公开(公告)号：EP3690053A1

公开(公告)日：2020-08-05

申请号：EP18862737.6

申请日：2018-09-20

申请人： Green Cross Corporation ,  Mogam Institute for Biomedical Research

发明人： KIM, So Ra ,  JUNG, Myung Eun ,  KIM, Min Jung ,  JO, Seung Hyun ,  HWANG, Sung Ho ,  KWAK, Hee Chun ,  LEE, Su Min ,  NAM, Hyun Ja

IPC分类号： C12N15/85 ,  C12N15/10 ,  C12N15/113 ,  C12N9/22 ,  C12N9/10 ,  C12N9/64 ,  A01K67/027

摘要： The present invention relates to a factor VIII or factor IX gene knockout rabbit, a method for preparing the same and a use thereof and, more particularly, to a transgenic rabbit whose factor VIII or factor IX gene has been knocked out through the CRISPR/Cas9 system, a method for preparing the same and a use thereof. According to the present invention, in the transgenic rabbit, whose factor VIII and/or factor IX gene has been knocked out, the functions of factor VIII and/or factor IX, which are proteins that perform critical functions for the development of hemophilia, are inhibited, such that the transgenic rabbit is useful for the development of hemophilia treatments.

公开(公告)号：EP2714032B1

公开(公告)日：2019-01-16

申请号：EP12793162.4

申请日：2012-06-01

申请人： Green Cross Corporation

发明人： CHOI, Soongyu ,  SONG, Kwang-Seop ,  LEE, Suk Ho ,  KIM, Min Ju ,  SEO, Hee Jeong ,  PARK, Eun-Jung ,  KONG, Younggyu ,  PARK, So Ok ,  KANG, Hyunku ,  JUNG, Myung Eun ,  LEE, Kinam ,  KIM, Hyun Jung ,  LEE, Jun Sung ,  LEE, Min Woo ,  KIM, Mi-Soon ,  HONG, Dong Ho ,  KANG, Misuk

IPC分类号： A61K31/357 ,  A61K31/343 ,  A61K31/35 ,  A61K31/015 ,  A61P3/00 ,  C07D309/10 ,  C07D405/14 ,  C07D405/10 ,  C07D407/04 ,  C07D407/10 ,  C07D407/14 ,  C07D409/04 ,  C07D409/10 ,  C07D411/10 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D413/12 ,  C07D409/14

公开(公告)号：EP2714032A2

公开(公告)日：2014-04-09

申请号：EP12793162.4

申请日：2012-06-01

申请人： Green Cross Corporation

发明人： CHOI, Soongyu ,  SONG, Kwang-Seop ,  LEE, Suk Ho ,  KIM, Min Ju ,  SEO, Hee Jeong ,  PARK, Eun-Jung ,  KONG, Younggyu ,  PARK, So Ok ,  KANG, Hyunku ,  JUNG, Myung Eun ,  LEE, Kinam ,  KIM, Hyun Jung ,  LEE, Jun Sung ,  LEE, Min Woo ,  KIM, Mi-Soon ,  HONG, Dong Ho ,  KANG, Misuk

IPC分类号： A61K31/357 ,  A61K31/343 ,  A61K31/35 ,  A61K31/015 ,  A61P3/00

CPC分类号： C07D309/10 ,  C07D405/10 ,  C07D405/14 ,  C07D407/04 ,  C07D407/10 ,  C07D407/14 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07D411/10 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14

摘要： The present invention relates to a compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The present invention also provides a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.

公开(公告)号：EP2137156B1

公开(公告)日：2013-08-28

申请号：EP08723343.3

申请日：2008-03-07

申请人： Green Cross Corporation

发明人： LEE, Jinhwa ,  KIM, Jeongmin ,  JUNG, Myung Eun ,  KIM, Jong Yup ,  SONG, Kwang-Seop ,  SON, Eun Jung ,  LEE, Suk Ho ,  HAN, Ho Kyun ,  KIM, Min Ju ,  LEE, MinWoo

IPC分类号： C07D221/28 ,  A61K31/485 ,  A61P25/16

CPC分类号： C07D221/28

公开(公告)号：EP2137156A1

公开(公告)日：2009-12-30

申请号：EP08723343.3

申请日：2008-03-07

申请人： Green Cross Corporation

发明人： LEE, Jinhwa ,  KIM, Jeongmin ,  JUNG, Myung Eun ,  KIM, Jong Yup ,  SONG, Kwang-Seop ,  SON, Eun Jung ,  LEE, Suk Ho ,  HAN, Ho Kyun ,  KIM, Min Ju ,  LEE, MinWoo

IPC分类号： C07D221/28 ,  A61K31/485 ,  A61P25/16

CPC分类号： C07D221/28

摘要： The present invention is directed to a novel prodrug of (+)-3-hydroxymorphinan compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the same, and its use for preventing or treating Parkinson's disease.

公开(公告)号：EP2097410A1

公开(公告)日：2009-09-09

申请号：EP07833072.7

申请日：2007-09-28

申请人： Green Cross Corporation

发明人： LEE, Jinhwa ,  KIM, Jeong Min ,  CHANG, Chong-Hwan Jonathan ,  LEE, Suk Ho ,  SEO, Hee Jeong ,  KANG, Suk Youn ,  SONG, Kwang-Seop ,  KIM, Jong Yup ,  KIM, Min Ju ,  LEE, Sung-Han ,  AHN, Kwang-Woo ,  JUNG, Myung Eun

IPC分类号： C07D419/04 ,  C07D413/04 ,  C07D249/08 ,  C07D269/02 ,  C07D271/06 ,  C07D285/02 ,  A61K31/415 ,  A61K31/4155 ,  A61P3/04

CPC分类号： C07D413/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： A heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The present invention also provides a method for preparing the inventive heteroaryl-pyrasole compounds or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.

摘要翻译： 式（I）的杂芳基 - 吡唑化合物或其药学上可接受的盐作为大麻素CB1受体反向激动剂或拮抗剂是有效的，其可用于预防或治疗肥胖症和肥胖症相关的代谢紊乱。 本发明还提供了用于制备本发明的杂芳基 - 吡唑啉化合物或其药学上可接受的盐的方法，包含其的药物组合物，以及用于预防或治疗肥胖症和肥胖症相关的代谢紊乱的方法。