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    CONTROLLED ALIGNMENT OF NANOBARCODES ENCODING SPECIFIC INFORMATION FOR SCANNING PROBE MICROSCOPY (SPM) READING
    1.
    发明授权
    CONTROLLED ALIGNMENT OF NANOBARCODES ENCODING SPECIFIC INFORMATION FOR SCANNING PROBE MICROSCOPY (SPM) READING 有权
    纳米条形码的排列受控对探针显微分析具体所包含的信息GRID

    公开(公告)号：EP1543152B1

    公开(公告)日：2011-03-09

    申请号：EP03752088.9

    申请日：2003-09-05

    申请人： Intel Corporation

    发明人： CHAN, Selena ,  SU, Xing ,  YAMAKAWA, Mineo

    IPC分类号： C12Q1/68 ,  G01N33/543

    CPC分类号： C12Q1/6816 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  Y10S977/702 ,  Y10S977/704 ,  Y10S977/705 ,  Y10S977/728 ,  Y10S977/729 ,  Y10S977/734 ,  Y10S977/742 ,  Y10S977/773 ,  Y10S977/774 ,  Y10S977/924 ,  C12Q2565/601 ,  C12Q2563/185

    摘要： The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nanobarcodes may be allowed to bind to one or more target molecules. After binding and separation from unbound coded probes, the bound coded probes may be aligned on a surface and analyzed by scanning probe microscopy. The nanobarcodes may be any molecule or complex that is distinguishable by SPM, such as carbon nanotubes, fullerenes, submicrometer metallic barcodes, nanoparticles or quantum dots. Where the probes are oligonucleotides, adjacent coded probes hybridized to a target nucleic acid may be ligated together before alignment and SPM analysis. Compositions comprising coded probes are also disclosed herein. Systems for biomolecule analysis may comprise an SPM instrument and at least one coded probe attached to a surface.

    摘要翻译： 所述方法，装置和组合物在光盘游离缺失关注的生物分子如，：核酸或蛋白质等的检测，鉴定和/或测序。 在本发明的某些实施方案中，包括连接到一个或多个纳米条形码探针分子编码探针可以结合至一个或多个目标分子。 与未结合的编码探针的结合和分离后，将结合的编码探针可以在表面上对齐，并且通过扫描探针显微镜分析。 纳米条形码可以是任何分子或复合物确实是由SPM区分：例如碳纳米管，富勒烯，亚微米金属条形码，纳米颗粒或量子点。 其中探针是寡核苷酸，相邻的编码探针杂交到靶核酸之前对准和扫描探针显微镜（SPM）分析可以连接在一起。 组合物，包含编码探针因此光盘游离缺失。 用于生物分子分析系统可以包括SPM仪器和附着于表面的至少一个已编码探针的。

    Cremophor free epothilone particles coated with protein for treating cancer
    3.
    发明公开
    Cremophor free epothilone particles coated with protein for treating cancer 审中-公开
    无乳浮蛋白涂Epothilonepartikel治疗癌症

    公开(公告)号：EP2014286A3

    公开(公告)日：2009-03-18

    申请号：EP08016544.2

    申请日：2001-05-18

    申请人： Abraxis BioScience, LLC

    发明人： Desai, Neil P. ,  Soon-Shiong, Patrick

    IPC分类号： A61K31/337 ,  A61K9/51 ,  A61K9/14 ,  A61P35/00 ,  A61K31/427

    CPC分类号： A61K31/00 ,  A23L33/40 ,  A61K9/0026 ,  A61K9/1075 ,  A61K9/5052 ,  A61K9/5169 ,  A61K31/337 ,  A61K31/425 ,  B82Y5/00 ,  Y10S977/729 ,  Y10S977/773 ,  Y10S977/775 ,  Y10S977/896 ,  Y10S977/906 ,  Y10S977/915

    摘要： In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful election of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within.

    Cremophor free epothilone particles coated with protein for treating cancer
    8.
    发明公开
    Cremophor free epothilone particles coated with protein for treating cancer 审中-公开
    Cremophor freie mit蛋白质beschichteten Epothilonepartikel zur Behandlung von Krebs

    公开(公告)号：EP2014286A2

    公开(公告)日：2009-01-14

    申请号：EP08016544.2

    申请日：2001-05-18

    申请人： Abraxis BioScience, Inc.

    发明人： Desai, Neil P. ,  Soon-Shiong, Patrick

    IPC分类号： A61K31/337 ,  A61K9/51 ,  A61K9/14 ,  A61P35/00 ,  A61K31/427

    CPC分类号： A61K31/00 ,  A23L33/40 ,  A61K9/0026 ,  A61K9/1075 ,  A61K9/5052 ,  A61K9/5169 ,  A61K31/337 ,  A61K31/425 ,  B82Y5/00 ,  Y10S977/729 ,  Y10S977/773 ,  Y10S977/775 ,  Y10S977/896 ,  Y10S977/906 ,  Y10S977/915

    摘要： In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful election of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within.

    摘要翻译： 根据本发明，提供了用于体内递送基本上不溶于水的药理学活性剂（例如抗癌药物紫杉醇）的组合物和方法，其中药理活性剂以涂覆有悬浮颗粒的悬浮颗粒的形式递送 蛋白质（其作为稳定剂）。 特别地，生物相容性分散介质中的蛋白质和药理学活性剂在没有任何常规表面活性剂的情况下进行高剪切，并且在没有用于颗粒的任何聚合物芯材料的情况下进行。 该方法产生直径小于约1微米的颗粒。 使用特定的组成和制备条件（例如，向有机相中加入极性溶剂）以及仔细选择合适的有机相和相分数使得能够可重复地生产直径小于200nm的异常小的纳米颗粒， 可以无菌过滤。 根据本发明制备的颗粒系统可以转化成可再分散的干粉，其包含用蛋白质包被的水不溶性药物的纳米颗粒，以及结合有药理学分子的游离蛋白质。 这导致独特的递送系统，其中药理活性剂的一部分容易生物利用（以与蛋白质结合的分子的形式），并且部分药剂存在于其内。