PKR activity, or as being PKR-/-, STAT1-/- or both PKR-/- and STAT-/-. The virus is selected from the group consisting of Rhabdovirus and picornavirus, and preferably is vesicular stomatitis virus (VSV) or a derivative thereof.
摘要翻译： 本发明涉及一种降低肿瘤细胞生存能力的方法，涉及向肿瘤细胞施用不是常见的人类病原体的病毒。 优选地，病毒表现出差异的易感性，因为正常细胞不受病毒的影响。 这种差异敏感性在干扰素存在下更显着。 肿瘤细胞的特征在于具有低水平或没有PKR活性，或PKR - / - ，STAT1 - / - 或PKR - / - 和 - STAT - / - 两者。 病毒选自由弹状病毒和小RNA病毒组成的组，优选为水泡性口炎病毒（VSV）或其衍生物。
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公开(公告)号：EP1218019B1
公开(公告)日：2006-03-08
申请号：EP00965106.8
申请日：2000-09-18
发明人： BELL, John, Cameron , SONENBERG, Nahum , STOJDL, David, Francis , BROWN, Earl, Garnet , ATKINS, Harold, Lawrence , MARIUS, Ricardo, Marcellus , LICHTY, Brian, Dennis , KNOWLES, Shane, Brendan
CPC分类号： C12N7/00 , A01K2267/0331 , A61K35/766 , A61K38/21 , C07K14/005 , C07K2319/00 , C07K2319/21 , C12N2760/20221 , C12N2760/20222 , C12N2760/20232 , C12N2760/20251 , C12N2760/20261 , A61K2300/00
摘要： The present invention is directed to a method of reducing the viability of a tumor cell involving administering a virus that is not a common human pathogen to the tumor cell. Preferably, the virus exhibits differential susceptibility, in that normal cells are not affected by the virus. This differential susceptibility is more pronounced in the presence of interferon. The tumor cell is characterised by having low levels, or no PKR activity, or as being PKR-/-, STAT1-/- or both PKR-/- and STAT-/-. The virus is selected from the group consisting of Rhabdovirus and picornavirus, and preferably is vesicular stomatitis virus (VSV) or a derivative thereof.
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公开(公告)号：EP1606411A1
公开(公告)日：2005-12-21
申请号：EP04723949.6
申请日：2004-03-29
IPC分类号： C12N15/86 , C07K14/145 , C12N7/04 , A61K39/205
CPC分类号： C07K14/005 , A61K35/766 , A61K39/12 , A61K39/205 , A61K39/39 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K2319/60 , C12N7/00 , C12N15/86 , C12N2760/20222 , C12N2760/20232 , C12N2760/20234 , C12N2760/20243 , C12N2760/20261 , C12N2830/00 , C12N2830/85
摘要： An oncolytic vesicular stomatitis virus (VSV) having a ”M51 mutation in the matrix (M) protein for use in the treatment of cancer is provided.
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