公开(公告)号：EP3456705A1

公开(公告)日：2019-03-20

申请号：EP17795980.6

申请日：2017-04-27

Applicant: Kumiai Chemical Industry Co., Ltd.

Inventor： NAKAMURA, Takayuki ,  KATO, Akira ,  ENOMOTO, Masaki ,  TAFUJI, Jun

IPC: C07C201/10 ,  C07C205/12 ,  C07C205/58 ,  C07B61/00

Abstract: The purpose of the present invention to provide a method for producing a nitrobenzene compound represented by general formula (1), which is economically preferable, and suitable for industrialization. The present invention pertains to a method for producing a nitrobenzene compound represented by general formula (1)

(in the formula, R 1 represents a halogen atom; R 2 , R 3 , and R 4 represent a hydrogen atom or the like; R 5 represents a halogen atom or an alkoxycarbonyl group), comprising: (i) a step for reacting an aniline compound represented by general formula (2)

(in the formula, R 1 , R 2 , R 3 , R 4 , and R 5 are as defined above) with a metal salt of nitrous acid in the presence of nitric acid; and (ii) a step for reacting the product of step (i) with a metal salt of nitrous acid in the presence of a copper compound.

公开(公告)号：EP0346185B1

公开(公告)日：1992-12-30

申请号：EP89401485.1

申请日：1989-05-31

Applicant: W.R. Grace & Co.-Conn.

Inventor： Mari, Roger ,  Quibel, Jacques

IPC: C07C205/02 ,  C07C201/10

CPC classification number: C07C201/06 ,  C07C205/02

公开(公告)号：EP2678302A1

公开(公告)日：2014-01-01

申请号：EP12704796.7

申请日：2012-02-17

Applicant: Fundació Institut Català d'Investigació Química

Inventor： GRUSHIN, Vladimir ,  ZANARDI, Alessandro

IPC: C07C17/32 ,  C07C201/10 ,  C07C22/08 ,  C07B39/00 ,  C07C31/28 ,  C07F1/00

CPC classification number: C07F1/08 ,  C07B39/00 ,  C07C17/32 ,  C07C41/30 ,  C07C45/455 ,  C07C45/68 ,  C07C201/12 ,  C07F1/005 ,  C07C22/08 ,  C07C205/11 ,  C07C43/225 ,  C07C49/80

Abstract: Process to obtain a trifluoromethylating composition which comprises the reaction between a copper (I) source and a base in the presence of a solvent and between the resulting cuprating reagent with fluoroform.

公开(公告)号：EP1635790A1

公开(公告)日：2006-03-22

申请号：EP04749055.2

申请日：2004-06-23

Applicant: NICOX S.A.

Inventor： GUSTAFSSON, Christina ,  KJELLBERG, Ulf ,  MOREIN, Sven

IPC: A61K9/18 ,  A61K9/16 ,  A61K31/216 ,  A61P29/00 ,  C07C201/10

CPC classification number: A61K9/4858 ,  A61K9/1617 ,  A61K9/4866 ,  A61K31/216

Abstract: The present invention relates to particles comprising the drug 2-[2-(nitrooxy)ethoxy]ethyl {2-[(2,6-dichlorophenyl)amino]phenyl}acetate, optionally mixed with one or more surfactant(s) and to a new drug delivery composition comprising said particles optionally in combination with a second drug. Furthermore, the invention relates to processes for preparing said particles and drug delivery composition as well as the use of said composition in the manufacturing of a medicament.

公开(公告)号：EP0626366B1

公开(公告)日：1998-01-14

申请号：EP94401124.6

申请日：1994-05-20

Applicant: RHONE-POULENC CHIMIE

Inventor： Metivier, Pascal ,  Bernard, Laurent

IPC: C07C205/22 ,  C07C207/04 ,  C07C205/37 ,  C07C205/26 ,  C07C201/10

CPC classification number: C07C201/00 ,  C07C201/08 ,  C07C205/22 ,  C07C207/04

公开(公告)号：EP4305018A2

公开(公告)日：2024-01-17

申请号：EP22712763.6

申请日：2022-03-09

Applicant: Amgen Inc.

Inventor： CAILLE, Sebastien ,  MURRAY, James ,  QUASDORF, Kyle ,  NGUYEN, Hannah ,  SILVA ELIPE, Maria Victoria ,  ERICSON, Ari Elizabeth

IPC: C07C201/10 ,  C07C205/12

公开(公告)号：EP3015451B1

公开(公告)日：2018-01-17

申请号：EP14817123.4

申请日：2014-06-03

Applicant: Kumiai Chemical Industry Co., Ltd.

Inventor： IKUMI, Akiko ,  NAKAMURA, Takayuki

IPC: C07C205/12 ,  C07C205/58 ,  C07B61/00 ,  C07C201/10

CPC classification number: C07C201/10 ,  C07C205/58 ,  C07C205/12

Abstract: The purpose of the present invention is to provide an economically favorable, industrialization-suitable method for manufacturing nitrobenzene compounds of general formula (1). A method for manufacturing nitrobenzene compounds of general formula (1): (in the formula, R 1 represents a halogen atom; R 2 , R 3 , and R 4 represent a hydrogen atom, etc.; and R 5 represents a halogen atom or alkoxy carbonyl group), the method including the following processes: (i) a process for reacting aniline compounds of general formula (2): (in the formula, R 1 , R 2 , R 3 , R 4 , and R 5 are as previously defined.) in the presence of a metal salt of nitrous acid and an acid, and (ii) a process for reacting the product of process (i) in the presence of a metal salt of nitrous acid and a copper compound; and the total amount of water used in process (ii) being 1.2-2.2 L (liters) with respect to one mole of the compound of general formula (2).

公开(公告)号：EP3015451A4

公开(公告)日：2017-03-01

申请号：EP14817123

申请日：2014-06-03

Applicant: IHARA CHEMICAL IND CO

Inventor： IKUMI AKIKO ,  NAKAMURA TAKAYUKI

IPC: C07C205/12 ,  C07B61/00 ,  C07C201/10 ,  C07C205/58

CPC classification number: C07C201/10 ,  C07C205/58 ,  C07C205/12

Abstract: The purpose of the present invention is to provide an economically favorable, industrialization-suitable method for manufacturing nitrobenzene compounds of general formula (1). A method for manufacturing nitrobenzene compounds of general formula (1): (in the formula, R 1 represents a halogen atom; R 2 , R 3 , and R 4 represent a hydrogen atom, etc.; and R 5 represents a halogen atom or alkoxy carbonyl group), the method including the following processes: (i) a process for reacting aniline compounds of general formula (2): (in the formula, R 1 , R 2 , R 3 , R 4 , and R 5 are as previously defined.) in the presence of a metal salt of nitrous acid and an acid, and (ii) a process for reacting the product of process (i) in the presence of a metal salt of nitrous acid and a copper compound; and the total amount of water used in process (ii) being 1.2-2.2 L (liters) with respect to one mole of the compound of general formula (2).

公开(公告)号：EP2702034A4

公开(公告)日：2015-03-25

申请号：EP12777520

申请日：2012-04-27

Applicant: REDDYS LAB LTD DR

Inventor： KATKAM SRINIVAS ,  SAGYAM RAJESWAR REDDY ,  MORTHALA RAGHAVENDAR RAO ,  IRENI BABU ,  VINIGARI KRISHNA ,  RAMDOSS SURESH KUMAR ,  RANGINENI SRINIVASULU ,  TUMMALA ARJUNKUMAR ,  IQBAL JAVED ,  ORUGANTI SRINIVAS ,  KANDAGATLA BHASKAR

IPC: C07C211/00 ,  C07C201/10 ,  C07C201/12 ,  C07C213/02 ,  C07D333/20

CPC classification number: C07C205/45 ,  C07C201/10 ,  C07C201/12 ,  C07C213/00 ,  C07C213/02 ,  C07C213/10 ,  C07C215/28 ,  C07C205/04

公开(公告)号：EP0626366A1

公开(公告)日：1994-11-30

申请号：EP94401124.6

申请日：1994-05-20

Applicant: RHONE-POULENC CHIMIE

Inventor： Metivier, Pascal ,  Bernard, Laurent

IPC: C07C205/22 ,  C07C207/04 ,  C07C205/37 ,  C07C205/26 ,  C07C201/10

CPC classification number: C07C201/00 ,  C07C201/08 ,  C07C205/22 ,  C07C207/04

Abstract: La présente invention a pour objet un procédé de préparation de nitrophénols. Plus particulièrement, l'invention concerne la préparation de p-nitrophénol.
Le procédé de préparation de l'invention qui consiste à préparer le p-nitrophénol par nitrosation du phénol en présence d'acide sulfurique, puis oxydation du p-nitrosophénol par l'acide nitrique est caractérisé par le fait que dans la première étape de nitrosation, la concentration en acide sulfurique est au moins égale à 60 % et dans la deuxième étape, en fin de réaction d'oxydation, la concentration en acide sulfurique est au plus égale à 80 % ce qui permet de précipiter le p-nitrophénol qui est ensuite séparé.

Abstract translation: 本发明的主题是制备硝基酚的方法。 更具体地说，本发明涉及对硝基苯酚的制备。 本发明的制备方法，其特征在于在硫酸存在下通过亚硝化苯酚然后用硝酸氧化对亚硝基苯来制备对硝基苯酚，其特征在于，在第一亚硝化阶段， 硫酸至少等于60％，而在第二阶段，在氧化反应结束时，硫酸的浓度至多等于80％，这使得有可能沉淀出对硝基苯酚，然后将其分离 。