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    METHOD AND DEVICE FOR DIAGNOSING CHRONIC FATIGUE SYNDROME (CFS) BY USING NEAR INFRARED SPECTRUM
    4.
    发明公开
    METHOD AND DEVICE FOR DIAGNOSING CHRONIC FATIGUE SYNDROME (CFS) BY USING NEAR INFRARED SPECTRUM 审中-公开
    方法和设备诊断CFS（慢性疲劳综合征）使用所述近红外光谱

    公开(公告)号：EP1882927A1

    公开(公告)日：2008-01-30

    申请号：EP06732587.8

    申请日：2006-05-15

    申请人： Fatique Science Laboratory Inc. ,  OSAKA UNIVERSITY ,  Kuratsune, Hirohiko

    发明人： SAKUDO, Akikazu ,  IKUTA, Kazuyoshi

    IPC分类号： G01N21/35 ,  A61B10/00 ,  G01N33/483

    CPC分类号： A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  G01N21/359 ,  G01N2201/129 ,  G01N2800/306

    摘要： The present invention provides a method and device of quantitatively or qualitatively examining and diagnosing chronic fatigue syndrome (CFS) by: irradiating a sample derived from an examinee or other animal with light having a wavelength in a range of 400 nm to 2500 nm or a wavelength in part of the range; detecting reflected light, transmitted light, or transmitted and reflected light to obtain an absorption spectral data; and analyzing absorbance at all measurement wavelengths or at specific wavelengths in the absorption spectral data by using an analytical model prepared beforehand.

    摘要翻译： 本发明提供了定量的方法和设备或定性检查和通过诊断慢性疲劳综合症（CFS）：照射从受检或其他动物来源的具有波长的光的范围为400nm至2500nm或波长的样品 在该范围的一部分; 检测反射的光，反式mitted光，或反式mitted和反射光以获得吸收光谱数据; 并且通过使用预先准备的分析模型中的所有波长或在吸收光谱数据的特定波长进行分析的吸光度测定。

    NOVEL POLYPEPTIDE AND THE USE THEREOF
    5.
    发明公开
    NOVEL POLYPEPTIDE AND THE USE THEREOF 有权
    除了维多利亚之外的多聚物

    公开(公告)号：EP1829969A1

    公开(公告)日：2007-09-05

    申请号：EP05822348.8

    申请日：2005-12-22

    申请人： Japan as represented by president of National Cardiovascular Center ,  Takeda Pharmaceutical Company Limited

    发明人： KANGAWA, Kenji ,  MORI, Kenji ,  MIYAZATO, Mikiya ,  KOJIMA, Masayasu

    IPC分类号： C12N15/09 ,  A01K67/027 ,  A61K31/711 ,  C12N5/10 ,  A61K39/395 ,  A61K48/00 ,  A61P3/04

    CPC分类号： G01N33/9406 ,  A01K2217/05 ,  A01K2227/10 ,  A61K38/17 ,  C07K14/47 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/046 ,  G01N2800/306 ,  G01N2800/362 ,  G01N2800/367

    摘要： The present invention provides a variety of useful polypeptides. In particular, a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, its amide, or a salt thereof can be used as an agent for preventing/treating hypotension; an agent for preventing/treating obesity, hyperphagia, etc.; an agent for preventing/treating lethargy, time-zone change syndrome (jet lag), etc.; an agent for preventing/treating sterility, etc. A compound or its salt that promotes the activity of a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by any of SEQ ID NOS: 7 to 12 and 37 to 42, its partial peptide, or a salt thereof is useful as an agent for preventing/treating, e.g., menopausal symptoms or hyperthyroidism. A compound or its salt that inhibits the activity of said polypeptide is useful as an agent for preventing/treating, e.g., sterility or hypothyroidism.

    摘要翻译： 本发明提供了多种有用的多肽。 特别地，可以使用包含与SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3所示的氨基酸序列相同或基本上相同的氨基酸序列的多肽，其酰胺或其盐 作为预防/治疗低血压的药物; 用于预防/治疗肥胖症，食欲过盛等的药剂; 预防/治疗嗜睡，时区变化综合征（时差）等的药剂; 用于预防/治疗不育的药剂等。一种促进包含与SEQ ID NO：7至12和37中任一项所示的氨基酸序列相同或基本上相同的氨基酸序列的多肽的活性的化合物或其盐 至42，其部分肽或其盐可用作预防/治疗例如绝经症状或甲状腺功能亢进的药剂。 抑制所述多肽的活性的化合物或其盐可用作预防/治疗例如不育或甲状腺功能减退的药剂。

    Method for diagnosing and treating chronic fatigue syndrome
    6.
    发明公开
    Method for diagnosing and treating chronic fatigue syndrome 审中-公开
    Verfahren zur Diagnose und Behandlung des chronischenErschöpfungssyndroms

    公开(公告)号：EP2687852A1

    公开(公告)日：2014-01-22

    申请号：EP12382283.5

    申请日：2012-07-17

    申请人： Laboratorios del. Dr. Esteve, S.A. ,  Fundació Privada Institut de Recerca de la SIDA-Caixa

    发明人： Cabrera Navarro, Cecilia ,  Curriu Marti, Marta ,  Massanella Luna, Marta ,  Carrillo Molina, Jorge ,  Blanco Arbues, Julian Miguel

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2333/70596 ,  G01N2800/306 ,  G01N2800/50

    摘要： The present invention relates to a method for diagnosing CFS or a predisposition thereto in vitro which comprises determining the levels of CD25, CD69, NKp46 and CD57 biomarkers in CD56+CD16+ NK cells and comparing with a reference value wherein increased levels of said markers is indicative the subject suffers or is predisposed to suffering CFS. Likewise the invention relates to a kit comprising reagents for assaying the levels of CD25, CD69, NKp46 and CD57 in CD56+CD16+ NK cells and to the use of said kit for the diagnosis of CFS or of a predisposition thereto. In addition, the invention relates to a reagent for inhibiting the expression or activity of at least one biomarker selected from the group consisting of CD69, NKp46 and CD5 or to a reagent for inducing the expression or activity of at least one biomarker selected from CD25, CD57, CD56 and Ki67 for use in the treatment or prevention of CFS in a subject in need thereof. Finally the invention relates to a kit comprising a reagent for inhibiting or inducing a biomarker of the invention and to the use of said kit for the treatment or prevention of CFS.

    摘要翻译： 本发明涉及用于诊断体外CFS或其易感性的方法，其包括测定CD56 + CD16 + NK细胞中CD25，CD69，NKp46和CD57生物标志物的水平，并与参考值进行比较，其中所述标记物的增加水平是指示性的 受试者遭受或倾向于患有CFS。 同样，本发明涉及包含用于测定CD56 + CD16 + NK细胞中CD25，CD69，NKp46和CD57水平的试剂的试剂盒，以及所述试剂盒用于诊断CFS或其易感性的用途。 此外，本发明涉及用于抑制至少一种选自CD69，NKp46和CD5的生物标志物的表达或活性的试剂，或涉及用于诱导至少一种选自CD25， CD57，CD56和Ki67，用于治疗或预防有需要的受试者中的CFS。 最后，本发明涉及包含用于抑制或诱导本发明的生物标志物的试剂以及所述试剂盒用于治疗或预防CFS的试剂盒。

    DETECTION OF OVERTRAINING SYNDROME IN AN INDIVIDUAL
    7.
    发明公开
    DETECTION OF OVERTRAINING SYNDROME IN AN INDIVIDUAL 有权
    检测一个人关于培训综合征

    公开(公告)号：EP2548026A1

    公开(公告)日：2013-01-23

    申请号：EP11714085.5

    申请日：2011-03-15

    申请人： Knight Scientific Limited

    发明人： KNIGHT, Jan

    IPC分类号： G01N33/569

    CPC分类号： G01N33/56972 ,  G01N2800/306

    摘要： The onset of or the existence of overtraining syndrome in an individual is detected by a method which comprises a) contacting leucocytes in, or obtained from, a blood sample provided by the individual with a luminescence reagent which emits light on reaction with an oxidant; b) adding an activator to the mixture of leucocytes and the luminescence reagent; c) continuously monitoring and/or measuring light emitted by the luminescence reagent over a predetermined time period commencing before and ending after the addition of the activator; and d) assessing the light emission. The individual may be a human, for example an elite athlete, or a non- human mammal, for example a racehorse. A diagnostic kit, for carrying out the method, comprising a luminescence reagent which emits light on reaction with an oxidant, an activator and a library of standard signature light emission curves is also disclosed.

    NOVEL POLYPEPTIDE AND THE USE THEREOF
    8.
    发明公开
    NOVEL POLYPEPTIDE AND THE USE THEREOF 有权
    新的多肽及其用途

    公开(公告)号：EP1829969A4

    公开(公告)日：2008-07-30

    申请号：EP05822348

    申请日：2005-12-22

    申请人： JAPAN GOVERNMENT ,  TAKEDA PHARMACEUTICAL

    发明人： KANGAWA KENJI ,  MORI KENJI ,  MIYAZATO MIKIYA ,  KOJIMA MASAYASU

    IPC分类号： C12N15/09 ,  A01K67/027 ,  A61K31/711 ,  A61K39/395 ,  A61K48/00 ,  A61P3/04 ,  C12N5/10

    CPC分类号： G01N33/9406 ,  A01K2217/05 ,  A01K2227/10 ,  A61K38/17 ,  C07K14/47 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/046 ,  G01N2800/306 ,  G01N2800/362 ,  G01N2800/367

    摘要： It is intended to provide a variety of useful polypeptides. Particularly, a polypeptide comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, an amide form thereof or a salt thereof can be used as a preventive/therapeutic agent for low blood pressure, a preventive/therapeutic agent for obesity, hyperphagia or the like, a preventive/therapeutic agent for lethargy, time-zone change syndrome (jet lag) or the like, a preventive/therapeutic agent for infertility and the like. A compound that promotes the activity of a polypeptide comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by any of SEQ ID NOS: 7 to 12 and 37 to 42, a partial peptide of the polypeptide or a salt of the polypeptide, or a salt of the compound is useful as a preventive/therapeutic agent for, for example, climacteric disorder or hyperthyroidism. A compound that inhibits the activity of the polypeptide or a salt of the compound is useful, for example, as a preventive/therapeutic agent for infertility or thyroid insufficiency.

    Sensory receptors for chronic fatigue and pain and uses thereof
    10.
    发明公开
    Sensory receptors for chronic fatigue and pain and uses thereof 审中-公开
    感觉感受器慢性疲劳和疼痛及其用途

    公开(公告)号：EP2853897A1

    公开(公告)日：2015-04-01

    申请号：EP14198032.6

    申请日：2009-05-07

    申请人： University Of Utah Research Foundation

    发明人： Light, Alan R. ,  Light, Kathleen C. ,  Hugen, Ronald W. ,  White, Andrea T.

    IPC分类号： G01N33/68 ,  A61K31/472

    CPC分类号： A61K31/472 ,  C12Q1/6883 ,  G01N33/6887 ,  G01N2500/10 ,  G01N2800/306 ,  G01N2800/52

    摘要： The present invention relates generally to the fields of pathological muscle pain/fatigue conditions. More specifically, the invention concerns a method for diagnosing pathological muscle pain/fatigue conditions. The invention also concerns a method for of determining responsiveness of a pathological muscle/fatigue condition to treatment with a pharmaceutical agent, as well as a method for screening the efficacy of a pharmaceutical agent for the ability to treat pathological muscle/fatigue conditions.

    摘要翻译： 本发明涉及基因集会的病理肌肉疼痛/疲劳条件的字段。 更具体地，本发明涉及用于诊断病理肌肉疼痛/疲劳条件的方法。 因此，本发明涉及一种用于病理肌肉/疲劳条件确定性对治疗的反应，用药物的采矿的方法，以及用于筛选药物的功效为用于治疗病理性肌/疲劳条件的能力的方法。