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    FLUOROALKYLATING AGENT
    1.
    发明公开
    FLUOROALKYLATING AGENT 审中-公开
    FLUORALKYLIERENDES MITTEL

    公开(公告)号：EP3162799A4

    公开(公告)日：2017-08-02

    申请号：EP15810808

    申请日：2015-06-24

    申请人： IHARA CHEMICAL IND CO ,  KUMIAI CHEMICAL INDUSTRY CO

    发明人： KAWAZOE KENTARO ,  YOSHIOKA KOTARO

    IPC分类号： C07D235/10 ,  C07B61/00 ,  C07C29/38 ,  C07C31/38 ,  C07C319/14 ,  C07C323/12

    CPC分类号： C07D235/10 ,  C07B61/00 ,  C07C29/38 ,  C07C31/38 ,  C07C67/343 ,  C07C319/14 ,  C07C319/20 ,  C07C323/12 ,  C07D213/30 ,  C07D333/16

    摘要： Problem to be Solved It is intended to provide an industrially preferable fluoroalkylating agent and use thereof. Solution The present invention provides a fluoroalkylating agent represented by the general formula (1) wherein R 1 is a C1 to C8 fluoroalkyl group; R 2 and R 3 are each independently a C1 to C12 alkyl group or the like; Y 1 to Y 4 are each independently a hydrogen atom, a halogen atom, or the like; and X - is a monovalent anion. A compound of the general formula (3): R 4 -S-R 1 having an introduced C1 to C8 fluoroalkyl group is easily obtained by reacting a compound of the general formula (2): R 4 -S-Z wherein R 4 is a hydrocarbon group or the like; and Z is a leaving group, with the compound of the general formula (1).

    摘要翻译： 要解决的问题旨在提供工业上优选的氟烷基化剂及其用途。 解决方案本发明提供由通式（1）表示的氟烷基化剂，其中R 1是C1-C8氟烷基; R 2和R 3各自独立地为C1至C12烷基等; Y 1至Y 4各自独立地为氢原子，卤素原子等; 而X - 是一种单价阴离子。 通式（3）的化合物：具有引入的C 1至C 8氟烷基的R 4 -SR 1容易通过使通式（2）的化合物：R 4 -SZ（其中R 4为烃基）或 类似; Z是离去基团，与通式（1）的化合物反应。

    NITROBENZENE COMPOUND MANUFACTURING METHOD
    3.
    发明公开
    NITROBENZENE COMPOUND MANUFACTURING METHOD 有权
    的连接方法硝基苯

    公开(公告)号：EP2754651A4

    公开(公告)日：2015-03-11

    申请号：EP12807434

    申请日：2012-07-04

    申请人： IHARA CHEMICAL IND CO

    发明人： TANI SHINKI ,  YADOMATSU NAMI ,  IKUMI AKIKO ,  HIRANO YUUKI ,  IDO TAKUYA

    IPC分类号： C07C201/06 ,  C07B61/00 ,  C07C205/06 ,  C07C227/08 ,  C07C229/56

    CPC分类号： C07C201/06 ,  C07C205/06 ,  C07C205/58

    摘要： There is provided a method for producing a nitrobenzene compound that can be implemented by a simple operation under mild conditions without using a special reaction apparatus. [Solution] The present invention provides a method for producing a nitrobenzene compound represented by general formula (2), wherein R 1 and R 5 are the same or different, and each is a halogen atom or another functional group, and R 2 , R 3 , and R 4 are the same or different, and each is a hydrogen atom or another functional group, comprising oxidizing an aniline compound represented by general formula (1), wherein R 1 , R 2 , R 3 , R 4 , and R 5 are the same as described above, with hydrogen peroxide in the presence of a tungsten compound under an acidic condition, followed by oxidation with hydrogen peroxide under a neutral to alkaline condition.

    N-CYCLOPROPYL-2-DIFLUOROMETHOXY-3-HALOGENOANILINES AND INTERMEDIATES FOR THE PREPARATION THEREOF
    10.
    发明公开
    N-CYCLOPROPYL-2-DIFLUOROMETHOXY-3-HALOGENOANILINES AND INTERMEDIATES FOR THE PREPARATION THEREOF 有权
    N-CYCLOPROPYL-2-DIFLUORMETHOXY-3-HALOGEN-ANILINE UND ZWISCJHENPRODUKTE ZU IHRER HERSTELLUNG

    公开(公告)号：EP1031555A4

    公开(公告)日：2002-10-30

    申请号：EP99937023

    申请日：1999-08-11

    申请人： IHARA CHEMICAL IND CO

    发明人： YOSHIDA YASUO ,  TAKEUCHI HIROAKI

    IPC分类号： C07C205/26 ,  C07C205/37 ,  C07C217/84 ,  C07C229/30 ,  C07D215/56

    CPC分类号： C07D215/56 ,  C07C205/26 ,  C07C205/37 ,  C07C217/84 ,  C07C229/30 ,  C07C2601/02

    摘要： The main tasks of the present invention are to provide, from a raw material which is industrially inexpensive and easy to procure, an N-cyclopropyl-2-difluoromethoxy-3-halogenoaniline which is an important intermediate in production of a quinolonecarboxylic acid having a cyclopropyl group at the 1-position, an isoindolinyl group at the 7-position and a difluoromethoxy group at the 8-position, useful as a synthetic antibacterial agent; and an intermediate used for production thereof. The present invention provides: a difluoromethoxybenzene derivative represented by the following formula (1): wherein X is a halogen atom and Y is a nitro group or an amino group; an N-(1-alkoxycyclopropyl)-2-difluoromethoxy-3-halogenoaniline derivative represented by the following formula (2): wherein X is a halogen atom and R is a lower alkyl group; and an N-cyclopropyl-2-difluoromethoxy-3-halogeno-aniline derivative represented by the following formula (3): wherein X is a halogen atom and R is a hydrogen atom or a 2,2-di(alkoxycarbonyl)ethylene group represented by the following formula (4): -CH=C(CO 2R )2 (wherein R is a lower alkyl group).

    摘要翻译： 本发明的主要任务是从工业上廉价且易于获得的原料中提供N-环丙基-2-二氟甲氧基-3-卤代苯胺，其是生产具有环丙基的喹啉酮羧酸的重要中间体 1-位，7-位的异吲哚啉基和8-位的二氟甲氧基，可用作合成抗菌剂; 和用于其生产的中间体。 本发明提供：由下式（1）表示的二氟甲氧基苯衍生物：其中X为卤素原子，Y为硝基或氨基的 由下式（2）表示的N-（1-烷氧基环丙基）-2-二氟甲氧基-3-卤代苯胺衍生物：其中X是卤素原子，R 1是低级烷基; 和由下式（3）表示的N-环丙基-2-二氟甲氧基-3-卤代苯胺衍生物：其中X是卤素原子，R是氢原子或2,2-二（烷氧基羰基） 由下式（4）表示的亚乙基：-CH = C（CO 2/2）2（其中R 2是低级烷基）。