公开(公告)号：EP1644473B1

公开(公告)日：2014-01-15

申请号：EP04785794.1

申请日：2004-05-28

申请人： Cantimer Incorporated

发明人： STEWART, Ray F.

IPC分类号： G01N33/543 ,  G01Q70/18 ,  G01Q60/38

CPC分类号： G01N33/54373

公开(公告)号：EP3832318A1

公开(公告)日：2021-06-09

申请号：EP19841178.7

申请日：2019-06-28

申请人： Universidad Politécnica De Madrid

发明人： PÉREZ RIGUEIRO, José ,  GUINEA TORTUERO, Gustavo Víctor ,  DAZA GARCÍA, Rafael ,  COLCHERO PAETZ, Luis

IPC分类号： G01Q70/18 ,  G01Q60/42

摘要： The invention relates to a method for obtaining a functionalised sensor tip for atomic force microscopy, which is characterised in that functionalisation takes place by means of an activated vapour silanisation process, comprising: a) evaporating an organometallic compound containing at least one silicon atom and at least one functional group selected from an amine group, a hydroxyl group, a carboxyl group and a thiol group; b) activating the vapour of the organometallic compound of step a) by heating; and c) causing the activated vapour of step b) to impinge on a sensor tip for atomic force microscopy in order to deposit a film of the organometallic compound on the sensor tip, steps b) and c) taking place consecutively. The invention also relates to the functionalised sensor tip obtained using the method.

公开(公告)号：EP3767308A1

公开(公告)日：2021-01-20

申请号：EP19186234.1

申请日：2019-07-15

申请人： Imec VZW

发明人： Hantschel, Thomas

IPC分类号： G01Q70/18 ,  B29C33/42 ,  G01Q70/06 ,  B29C33/38 ,  H01L21/687 ,  G03F7/20

摘要： The invention is related to a reconditioning wafer (1) comprising a carrier substrate (2) that supports at least one array of regularly spaced protrusions (3,5,6,7+8) suitable for forming indentations in a support surface of a wafer holding stage. The protrusions within the same array have essentially the same shape and the same dimensions, thereby enabling a more reliable reconditioning process compared to prior art solutions. The protrusions may have the form of pyramids (3) or pillars (6) or other similar shapes with at least the tip of the protrusions formed of a material suitable for making the indentations. The reconditioning wafer is obtainable by a molding technique wherein an array of molds (11) is created in a mold substrate (10), after which the molds are filled with an indentation material such as diamond, and bonded to the carrier substrate (2), after which the mold substrate is removed by thinning and wet etching.

公开(公告)号：EP1622500A4

公开(公告)日：2007-01-24

申请号：EP04750985

申请日：2004-04-30

申请人： BIOFORCE NANOSCIENCES INC

发明人： HENDERSON ERIC R ,  JOHNSON JAMES ,  NETTIKADAN SAJU

IPC分类号： C12Q1/68 ,  G01Q80/00 ,  A61B20060101 ,  G01N1/31 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01Q10/00 ,  G01Q60/00 ,  G01Q60/18 ,  G01Q60/20 ,  G01Q70/18

CPC分类号： C12Q1/6816 ,  G01N33/54366 ,  G01N33/5438 ,  G01N33/6854 ,  G01Q60/20 ,  C12Q2565/501 ,  C12Q2565/601

摘要： Provided are methods of detecting molecular interactions using arrays and near field scanning probe techniques. Also provided are methods of characterizing binding interactions under defined reaction parameters, methods of determining antibody binding specificity, methods of selecting a substrate for an array of immobilized molecules and methods of determining molecular occupancy time with respect to binding interactions.

公开(公告)号：EP1451374A4

公开(公告)日：2006-04-26

申请号：EP02802883

申请日：2002-11-08

申请人： UNIV TEXAS

发明人： HARRIS ADRON ,  MAYFIELD DAYNE R ,  LEWOHL JO ,  DODD PETER R

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01Q80/00 ,  C07H21/04 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  G01N33/48 ,  G01N33/50 ,  G01N33/566 ,  G01Q70/18 ,  G06F19/00

CPC分类号： C12Q1/6837 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2539/101

摘要： A device and method for detecting, diagnosing, and or monitoring alcoholism and related disease states is disclosed. The device includes a substrate and one or more alcoholism-specific nucleic acids attached to the substrate. The substrate is contacted by a sample collected from a person with alcoholism or alcohol abuse or an alcohol related disease state, wherein contact occurs under pre-selected binding conditions that provides information that can be collected and recorded by a computer.

公开(公告)号：EP1436424A4

公开(公告)日：2005-11-16

申请号：EP02773473

申请日：2002-09-18

申请人： US GENOMICS INC

发明人： CHAN EUGENE Y ,  FUCHS MARTIN ,  GILMANSHIN RUDOLF

IPC分类号： G01N33/53 ,  G01Q80/00 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/543 ,  G01N33/566 ,  G01N33/58 ,  G01Q60/00 ,  G01Q70/18

CPC分类号： C12Q1/6869 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q2565/629 ,  C12Q2565/102 ,  C12Q2563/107

摘要： The invention provides methods and systems for improved spatial resolution of signal detection, particularly as applied to the analysis of polymers such as biological polymers. The methods and systems comprise differentially tagging polymers in order to increase resolution.

公开(公告)号：EP3623821A1

公开(公告)日：2020-03-18

申请号：EP18382665.0

申请日：2018-09-14

申请人： Consejo Superior de Investigaciones Científicas (CSIC)

发明人： Martínez Orellana, Lidia ,  Huttel, Yves

IPC分类号： G01Q60/06 ,  G01Q70/18 ,  G01Q60/08

摘要： The invention relates to a system suitable for its use in scanning probe microscopy, such as tip-enhanced Raman spectroscopy or magnetic force microscopy, that comprises: a tip (1) comprising an apex (1'); a plurality of nanoparticles (2, 2') attached to the tip (1); having a size between 0.5 and 100 nm. Advantageously, the plurality of nanoparticles (2, 2') comprises a cluster (2") of one or more nanoparticles (2') disposed at the apex (1') of the tip (1), wherein the cluster (2") is spaced from any other nanoparticle (2) of the tip (1) at least a distance d of 0.5 nm. The invention also relates to a method for obtaining such system through a controlled thermal treatment that exploits the intrinsic properties of nanoparticles.

公开(公告)号：EP1623953A4

公开(公告)日：2011-10-26

申请号：EP04729206

申请日：2004-04-23

申请人： NAT INST INF & COMM TECH

发明人： OTOMO AKIRA ,  FURUMI SEICHI ,  MIKI HIDEKI ,  SUZUKI HITOSHI ,  TANAKA SHUKICHI ,  MASHIKO SHINRO

IPC分类号： B82B3/00 ,  B82B1/00 ,  G01Q60/16 ,  G01Q60/24 ,  G01Q60/38 ,  G01Q60/42 ,  G01Q60/54 ,  G01Q70/10 ,  G01Q70/14 ,  G01Q70/16 ,  G01Q70/18 ,  G01Q80/00

CPC分类号： G01Q70/18

公开(公告)号：EP1563275A4

公开(公告)日：2010-10-27

申请号：EP03781361

申请日：2003-10-21

申请人： ALEGIS MICROSYSTEMS

发明人： ALLEN MICHAEL JOHN ,  GHISLAIN LUCIEN

IPC分类号： C12Q1/02 ,  G01Q20/02 ,  G01Q30/14 ,  G01Q70/18 ,  G01N11/00

CPC分类号： G01N33/558 ,  C12Q1/02

公开(公告)号：EP4382919A1

公开(公告)日：2024-06-12

申请号：EP22852532.5

申请日：2022-02-03

申请人： Hitachi, Ltd.

发明人： KOGUCHI, Masanari

IPC分类号： G01Q70/14 ,  G01K11/30 ,  G01Q70/18

CPC分类号： G01Q80/00 ,  G01K11/20 ,  G01Q70/14 ,  G01Q70/18 ,  G01K11/30

摘要： Between a nitrogen-vacancy center and a support portion, a cut-off portion is provided that cuts off the nitrogen-vacancy center from the support portion.