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36 条记录 (耗时 0.011 秒)

    2- or 3-dimensional geometric structures
    1.
    发明公开
    2- or 3-dimensional geometric structures 失效
    2- ODER 3-DIMENSIONALE GEOMETRISCHE STRUKTUR AUSPEPTIDNUKLEINSÄUREN

    公开(公告)号：EP0881228A2

    公开(公告)日：1998-12-02

    申请号：EP98109492.3

    申请日：1998-05-26

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： Batz, Hans-Geor, Dr. ,  Koch, Troels, Dr. ,  Hansen, Henrik Frydenlund

    IPC分类号： C07H21/00 ,  C07K14/00

    CPC分类号： B82Y30/00 ,  C07H21/00 ,  C07K14/003 ,  Y10S977/704 ,  Y10S977/728 ,  Y10S977/734 ,  Y10S977/753 ,  Y10S977/792 ,  Y10S977/80 ,  Y10S977/906

    摘要： Nucleic acid analogues provide a particularly useful tool for the preparation of complex polymeric structures of defined geometry because they are relatively stable to reaction conditions for the preparation of such structures and provide the opportunity to introduce reactive groups which would not be possible with usual nucleic acids. These supramolecular structures can be used to form fine networks in nanometer size, for the preparation of e.g. computer chips, new materials/polymers with conductivity and/or insulator properties, and robot arms in nanometer scale.

    摘要翻译： 核酸类似物为制备具有规定几何形状的复合聚合物结构提供了特别有用的工具，因为它们对制备这种结构的反应条件相对稳定，并且提供引入与常规核酸不可能的反应性基团的机会。 这些超分子结构可用于形成纳米尺寸的精细网络，用于制备例如。 计算机芯片，具有导电性和/或绝缘体性能的新材料/聚合物，以及纳米尺度的机器人手臂。

    FLUORESCENT CARBON NANOPARTICLES
    3.
    发明公开
    FLUORESCENT CARBON NANOPARTICLES 审中-公开
    荧光碳纳米粒子

    公开(公告)号：EP1945736A2

    公开(公告)日：2008-07-23

    申请号：EP06827020.6

    申请日：2006-10-27

    申请人： Clemson Universtiy

    发明人： SUN, Ya-Ping

    IPC分类号： C09K11/65 ,  G01N33/551

    CPC分类号： C09K11/025 ,  C01B32/05 ,  C09K11/65 ,  G01N33/587 ,  Y10S977/70 ,  Y10S977/702 ,  Y10S977/703 ,  Y10S977/704 ,  Y10S977/705 ,  Y10S977/773 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： Disclosed are photoluminescent particles. The particles include a core nano-sized particle of carbon and a passivation agent bound to the surface of the nanoparticle. The passivation agent can be, for instance, a polymeric material. The passivation agent can also be derivatized for particular applications. For example, the photoluminescent carbon nanoparticles can be derivatized to recognize and bind to a target material, for instance a biologically active material, a pollutant, or a surface receptor on a tissue or cell surface, such as in a tagging or staining protocol.

    摘要翻译： 公开的是光致发光粒子。 颗粒包括核心纳米尺寸的碳颗粒和结合到纳米颗粒表面的钝化剂。 钝化剂可以是例如聚合物材料。 钝化剂也可以衍生用于特定的应用。 例如，光致发光碳纳米颗粒可被衍生化以识别并结合目标材料，例如生物活性材料，污染物或组织或细胞表面上的表面受体，例如在标签或染色方案中。

    CONTROLLED ALIGMENT OF NANO-BARCODES ENCODING SPECIFIC INFORMATION FOR SCANNING PROBE MICROSCOPY (SPM) READING
    5.
    发明公开
    CONTROLLED ALIGMENT OF NANO-BARCODES ENCODING SPECIFIC INFORMATION FOR SCANNING PROBE MICROSCOPY (SPM) READING 审中-公开
    用于测量的扫描探针显微镜（SPM）CODING NANO-条形码的特定信息的排列受控的

    公开(公告)号：EP1546983A2

    公开(公告)日：2005-06-29

    申请号：EP03770369.1

    申请日：2003-09-22

    申请人： INTEL CORPORATION

    发明人： CHAN, Selena ,  SU, Xing ,  YAMAKAWA, Mineo

    IPC分类号： G06F19/00

    CPC分类号： C12Q1/6816 ,  Y10S977/704 ,  Y10S977/728 ,  Y10S977/734 ,  Y10S977/742 ,  Y10S977/773 ,  Y10S977/774 ,  C12Q2565/601 ,  C12Q2563/155 ,  C12Q2537/143

    摘要： The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nano-barcodes may be allowed to bind to one or more target molecules. After binding and separation from unbound coded probes, the bound coded probes may be aligned on a surface and analyzed by scanning probe microscopy. Where the probes are oligonucleotides, adjacent coded probes hybridized to a target nucleic acid may be ligated together before alignment and SPM analysis. Compositions comprising coded probes are also disclosed herein. Systems for biomolecule analysis may comprise an SPM instrument and at least one coded probe attached to a surface.

    摘要翻译： 所述方法，装置和组合物在光盘游离缺失关注的生物分子如，：核酸或蛋白质等的检测，鉴定和/或测序。 在本发明的某些实施方案中，包括连接到一个或多个纳米条形码探针分子编码探针可以结合至一个或多个目标分子。 与未结合的编码探针的结合和分离后，将结合的编码探针可以在表面上对齐，并且通过扫描探针显微镜分析。 其中探针是寡核苷酸，相邻的编码探针杂交到靶核酸之前对准和SPM分析可以连接在一起。 组合物，包含编码探针因此光盘游离缺失。 用于生物分子分析系统可以包括SPM仪器和附着于表面的至少一个已编码探针的。

    DETECTION OF LIGAND INTERACTION WITH POLYMERIC MATERIAL
    6.
    发明公开
    DETECTION OF LIGAND INTERACTION WITH POLYMERIC MATERIAL 失效
    配体交换线圈与聚合物物料确定

    公开(公告)号：EP0906562A2

    公开(公告)日：1999-04-07

    申请号：EP97932372.0

    申请日：1997-06-20

    申请人： NEW YORK UNIVERSITY

    发明人： MOROZOV, Victor N. ,  MOROZOVA, Tamara Ya

    IPC分类号： G01N33 ,  C12M1 ,  C12N15 ,  C12Q1 ,  G01N3 ,  G01N11

    CPC分类号： G01N33/54353 ,  G01N3/04 ,  G01N11/16 ,  G01N33/54366 ,  Y10S977/704

    摘要： A method and apparatus for measuring ligand binding to DNA or protein uses changes in the mechanical properties of strips of the DNA or protein to detect the formation of ligand complexes. Samples strips are prepared by pouring protein solution onto a glass surface, drying the solution, and causing the protein to be cross-linked; the cross-linked film is scraped off, cut into strips, and mounted in the stress/strain measuring apparatus, which includes force and strain transducers. The sample is held by arms and can be immersed into solutions. The arms are attached to transducers. The apparatus includes a sample holder. The sample films may include end reinforcements and may be pinned or glued to the arms.

    METHOD AND DEVICE FOR DETECTING BIOMOLECULES
    9.
    发明授权
    METHOD AND DEVICE FOR DETECTING BIOMOLECULES 有权
    方法和设备检测生物分子

    公开(公告)号：EP1604042B1

    公开(公告)日：2008-01-02

    申请号：EP04720593.5

    申请日：2004-03-15

    申请人： bioMérieux S.A.

    发明人： MANDRAND, Bernard ,  DUPONT-FILLIARD, Agnès

    IPC分类号： C12Q1/68

    CPC分类号： B82Y5/00 ,  C12Q1/6825 ,  C12Q1/6837 ,  C12Q2563/125 ,  C12Q2565/113 ,  C12Q2565/607 ,  G01N33/5438 ,  Y10S977/70 ,  Y10S977/702 ,  Y10S977/704 ,  Y10S977/705 ,  Y10S977/72

    摘要： The present invention relates to a method for detecting a target biomolecule in a sample comprising a plurality of biomolecules, whereby the target biomolecule is provided with a tag, said tag comprising a catalytic active moiety which catalyses a reaction yielding an insoluble reaction product which precipitates on flexible electrically conductive nanoelectrodes. The precipitation onto said nanoelectrodes causes a change in their electroconductivity which is accessible to electroanalytical methods. The invention relates further to a a biochip comprising a solid support with nanoelectrodes attached thereto and probe molecules bound to all or to a plurality of said nanoelectrodes which may be the same or different, a segment of said probe molecules being able to interact specifically with a segment of the target biomolecules.