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    POXVIRUS-PLASMODIUM RECOMBINANTS, COMPOSITIONS CONTAINING SUCH RECOMBINANTS, USES THEREOF, AND METHODS OF MAKING AND USING SAME
    4.
    发明公开
    POXVIRUS-PLASMODIUM RECOMBINANTS, COMPOSITIONS CONTAINING SUCH RECOMBINANTS, USES THEREOF, AND METHODS OF MAKING AND USING SAME 审中-公开
    天花病毒PLASMODIUMREKOMBINANTEN，用这种重组组合物，体和方法使用的生产和它们的用途

    公开(公告)号：EP3089756A1

    公开(公告)日：2016-11-09

    申请号：EP14877230.4

    申请日：2014-12-19

    申请人： V-Core Technologies, Inc.

    发明人： PAOLETTI, Enzo ,  WEINBERG, Randall, L. ,  GOEBEL, Scott, J.

    IPC分类号： A61K39/275 ,  A61K39/015 ,  A61P37/00

    CPC分类号： C12N7/00 ,  A61K39/015 ,  A61K39/275 ,  A61K2039/5256 ,  C12N15/86 ,  C12N2710/24021 ,  C12N2710/24034 ,  C12N2710/24122 ,  C12N2710/24134 ,  C12N2710/24143 ,  Y02A50/412

    摘要： The invention provides a recombinant or synthetic or engineered or non-naturally occurring poxvirus that contains and expresses DNA encoding a heterologous or exogenous antigen, epitope or immunogen and Flagellin or an operable binding portion thereof. The poxvirus can contain or be engineered to contain and express vaccinia host range gene K1L. The poxvirus can be attenuated as to mammals, e.g., NYVAC, NYVAC.1, NYVAC.2, avipox, canarypox, fowlpox, ALVAC, TROVAC, MVA, or MVA-BN. The invention also provides methods for inducing an immunological response involving the poxvirus, and compositions containing the poxvirus. The antigen, epitope or immunogen that the poxvirus expresses can be at least one Plasmodium antigen. The Plasmodium antigen(s), epitope(s) or immunogen(s) can be SERA, ABRA, Pfhsp70, AMA-1, Pfs25, Pfs16, CSP, PfSSP2, LSA-1 repeatless, MSA-1, AMA-1 or combination(s) thereof. Advantageously the poxvirus contains DNA coding for and expresses Plasmodium antigen(s) CSP, PfSSP2, LSA-1-repeatless, MSA-1, SERA, AMA-1 and Pfs25. Also, advantageously, the poxvirus is a NYVAC poxvirus. The invention thus also provides an anti-malarial immunogenic or immunological compositions comprising the poxvirus, and methods for inducing an immunogenic or immunological response against malaria or Plasmodium in a mammal comprising administering to the mammal the poxvirus or an immunological or immunogenic composition containing the poxvirus. The mammal can be a human.

    POXVIRUS-PLASMODIUM RECOMBINANTS, COMPOSITIONS CONTAINING SUCH RECOMBINANTS, USES THEREOF, AND METHODS OF MAKING AND USING SAME
    10.
    发明公开
    POXVIRUS-PLASMODIUM RECOMBINANTS, COMPOSITIONS CONTAINING SUCH RECOMBINANTS, USES THEREOF, AND METHODS OF MAKING AND USING SAME 审中-公开
    POCKENVIRUS-PLASMODIUMREKOMBINANTEN，ZUSAMMENSETZUNGEN MIT SOLCHEN REKOMBINANTEN，VERWENDUNGEN DAVON UND VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON

    公开(公告)号：EP3089756A4

    公开(公告)日：2017-08-16

    申请号：EP14877230

    申请日：2014-12-19

    申请人： V-CORE TECH INC

    发明人： PAOLETTI ENZO ,  WEINBERG RANDALL L ,  GOEBEL SCOTT J

    IPC分类号： A61K39/275 ,  A61K39/015 ,  A61P37/00 ,  C12N15/86

    CPC分类号： C12N7/00 ,  A61K39/015 ,  A61K39/275 ,  A61K2039/5256 ,  C12N15/86 ,  C12N2710/24021 ,  C12N2710/24034 ,  C12N2710/24122 ,  C12N2710/24134 ,  C12N2710/24143

    摘要： The invention provides a recombinant or synthetic or engineered or non-naturally occurring poxvirus that contains and expresses DNA encoding a heterologous or exogenous antigen, epitope or immunogen and Flagellin or an operable binding portion thereof. The poxvirus can contain or be engineered to contain and express vaccinia host range gene K1L. The poxvirus can be attenuated as to mammals, e.g., NYVAC, NYVAC.1, NYVAC.2, avipox, canarypox, fowlpox, ALVAC, TROVAC, MVA, or MVA-BN. The invention also provides methods for inducing an immunological response involving the poxvirus, and compositions containing the poxvirus. The antigen, epitope or immunogen that the poxvirus expresses can be at least one Plasmodium antigen. The Plasmodium antigen(s), epitope(s) or immunogen(s) can be SERA, ABRA, Pfhsp70, AMA-1, Pfs25, Pfs16, CSP, PfSSP2, LSA-1 repeatless, MSA-1, AMA-1 or combination(s) thereof. Advantageously the poxvirus contains DNA coding for and expresses Plasmodium antigen(s) CSP, PfSSP2, LSA-1-repeatless, MSA-1, SERA, AMA-1 and Pfs25. Also, advantageously, the poxvirus is a NYVAC poxvirus. The invention thus also provides an anti-malarial immunogenic or immunological compositions comprising the poxvirus, and methods for inducing an immunogenic or immunological response against malaria or Plasmodium in a mammal comprising administering to the mammal the poxvirus or an immunological or immunogenic composition containing the poxvirus. The mammal can be a human.

    摘要翻译： 本发明提供了包含和表达编码异源或外源抗原，表位或免疫原和鞭毛蛋白或其可操作的结合部分的DNA的重组或合成或工程化或非天然存在的痘病毒。 痘病毒可以含有或被工程化为含有和表达牛痘宿主范围基因K1L。 关于哺乳动物，例如NYVAC，NYVAC.1，NYVAC.2，禽痘病毒，金丝雀痘病毒，禽痘病毒，ALVAC，TROVAC，MVA或MVA-BN，痘病毒可以减毒。 本发明还提供了诱导涉及痘病毒的免疫学应答的方法，以及含有痘病毒的组合物。 痘病毒表达的抗原，表位或免疫原可以是至少一种疟原虫抗原。 疟原虫抗原，表位或免疫原可以是SERA，ABRA，Pfhsp70，AMA-1，Pfs25，Pfs16，CSP，PfSSP2，LSA-1无重复，MSA-1，AMA-1或组合 （s）。 有利的是，痘病毒含有编码和表达疟原虫抗原CSP，PfSSP2，LSA-1-重复序列，MSA-1，SERA，AMA-1和Pfs25的DNA。 而且，有利地，痘病毒是NYVAC痘病毒。 本发明因此还提供了包含痘病毒的抗疟疾免疫原性或免疫学组合物，以及在哺乳动物中诱导针对疟疾或疟原虫的免疫原性或免疫应答的方法，包括给予哺乳动物痘病毒或含有痘病毒的免疫学或免疫原性组合物。 哺乳动物可以是人类。