公开(公告)号：EP4435429A2

公开(公告)日：2024-09-25

申请号：EP24184897.7

申请日：2016-07-29

申请人： Honeywell International Inc.

发明人： XIE, Guangli ,  CHEN, Bo ,  WU, Zhanghua ,  GONG, Yaofu

IPC分类号： G01N33/00

CPC分类号： G01N27/66 ,  G01N30/64 ,  G01N30/8665 ,  G01N2030/64220130101 ,  G01N33/0006

摘要： A method of detecting gas with a photoionization detector, PID, system (1, 100), comprising: determining and storing, by a controller (2, 102), a zero level of a photoionization detector (4, 104, 106, 108, 112, 116), using ambient air flowed from surrounding environment past a detector electrode (108) of the photoionization detector (4, 104, 106, 108, 112, 116), wherein the stored zero level is based on an ambient temperature; sensing the ambient temperature; adapting the stored zero level algorithmically based on a change sensed in the ambient temperature; sampling, by the controller (2, 102), an output of the detector electrode (108) of the photoionization detector (4, 104, 106, 108, 112, 116) when an ultraviolet lamp (106) is in a turned ON state; and comparing the sampled output of the detector electrode (108) to the stored zero level to determine if a threshold concentration of a gas is present.

公开(公告)号：EP3724654B1

公开(公告)日：2024-04-24

申请号：EP18889382.0

申请日：2018-12-13

IPC分类号： G01N30/88

CPC分类号： G01N30/72 ,  G01N30/8665 ,  G01N2030/881320130101 ,  G16C20/20 ,  H01J49/0036

公开(公告)号：EP3355054A1

公开(公告)日：2018-08-01

申请号：EP16847978.0

申请日：2016-08-30

申请人： Guangdong Lianjie Biotechnology Co., Ltd.

发明人： ZHU, Janshon

IPC分类号： G01N30/88

CPC分类号： H01J49/0009 ,  G01N30/06 ,  G01N30/36 ,  G01N30/7233 ,  G01N30/8665 ,  G01N30/88 ,  G01N2030/8822

摘要： Present invention discloses a pseudo internal standard method, device and application for mass spectrometry quantitative analysis. The method comprises steps: taking a standard, and formulating same into standard solutions with different concentrations by using a blank substrate of a sample to be tested, and then taking the same standard, and formulating same into internal standard solutions with one to several concentrations by using the blank substrate of the sample to be tested; processing the standard solutions and the internal standard solutions with different concentrations, through a sample processing steps, into standard samples and internal standard samples; successively injecting the standard sample and the internal standard sample into a chromatography-mass spectrometry system to be analyzed and measured; plotting a ratio of peak areas of the standard sample and the internal standard sample against the concentrations of the standard samples to establish a calibration curve of pseudo internal standard method quantification; and processing the unknown sample by the same sample processing steps then following the same steps as standard sample analysis to inject the sample to be detected and the internal standard into the chromatography-mass spectrometry system for analysis and measurement, the peak area ratio of the sample over the internal standard is then compared with the calibration curve to determine the concentration of the unknown sample.

公开(公告)号：EP3143394A1

公开(公告)日：2017-03-22

申请号：EP15722209.2

申请日：2015-05-13

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften

发明人： KULAK, Nils A. ,  NAGARAJ, Nagarjuna ,  SCHELTEMA, Richard ,  MANN, Matthias

IPC分类号： G01N30/86 ,  G01N30/72 ,  G01N30/04 ,  G01N30/34

CPC分类号： G01N30/8665 ,  G01N30/04 ,  G01N30/34 ,  G01N30/7266 ,  G01N2030/042

摘要： The present invention relates to a method of monitoring performance of a liquid chromatography-mass spectrometry (LC-MS) system, comprising the steps of: (a) performing LC with a first buffer, said first buffer comprising a defined concentration of a first compound, said performing comprising a step of eluting; (b) subjecting the eluate of said LC to electrospray ionization; and (c) determining the amount of said first compound in said eluate by means of MS, thereby monitoring said performance; wherein said first compound (i) has either no affinity or negligible affinity to the chromatographic matrix; and (ii) is detectable by MS.

摘要翻译： 本发明涉及监测液相色谱 - 质谱（LC-MS）系统的性能的方法，其包括以下步骤：（a）用第一缓冲液进行LC，所述第一缓冲液包含限定浓度的第一化合物 所述执行包括洗脱步骤; （b）使所述LC的洗脱液经受电喷雾电离; 和（c）借助MS确定所述洗脱液中所述第一化合物的量，由此监测所述性能; 其中所述第一化合物（i）对色谱基质不具有亲和性或可忽略的亲和性; 和（ii）可由MS检测。

公开(公告)号：EP1718962B1

公开(公告)日：2016-04-13

申请号：EP05722891.8

申请日：2005-02-11

申请人： Waters Technologies Corporation

发明人： GORENSTEIN, Marc, V. ,  LI, Guo-Zhong

IPC分类号： G01N30/72 ,  G01N30/86

CPC分类号： G01N30/8665 ,  G01N30/7233 ,  G01N30/8679 ,  G01N30/8693 ,  H01J49/0036

公开(公告)号：EP2684040A4

公开(公告)日：2014-09-03

申请号：EP12757668

申请日：2012-03-12

申请人： UNIV BRIGHAM YOUNG

发明人： LEE MILTON L ,  XIE XIAOFENG ,  MURRAY JACOLIN A ,  CONTRERAS JESSE A ,  TRUONG TAI VAN ,  TOLLEY DENNIS H

IPC分类号： G01N30/72 ,  G01N30/04 ,  G01N33/00

CPC分类号： G01N30/8665 ,  G01N30/7206 ,  G01N33/0006 ,  G01N2001/2893

摘要： A system for providing standard mixtures of volatile and semi-volatile organic compounds for simultaneous CC and MS calibration in a calibration vial, wherein calibration mixtures are prepared by diluting calibration analytes in granular PDMS such that most of the analytes are in the PDMS phase and the sample can then be taken from the analytes in the headspace vapor in the calibration vial, wherein a reliable calibration sample can be taken from the calibration vial because the analytes in the PDMS phase and the headspace vapor are in thermodynamic equilibrium, and wherein the method provides solvent-less sampling, long-time stability, ease of use, is quantifiable, and related to temperature.

公开(公告)号：EP2235523A4

公开(公告)日：2011-02-23

申请号：EP09702007

申请日：2009-01-15

申请人： METABOLON INC

发明人： MILGRAM K ERIC ,  BARRETT THOMAS ,  EVANS ANNE M

IPC分类号： G01N30/72 ,  G01N30/86 ,  G01N30/88

CPC分类号： G01N30/8675 ,  G01N30/7233 ,  G01N30/8651 ,  G01N30/8665 ,  G06F19/703 ,  H01J49/0036

摘要： Systems, methods, and computer-readable media for determining composition of chemical constituents in a complex mixture are disclosed. According to one aspect, a method for determining composition of chemical constituents in a complex mixture includes generating, using a separation tool and a mass spectrometer, separation and mass spectrometry data of a sample, wherein the separation data includes peak information and wherein the mass spectrometry data includes primary and secondary mass spectrometry data. The analysis results, including the generated separation and mass spectrometry data, are collected and stored. A chemical constituent of the sample is determined by comparing the analysis results to a library of information indicating characteristics of chemical entities, where the comparison is based on the separation and mass spectrometry information. The library of information includes data generated by the separation tool and mass spectrometer, and also includes separation and mass spectrometry data for both identified and unidentified chemical entities. An indication of the chemical constituent of the sample is made available in human-accessible form.

公开(公告)号：EP1384248B1

公开(公告)日：2005-10-19

申请号：EP01974972.0

申请日：2001-08-03

申请人： Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNO

发明人： VOGELS, Jacibus, Thomas, Wilhelmus, Elisabeth ,  WULFERT, Florian ,  VAN DER GREEF, Jan ,  TAS, Albert

IPC分类号： H01J49/04

CPC分类号： G01N30/8665 ,  G01N30/8624 ,  G01N30/8641 ,  G01N30/8662 ,  G01N30/8686 ,  H01J49/0036

公开(公告)号：EP1471351A1

公开(公告)日：2004-10-27

申请号：EP04007073.2

申请日：2004-03-24

申请人： ETHYL CORPORATION

发明人： Fedorova, Galina, V.

IPC分类号： G01N30/86 ,  G01N33/28 ,  G01N30/02

CPC分类号： G01N30/8665 ,  G01N30/02 ,  G01N30/461 ,  G01N30/74 ,  G01N30/78 ,  G01N33/28 ,  G01N2030/047 ,  G01N2030/8854 ,  Y10T436/21 ,  B01D15/34

摘要： The identity and concentration of an additive package in a liquid hydrocarbon matrix may be measured by an analytical liquid chromatography analysis. A sample is prepared and passed through a separation means and at least one detector means, and signals are generated that permit identification and quantitative measurement of additives in a liquid hydrocarbon matrix.

摘要翻译： 通过在分析系统输送液体烃基质样品具有分离器（一个或多个）和检测器（一个或多个），所以确实信号（S）由分析系统产生的添加剂包或者其混合物同一性确定性开采在液态烃中的矩阵。的标准 在烃矩阵公知的添加剂包进行比较以从样品到确定性矿的添加剂包在样品中的身份的信号。 因此独立claimsoft包括用于燃料包括从燃料样品在烃矩阵从已知的添加剂包的标准输送燃料样品的分析系统和比较信号到信号确定性矿的确定性挖掘横牵引的方法中的 燃料样本中的所有添加剂包的身份和/或浓度。

公开(公告)号：EP1070142A1

公开(公告)日：2001-01-24

申请号：EP99909649.8

申请日：1999-02-25

申请人： MOLECULAR DYNAMICS, INC.

发明人： MANSFIELD, Elaine, S. ,  ZHAO, Lian-She ,  VAINER, Marina ,  KAUTZER, Curtis R.

IPC分类号： C12Q1/68 ,  C12P19/34 ,  B01D15/08 ,  G01N30/00

CPC分类号： G01N30/8665 ,  C12N15/101 ,  C12Q1/68 ,  C12Q1/6827 ,  G01N27/44717 ,  G01N30/8631 ,  G01N30/8634 ,  G01N30/8658 ,  G01N2201/129

摘要： A method (200) for performing separation assays of biochemical samples includes computing a quality metric (210) based on peak data produced during the separation run. The quality metric is the basis for selecting a subsequent step in the assay, including whether to re-run the separation when the quality metric indicates a low quality separation run. In a preferred embodiment, the quality metric is computed based on a peak resolution metric indicative of the peak resolution of the sample peaks in the data and a signal-to-noise ratio of the data. When a co-migrating standard is included in the separation run, the quality metric is further based on the degree of migration linearity of the reference peaks produced by the standard. The method was reduced to practice in separations to size and sort DNA fragments in high-throughput capillary array electrophoresis separations.