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1.发明公开NEW MARKERS FOR SEVERE PROGRESSION OF IDIOPATHIC SCOLIOSIS AND USES THEREOF TO STRATIFY SCOLIOTIC PATIENTS AND PREDICT THE RISK OF DEVELOPING SCOLIOSIS 有权特发性脊柱侧凸的艰难历程和新的标记及其用途为脊柱侧凸患者舱与预测发生脊柱侧弯的风险
公开(公告)号：EP3011332A1
公开(公告)日：2016-04-27
申请号：EP14814488.4
申请日：2014-06-17
申请人： CHU Sainte-Justine
IPC分类号： G01N33/48 , A61K31/135 , A61K31/519 , A61K31/713
CPC分类号： G01N33/573 , C12N15/1137 , C12N2310/14 , C12N2320/30 , C12Q1/42 , C12Q1/485 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Y207/01068 , C12Y301/03048 , G01N33/5047 , G01N33/5091 , G01N33/6893 , G01N2333/912 , G01N2333/91215 , G01N2333/916 , G01N2800/10 , G01N2800/50 , G01N2800/56
摘要： Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1γ tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1γ expression and/or activity.
摘要翻译： 分层患有或具有发展脊柱侧凸（AIS）为诊断或临床上都提供了有用的子类风险的受试者的方法。 分层是基于受试者的PTPμ表达和/或活性和/或表达PIPK1γ和/或活性。 因此，提供了预测，因此开发基于主题的PTPμ表达和/或活动和/或PIPK1γ表达和/或活性的脊柱侧弯的风险的方法; 在有需要的受试者，其包括施用至所述受试者的细胞以有效量酪氨酸磷酸化PIPK1γ的抑制剂的细胞增加GiPCR信令和方法; 到酪氨酸的去磷酸化的PIPK1Y活化剂; 和/或在PIPK1γ表达和/或活性的抑制剂。
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2.发明公开NEW MARKERS FOR SEVERE PROGRESSION OF IDIOPATHIC SCOLIOSIS AND USES THEREOF TO STRATIFY SCOLIOTIC PATIENTS AND PREDICT THE RISK OF DEVELOPING SCOLIOSIS 审中-公开特发性脊柱侧凸的艰难历程和新的标记及其用途为脊柱侧凸患者舱与预测发生脊柱侧弯的风险
公开(公告)号：EP3011332A4
公开(公告)日：2017-04-05
申请号：EP14814488
申请日：2014-06-17
申请人： CHU SAINTE-JUSTINE
IPC分类号： G01N33/68 , A61K31/135 , A61K31/519 , A61K31/713 , C12Q1/42 , C12Q1/48 , G01N33/50
CPC分类号： G01N33/573 , C12N15/1137 , C12N2310/14 , C12N2320/30 , C12Q1/42 , C12Q1/485 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Y207/01068 , C12Y301/03048 , G01N33/5047 , G01N33/5091 , G01N33/6893 , G01N2333/912 , G01N2333/91215 , G01N2333/916 , G01N2800/10 , G01N2800/50 , G01N2800/56
摘要： Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1γ tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1γ expression and/or activity.
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