摘要:
A controlled release tablet comprising I) a core, containing as essential components a) at least one water-soluble pharmaceutically active substance which is dispersed in a water-insoluble, non-digestible polymeric excipient, and b) a water-insoluble polymeric substance, which is swellable under the influence of water, and II) a coating consisting essentially of an elastic, water-insoluble and semipermeable diffusion film of a polymer, is presented, which shows a release pattern for the active substance(s) in a programmed rate of approximately zero order.
摘要:
A solid pharmaceutical preparation for administration in dosage unit form comprising a therapeutically effective cardiac glycoside, whereby each dosage unit is to comprise a plurality of bodies, each of said bodies having a pharmaceutically inert core and a layer thereon containing the glycoside and a polymer insoluble in gastric juice and soluble in intestinal juice, a process for preparing such preparation and a method of treatment employing the same.
摘要:
Aqueous solutions of certain cationic (meth)acrylic ester copolymers can be used to coat dosage forms to taste- and odor-mask bio-active agents therein. Pellets are highly preferred dosage forms.
摘要:
Pharmacologically-acceptable, solid, particulate, cross- linked, indigestable, fat imbibing, fat retaining polymers which swell in liquid lard, contain less than 100 ppm of residual monomer and have a volume average particle size of 0.05 to 500 microns are useful in controlling obesity in animals on a high fat diet.
摘要:
Polyvinyl alcohol for use as a film coating, a matrix for monolithic device or as a barrier coating for the preparation of controlled release drug delivery systems.