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    ULTRASONICALLY-ENHANCED CONTINUOUS AND LARGE-SCALE PRODUCTION METHOD FOR NANO-FORMULATIONS
    2.
    发明公开
    ULTRASONICALLY-ENHANCED CONTINUOUS AND LARGE-SCALE PRODUCTION METHOD FOR NANO-FORMULATIONS 审中-公开

    公开(公告)号：EP4450045A1

    公开(公告)日：2024-10-23

    申请号：EP22906581.8

    申请日：2022-12-13

    申请人： Shanghai Best-Link Bioscience, LLC

    发明人： ZHANG, Fuyao ,  WAN, Jiaxun

    IPC分类号： A61J3/00 ,  A61K9/08 ,  A61K9/107 ,  A61K9/127 ,  A61K31/4745 ,  A61K41/00 ,  A61K45/00 ,  A61P35/00 ,  B82Y5/00

    摘要： Disclosed is an ultrasonically-enhanced continuous and large-scale production method for nano-formulations. Specifically disclosed is a preparation system for continuous production of nano-formulations, comprising (a) a first pipe, (b) a second pipe, (f) an ultrasonic device, (c) a combined pipe and (e) a (fluid) outlet thereof. The first pipe and the second pipe are connected to the combined pipe. A first phase solution enters the combined pipe through a first pipe outlet, and a second phase solution enters the combined pipe through a second pipe outlet. The ultrasonic device acts on the part or the whole of the combined pipe. The first phase solution and the second phase solution are turbulently mixed in the combined pipe to form a combined phase, and flow out through the outlet of the combined pipe. The preparation system and the preparation method of the present invention can remarkably improve the entrap entefficiency of nano-drugs, and improve the uniformity of the particle size of the nano-particles.

    MEDICINE PACKAGING MACHINE
    7.
    发明公开
    MEDICINE PACKAGING MACHINE 审中-实审

    公开(公告)号：EP4397297A1

    公开(公告)日：2024-07-10

    申请号：EP22889826.8

    申请日：2022-10-25

    申请人： Tosho, Inc.

    发明人： OMURA Yoshihito

    IPC分类号： A61J3/00

    CPC分类号： A61J3/00

    摘要： The present invention provides a tablet dispensing apparatus in which the work of cleaning for tablet falling surfaces in an accumulating chute 32 and a gathering chute 33 of a lower tablet collecting mechanism can be easily and accurately carried out. The accumulating chute 32 is forwardly drawn from a housing 11 accompanied by a manual medicine dispensing device 80, and an accumulating chute support member 32A is provided on a drawer mechanism 81, and the accumulating chute 32 can be configured to attach and detach by a hunger 32d on an upper end 32b of the accumulating chute support member 32A. Further, when the accumulating chute 32 is forwardly drawn, the gathering chute 33 can be moved backward along a gathering chute support member 33a, and the gathering chute 33 can be attached and detached by holding a handle member 33c.