公开(公告)号：EP3312594A1

公开(公告)日：2018-04-25

申请号：EP17190044.2

申请日：2003-05-19

申请人： Life Technologies Corporation

发明人： King, Howard G. ,  Boege, Steven ,  Young, Eugene F. ,  Oldman, Mark

IPC分类号： G01N21/64 ,  B01L7/00

CPC分类号： G01N21/6428 ,  B01L7/52 ,  B01L2300/1805 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0628 ,  Y10S435/808

摘要： An instrument may include an array of sample wells, a plurality of samples arranged in the array of sample wells, a plurality of light sources, a plurality of detectors, a plurality of lightpipes arranged between the plurality of samples and the plurality of detectors, and a plurality of lightpipes arranges between the plurality of light sources and the plurality of detectors. The samples include a plurality of detectable markers being capable of generating increased emission due to a presence of a target component in the sample. The detectable markers have a respective excitation wavelength range and a respective emission wavelength range. The light sources are capable of emitting a plurality of excitation wavelength ranges toward the plurality of samples to respectively excite the detectable markers. The detectors are capable of detecting an emission wavelength range emitted from the detectable markers.

摘要翻译： 仪器可以包括样品孔阵列，排列在样品孔阵列中的多个样品，多个光源，多个检测器，布置在多个样品和多个检测器之间的多个光导管，以及 多个光导管布置在多个光源和多个检测器之间。 样品包括多个可检测标记物，由于样品中存在目标组分，所述多个可检测标记物能够产生增加的发射。 可检测标记具有各自的激发波长范围和各自的发射波长范围。 光源能够向多个样品发射多个激发波长范围以分别激发可检测标记。 检测器能够检测从可检测标记发射的发射波长范围。

公开(公告)号：EP3035037A1

公开(公告)日：2016-06-22

申请号：EP16150671.2

申请日：2003-05-19

申请人： Life Technologies Corporation

发明人： King, Howard G. ,  Boege, Steven ,  Young, Eugene F. ,  Oldman, Mark

IPC分类号： G01N21/64 ,  B01L7/00

CPC分类号： G01N21/6428 ,  B01L7/52 ,  B01L2300/1805 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0628 ,  Y10S435/808

摘要： An instrument is described that includes an array of sample wells (10), a plurality of samples (12) arranged in the array of sample wells, a light source (16), a plurality of detectors (18), a light dividing device, and a plurality of light pipes (24) arranged between the plurality of detectors and the plurality of samples. The samples include a plurality of detectable markers that are capable of generating increased emission due to a presence of a target component in the sample. The detectable markers have a respective excitation wavelength range and a respective emission wavelength range. The light source is capable of emitting excitation wavelength ranges toward the samples to respectively excite the detectable markers. The detectors are capable of detecting an emission wavelength range emitted from the detectable markers. The light dividing device is configured to divide light from the light source between the sample wells of the array of sample wells.

摘要翻译： 描述了包括样品阱阵列（10），布置在样品阱阵列中的多个样品（12），光源（16），多个检测器（18），光分离装置， 以及布置在所述多个检测器和所述多个样品之间的多个光管（24）。 样品包括能够由于样品中目标组分的存在而产生增加的发射的多个可检测标记。 可检测标记具有相应的激发波长范围和相应的发射波长范围。 光源能够向样品发射激发波长范围以分别激发可检测标记。 检测器能够检测从可检测标记物发射的发射波长范围。 光分离装置被配置为将来自光源的光分离在样品阱阵列的样品阱之间。

公开(公告)号：EP2674745A1

公开(公告)日：2013-12-18

申请号：EP13184168.6

申请日：2003-05-19

申请人： Life Technologies Corporation

发明人： Boege, Steven ,  Oldman, Mark ,  Young, Eugene

IPC分类号： G01N21/64

CPC分类号： G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6463 ,  G01N2021/6478 ,  G01N2201/0627 ,  G01N2201/0628

摘要： An instrument comprises a reaction region holding assembly (48) including wells for holding a plurality of spaced-apart reaction regions (40) and a light emitting source (10) adapted to direct excitation beams (15) toward the plurality of reaction regions and to simultaneously illuminate two or more of the spaced-apart reaction regions. The light emitting source includes an array of light emitting diode sources that are arranged in groups, wherein different groups of predetermined numbers of light emitting diode sources are configured to emit different excitation frequencies. The instrument further includes a collimating lens system (20) disposed along the path of excitation beams between the light emitting source and the plurality of reaction regions wherein the collimating lens system is capable of collimating the excitation beams emitted from the light emitting source into two or more spaced-apart bundles of collimated excitation beams (25) and wherein the instrument is capable of directing each of two or more bundles of collimated excitation beams toward a respective reaction region of the plurality of reaction regions.

摘要翻译： 仪器包括反应区域保持组件（48），其包括用于保持多个间隔开的反应区域（40）的孔和适于将激发束（15）朝向多个反应区域引导的发光源（10），并且 同时照亮两个或更多个间隔开的反应区域。 发光源包括以组为单位布置的发光二极管源的阵列，其中预定数量的发光二极管源的不同组被配置为发射不同的激发频率。 仪器还包括沿着发光源和多个反应区域之间的激发光束路径设置的准直透镜系统（20），其中准直透镜系统能够将从发光源发射的激发光束准直成两个或 更均匀分布的准直激励束束（25），并且其中仪器能够将两个或更多个准直激励束束中的每一个朝着多个反应区域的相应反应区域引导。

公开(公告)号：EP2564184A1

公开(公告)日：2013-03-06

申请号：EP11754274.6

申请日：2011-04-25

申请人： Jenoptik Polymer Systems GmbH

发明人： FISCHER, Andreas

IPC分类号： G01N21/77

CPC分类号： G01N21/554 ,  G01N2201/0628

摘要： The invention relates to a method and at least one arrangement for detecting biological and/or chemical substances. A light beam or a light bundle generated by a pumped light energy source with an excitation wavelength λ
Α is directed onto a carrier substrate, on which an optical function structure in the form of an organic luminous means is situated, on which in turn the substance(s) to be detected is/are deposited in a suitable form, such that the difference wavelength λ
ΔΑ or X
R produced as a result of absorption and changed diffraction optical properties is captured using a suitable receiver, and an evaluation unit that is coupled thereto is used to detect the substances on the basis of a data comparison system. The organic phosphor is preferably at least one organic distributed feedback laser (DFB laser). The method and a special arrangement can also be used to detect a specific substance using individual laser pixels (2P).

公开(公告)号：EP2124039A1

公开(公告)日：2009-11-25

申请号：EP08425369.9

申请日：2008-05-22

申请人： Centro Ricerche Plast-Optica S.p.A.

发明人： Melpignano, Patrizia ,  Biondo, Viviana ,  Sinesi, Sabino

IPC分类号： G01N21/64

CPC分类号： G01N21/6454 ,  G01N21/0332 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2021/056 ,  G01N2201/0628

摘要： A biochip (1) for the detection of at least one analyte in a biological sample, comprising:
- a transparent substrate (2) provided with a first surface (3) and a second surface (4),
- a first thin film of transparent conductive material (5) positioned on the first surface (3) of the substrate (1),
- a second thin film of transparent conductive material (6) positioned on the second surface (4) of the substrate (2),
- a light source (7) positioned in direct contact with the first thin film of transparent conductive material (5), and
- a microfluidic system (8) positioned in direct contact with the second layer of thin film of transparent conductive material (6), where the microfluidic system (8) is constituted by a material with low thermal resistance.

摘要翻译： 一种用于检测生物样品中至少一种分析物的生物芯片（1），包括： - 设置有第一表面（3）和第二表面（4）的透明基底（2）， - 透明的第一薄膜 位于基板（1）的第一表面（3）上的导电材料（5）， - 位于基板（2）的第二表面（4）上的透明导电材料（6）的第二薄膜， - 光 源极（7）定位成与透明导电材料（5）的第一薄膜直接接触;以及 - 微透镜系统（8），定位成与透明导电材料（6）的第二薄膜层直接接触，其中 微流体系统（8）由热阻低的材料构成。

公开(公告)号：EP2082216A2

公开(公告)日：2009-07-29

申请号：EP07858657.5

申请日：2007-10-24

申请人： Tiama

发明人： LECONTE, Marc

IPC分类号： G01N21/90

CPC分类号： G01N21/90 ,  G01N2021/8832 ,  G01N2201/0628

摘要： The invention relates to an in-line optical method of inspecting transparent or translucent objects (2) running at high speed between a light source (3) and means (4) for taking images of the objects and for analyzing the images taken, so as to detect defects in the objects. According to the invention the method consists: in controlling the single light source (3) so that said source produces in succession two types of illumination for each object running past said source, the first type being a homogenous illumination whereas the second type is formed from alternate dark zones and light zones with a discontinuous spatial variation; in taking images of each running object when each of them is illuminated in succession by the two types of illumination; and in analyzing the images taken with the illuminations of the first and second types for the purpose of detecting high-contrast defects and low-contrast defects respectively.

公开(公告)号：EP1978351A2

公开(公告)日：2008-10-08

申请号：EP08011345.9

申请日：1999-05-17

申请人： Applera Corporation

发明人： Gambini, Michael R. ,  Atwood, John G. ,  Young, Eugene F. ,  Lakatos, Edward J. ,  Cerrone, Anthony L.

IPC分类号： G01N21/64

CPC分类号： G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

摘要： The invention relates to an optical instrument which is particularly suited for DNA PCR monitoring. The instrument comprises a plurality of spaced-apart reaction ingredient containers (1b), a light source (11) adapted to direct an excitation beam (22) toward the plurality of containers (1b), a Fresnel lens (3) disposed along an excitation beam path between the light source (11) and the plurality of containers (1b) and a detector (10) disposed along an excitation beam path and arranged to receive emission beams (26) emitted from the Fresnel lens (3) which is also disposed along an emission beam path between the plurality of containers (1b) and the detector (10).

摘要翻译： 本发明涉及特别适用于DNA PCR监测的光学仪器。 该仪器包括多个间隔开的反应配料容器（1b），适于朝向多个容器（1b）引导激发光束（22）的光源（11），沿激励设置的菲涅耳透镜（3） 光源（11）和多个容器（1b）之间的光束路径以及沿着激发光束路径设置的检测器（10），所述检测器（10）布置成接收从菲涅耳透镜（3）发射的发射光束（26） 沿着多个容器（1b）和检测器（10）之间的发射束路径。

公开(公告)号：EP1672356A1

公开(公告)日：2006-06-21

申请号：EP05257800.2

申请日：2005-12-19

申请人： Agilent Technologies, Inc.

发明人： Helbing, Rene

IPC分类号： G01N21/86 ,  A61B5/00 ,  G01N33/487

CPC分类号： G01N21/77 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B2562/0295 ,  G01N2201/0628

摘要： A sensor (30), such as a lateral flow sensor, which includes a chemical layer (32) and a detector (36) on a flexible substrate (40). An optical signal is produced in response to an analyte (34) placed on the chemical layer. The detector detects the signal, to thereby detect the presence, absence or concentration of the analyte. The detector is on the substrate. The chemical layer and the substrate are laminated together, to thereby form an integrated sensor. The sensor can include a light source (42). The light source can be on the substrate, or on an opposite side of the chemical layer than the detector.

摘要翻译： 在柔性基板（40）上包括化学层（32）和检测器（36）的传感器（30），诸如横向流量传感器。 响应于放置在化学层上的分析物（34）产生光学信号。 检测器检测信号，从而检测分析物的存在，不存在或浓度。 检测器位于基板上。 将化学层和基板层叠在一起，从而形成集成的传感器。 传感器可以包括光源（42）。 光源可以在基板上，或者在化学层的与检测器相反的一侧上。

公开(公告)号：EP1336089A1

公开(公告)日：2003-08-20

申请号：EP01974483.8

申请日：2001-10-10

申请人： IMPERIAL COLLEGE OF SCIENCE,TECHNOLOGY & MEDICINE

发明人： BRADLEY, Donal ,  DE MELLO, John ,  DE MELLO, Andrew

IPC分类号： G01N21/03 ,  B81B1/00 ,  B01J19/00

CPC分类号： G01N21/6454 ,  G01N21/05 ,  G01N21/253 ,  G01N21/31 ,  G01N2021/0346 ,  G01N2021/6482 ,  G01N2201/0628

摘要： A microfabricated detection system, comprising: a substrate chip; a chamber defined by the substrate chip to which a fluid sample is in use delivered; and at least one detector comprising at least one light-emitting diode including an organic semiconductor element for emitting light into the chamber and at least one photocell including an organic semiconductor element for receiving light from the chamber.

公开(公告)号：EP1171764A1

公开(公告)日：2002-01-16

申请号：EP00990188.5

申请日：2000-11-21

申请人： Iowa State University Research Foundation, Inc. ,  The Regents of The University of Michigan Technology Management Wolverine Tower Office

发明人： AYLOTT, Jonathan W. ,  CHEN-ESTERLIT, Zoe ,  FRIEDL, Jon, H. ,  KOPELMAN, Raoul ,  SAVVATEEV, Vadim, N. ,  SHINAR, Joseph

IPC分类号： G01N21/64

CPC分类号： G01N21/66 ,  G01N21/7703 ,  G01N2201/0628

摘要： Optical sensor, probe and array devices for detecting chemical, biological, and physical analytes. The devices include an analyte-sensitive layer (74) optically coupled to a thin film electroluminescent layer (70) which activates the analyte-sensitive layer to provide an optical response.