公开(公告)号：EP4450069A3

公开(公告)日：2025-02-12

申请号：EP24184793.8

申请日：2019-11-27

Applicant: Attgeno AB

Inventor： AGVALD, Per Håkan ,  ADDING, Leif Christofer ,  NILSSON, Kristofer Bo Ingemar ,  MINIDIS, Anna Lena Elisabeth ,  MALMBERG, Johan Salman ,  MINIDIS, Alexander Bogdan Emil

IPC: C07C201/04 ,  C07C203/00 ,  A61K31/21 ,  A61K31/047 ,  A61P9/12

Abstract: The present invention relates to a novel process for the synthesis of mono- and bis-nitrosylated propanediols, as well as novel compositions and pharmaceutical formulations comprising said compounds. The process proceeds by reacting a corresponding propanediol that is not nitrosylated with a source of nitrite, optionally in the presence of a suitable acid. Wherein, when the source of nitrite is an organic nitrite, reacting step is performed in a suitable organic solvent, and when the source of nitrite is an inorganic nitrite, the reacting step is performed in a bi-phasic solvent mixture comprising an aqueous phase and a non-aqueous phase. The invention also relates to methods of treating a condition wherein administration of nitric oxide (NO) has a beneficial effect by administering said compounds, compositions or formulations.

公开(公告)号：EP4288413B1

公开(公告)日：2025-01-22

申请号：EP21706850.1

申请日：2021-02-03

Inventor： ALMIRANTE, Nicoletta ,  RONSIN, Gael ,  DIKER, Khalid ,  GORINS, Gilles ,  COUSIN, Jonathan ,  BRUNEAU, Audrey

IPC: C07C405/00 ,  C07C201/02 ,  C07C203/04

公开(公告)号：EP3592727B1

公开(公告)日：2024-04-03

申请号：EP18709001.4

申请日：2018-03-05

Inventor： CHAN, Denise ,  KNAUF, Thomas ,  MÜNNIG, Jürgen

IPC: C07C201/08 ,  C07C201/16 ,  C07C205/06

公开(公告)号：EP4295841A3

公开(公告)日：2024-03-13

申请号：EP23191114.0

申请日：2015-06-05

Applicant: The Scripps Research Institute

Inventor： DONG, Jiajia ,  SHARPLESS, K. Barry ,  KELLY, Jeffery W. ,  BARANCZAK, Aleksandra ,  CHEN, Wentao

IPC: C07C201/00 ,  A61K31/10 ,  A61K31/16 ,  C07K1/00

Abstract: This application describes a compound represented by Formula (I): (I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X 1 is a covalent bond or -CH 2 CH 2 -, X 2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.

公开(公告)号：EP4324558A1

公开(公告)日：2024-02-21

申请号：EP22787881.6

申请日：2022-03-02

Applicant: Organo Corporation

Inventor： NAKAMURA, Shinji ,  SAJIKI, Hironao ,  YAMADA, Tsuyoshi ,  PARK, Kwihwan ,  YAMADA, Yutaro

IPC: B01J35/04 ,  B01J35/10 ,  C07B37/04 ,  C07C22/08 ,  C07C201/14 ,  C07C205/06 ,  C07C253/30 ,  C07C255/50 ,  C07C17/26 ,  C07B61/00 ,  C08J5/20 ,  B01J41/05 ,  B01J41/14 ,  B01J47/12 ,  B01J31/08

Abstract: The purpose of the present invention is to provide: an ion exchanger which shows small shrinkage upon the contact with an organic solvent in a water-wetted state; and a method for producing the ion exchanger. Provided is an ion exchanger which is composed of a polymer chain represented by general formula (1)

(wherein R 1 represents an alkyl group of 4 to 22 carbon atoms which may be substituted; or a benzyl group which may be substituted with an alkyl group of 1 to 6 carbon atoms which may be substituted, a halogen atom, an alkoxy group of 1 to 6 carbon atoms which may be substituted, an amino group which may be substituted, a cyano group, or a nitro group; R 2 and R 3 each independently represent an alkyl group of 1 to 4 carbon atoms; L represents a linker site; and "Polymer" represents a polymer chain).

公开(公告)号：EP3849340B1

公开(公告)日：2023-12-13

申请号：EP19765255.5

申请日：2019-09-10

Inventor： KAPFERER, Peter ,  LUETHI, Erika ,  SEIDEL, Thomas Maximilian

IPC: A23K50/10 ,  C07C201/02 ,  C07C203/04 ,  A61K31/04 ,  A61K31/21

公开(公告)号：EP4245750A1

公开(公告)日：2023-09-20

申请号：EP21891014.9

申请日：2021-11-02

Applicant: YIWUHUAYAO PHARMACEUTICAL TECHNOLOGY CO., LTD

Inventor： WANG, Jianping

IPC: C07C237/08 ,  C07C231/12 ,  C07C231/02 ,  C07C233/25 ,  C07C213/02 ,  C07C217/02 ,  C07C201/12 ,  C07C205/37 ,  C07C41/22 ,  C07C43/225 ,  C07F9/54 ,  A61K31/661 ,  A61K31/167 ,  A61P35/00 ,  A61P35/02

Abstract: Disclosed is an amino-combretastatin derivative, and in particular a compound represented by general formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof, or a hydrate of the pharmaceutically acceptable salt thereof, a solvate thereof or a solvate of the pharmaceutically acceptable salt thereof, and an isomer thereof. In general formula (I),

R 1 is selected from a C1-C3 alkyl or a C1-C3 haloalkyl, and R 2 and R 3 are respectively and independently selected from a C1-C6 alkyl, a C1-C6 haloalkyl or a C1-C6 alcohol group. The present invention also relates to the use of such compounds in the preparation of drugs for the treatment of diseases caused by abnormal neovascularization, and tubulin aggregation inhibitors.

公开(公告)号：EP4143156A1

公开(公告)日：2023-03-08

申请号：EP21721522.7

申请日：2021-04-27

Applicant: ISOMEDIC

Inventor： LECOMTE-NORRANT, Edith ,  MEMBRAT, Romain

IPC: C07C231/02 ,  C07C233/25 ,  C07C201/08 ,  C07C215/76

公开(公告)号：EP4139279A1

公开(公告)日：2023-03-01

申请号：EP21720269.6

申请日：2021-04-21

Applicant: DSM IP Assets B.V.

Inventor： RIEBEL, Peter Hans ,  WILDERMANN, Angela

IPC: C07C201/02 ,  C07C67/08 ,  C07C69/16 ,  C07C203/04

公开(公告)号：EP4139278A1

公开(公告)日：2023-03-01

申请号：EP21720268.8

申请日：2021-04-21

Applicant: DSM IP Assets B.V.

Inventor： RIEBEL, Peter Hans ,  WILDERMANN, Angela

IPC: C07C201/02 ,  C07C67/08 ,  C07C69/16 ,  C07C203/04