公开(公告)号：EP3932545A1

公开(公告)日：2022-01-05

申请号：EP20762503.9

申请日：2020-02-20

申请人： Osaka University ,  N.E. Chemcat Corporation

发明人： KANEDA Kiyotomi ,  MITSUDOME Takato ,  KIMURA Miho ,  TAKAGI Yukio ,  IMANAKA Yosuke ,  SUZUKA Hiroyasu ,  KOJIMA Tatsuya

IPC分类号： B01J27/18 ,  B01J27/19 ,  B01J37/02 ,  B01J37/04 ,  C07B61/00 ,  C07C209/26 ,  C07C209/50 ,  C07C211/03 ,  C07C211/08 ,  C07C211/17 ,  C07C211/27 ,  C07C211/35 ,  C07C211/45 ,  C07D209/44 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D487/08

摘要： Provided is a catalyst for amide compound hydrogenation characterized in that rhodium and molybdenum are supported on hydroxyapatite, the catalyst for amide compound hydrogenation providing a catalyst that can promote a reduction reaction that converts an amide compound into an amine compound, can be used under moderate conditions, and has durability that allows repeated use thereof while retaining high activity. Also provided is a method for producing an amine compound, the method being characterized by including bringing an amide compound into contact with the catalyst for amide compound hydrogenation to cause hydrogenation, thereby producing an amine compound.

公开(公告)号：EP3114107B1

公开(公告)日：2020-07-22

申请号：EP15757721.4

申请日：2015-03-05

申请人： Recurium IP Holdings, LLC

发明人： BUNKER, Kevin Duane

IPC分类号： C07C61/125 ,  C07C235/26 ,  C07C211/19 ,  C07C45/44 ,  C07C47/347 ,  C07C255/46 ,  C07C255/64 ,  C07C271/22 ,  C07C211/35 ,  C07C229/28 ,  C07D249/06 ,  C07C247/14 ,  C07C251/42

公开(公告)号：EP2951188B1

公开(公告)日：2017-05-10

申请号：EP14701708.1

申请日：2014-01-22

申请人： Evonik Degussa GmbH

发明人： FRANKE, Robert ,  DYBALLA, Katrin Marie ,  HESS, Dieter ,  FRIDAG, Dirk ,  HAMERS, Bart ,  BELLER, Matthias ,  JACKSTELL, Ralf ,  FLEISCHER, Ivana ,  WU, Lipeng

IPC分类号： C07F9/572 ,  C07F9/6506 ,  C07B43/04 ,  C07C209/78 ,  C07C211/08 ,  C07C211/27 ,  C07C211/35 ,  C07C211/48 ,  C07C213/00 ,  C07C221/00 ,  C07C225/16 ,  C07D207/04 ,  C07D209/08 ,  C07D295/023 ,  C07D295/03 ,  C07C209/26 ,  C07D295/033 ,  C07C213/02 ,  C07F9/145

CPC分类号： C07F9/5726 ,  C07B43/04 ,  C07C209/26 ,  C07C213/02 ,  C07C221/00 ,  C07C2601/14 ,  C07D207/04 ,  C07D209/08 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033 ,  C07F9/145 ,  C07F9/65066 ,  C07F9/65068 ,  C07C211/08 ,  C07C211/27 ,  C07C215/08 ,  C07C211/48 ,  C07C225/22 ,  C07C211/35

公开(公告)号：EP2930166A4

公开(公告)日：2016-01-06

申请号：EP12889458

申请日：2012-12-07

申请人： WANHUA CHEMICAL GROUP CO LTD ,  NINGBO WANHUA POLYURETHANES CO

发明人： CHEN CHANGSHENG ,  JIANG JINKE ,  CHEN ZHONGYING ,  CUI JIAOYING ,  WANG JING ,  LI FUGUO ,  LV CHENGGE ,  ZHAO WENJUAN ,  LI YUAN ,  HUA WEIQI

IPC分类号： C07C211/35 ,  C07C209/48 ,  C07C209/52

CPC分类号： C07C253/30 ,  C07C209/48 ,  C07C209/52 ,  C07C2101/14 ,  C07C2601/14 ,  C07C255/46 ,  C07C211/36

摘要： The present invention provides a method for preparing 3-aminomethyl-3,5,5-trimethyl cyclohexylamine. The method comprises: a) reacting 3-cyano-3,5,5-trimethyl cyclohexanone with excess primary amine as well as removing the water generated from the reaction, so that IPN is substantially converted into imine compounds; b) in the presence of an ammonolysis catalyst, mixing the product of step a) with liquid ammonia, making the imine compound perform ammonolysis reaction to generate 3-cyano-3,5,5-trimethyl cyclohexylimine and the primary amine; and c) in the presence of hydrogen and a hydrogenation catalyst, hydrogenating 3-cyano-3,5,5-trimethyl cyclohexylimine obtained in step b) to obtain 3-aminomethyl-3,5,5-trimethyl cyclohexylamine. The method of the present invention avoids the generation of 3,5,5-trimethyl cyclohexanol and 3-aminomethyl-3,5,5-trimethyl cyclohexanol as the major by-products in the prior art, thereby improving the yield of 3-aminomethyl-3,5,5-trimethyl cyclohexylamine.

公开(公告)号：EP2581367B1

公开(公告)日：2015-12-30

申请号：EP13150037.3

申请日：2008-04-04

申请人： ZIOPHARM ONCOLOGY, INC.

发明人： Amedio, John C. ,  Wallner, Barbara P. ,  Komarnitsky, Philip B.

IPC分类号： C07D213/74 ,  C07F9/24 ,  A61K31/13 ,  A61K31/133 ,  A61K31/198 ,  A61K31/4409 ,  A61K31/664 ,  C07C211/35 ,  C07C215/10 ,  C07C229/26 ,  C07C279/14 ,  A61P35/00

CPC分类号： C07F9/22 ,  A61K31/337 ,  A61K31/664 ,  A61K31/704 ,  C07D213/74 ,  C07F9/2458

公开(公告)号：EP2834247A2

公开(公告)日：2015-02-11

申请号：EP13772784.8

申请日：2013-04-05

申请人： Dr. Reddy's Laboratories Ltd.

发明人： DAHANUKAR, Vilas Hareshwar ,  GILLA, Goverdhan ,  KURELLA, Sreenivasulu ,  KULKARNI, Shweta Mahajan ,  ANUMULA, Raghupathi Reddy ,  AALLA, Sampath ,  BOJJA, Yakambram ,  ELATI, Ravi Ram Chandra Sekhar ,  MURKI, Veerender ,  CHEEMALAPATI, Venkata Annapurna Sasikala

IPC分类号： C07D487/04 ,  C07C211/35

CPC分类号： C07D487/04 ,  A61K9/146 ,  C07B2200/07 ,  C07C209/44 ,  C07C209/48 ,  C07C253/30 ,  C07C255/46 ,  C07C2601/02 ,  C07C211/40

摘要： The present application relate to processes for preparing Ticagrelor and its intermediates that are useful in the processes. The application further provides salts of Ticagrelor, their processes and solid dispersion of Ticagrelor having Ticagrelor in amorphous form.

公开(公告)号：EP2787550A1

公开(公告)日：2014-10-08

申请号：EP12853562.2

申请日：2012-11-29

申请人： Hitachi Chemical Company, Ltd.

发明人： FUNYUU, Shigeaki ,  ASANO, Naoki ,  ISHITSUKA, Kenichi

IPC分类号： H01L51/50 ,  C08K5/17 ,  C08L101/02 ,  H05B33/02 ,  C07C211/07 ,  C07C211/27 ,  C07C211/35 ,  C07C309/39 ,  C07C317/04 ,  C07F5/02

CPC分类号： H01L51/0035 ,  C08K5/17 ,  H01L51/0004 ,  H01L51/0036 ,  H01L51/0043 ,  H01L51/005 ,  H01L51/0096 ,  H01L51/5012 ,  H01L51/5056 ,  H01L51/506 ,  H01L51/5072 ,  H01L51/5088 ,  H01L51/5092 ,  H01L2251/5338

摘要： Provided is an organic electronic material which is excellent in storage stability in the case as an ink composition, and able to prepare, at a high yield, an organic electronic element capable of reducing the driving voltage and of being driven stably for a long period of time, and an ink composition including the organic electronic material. The organic electronic material is characterized in that it contains at least an ionic compound represented by the following general formula (1), and a compound including a charge transporting unit, and the ink composition including the material.
[In the general formula (1), R a to R c each independently represent a hydrogen atom (H), an alkyl group, or a benzyl group, and N is not bonded to an aryl group. A represents an anion.]

摘要翻译： 本发明提供一种有机电子材料，其在作为油墨组合物的情况下的储存稳定性优异，并且能够以高收率制备能够降低驱动电压并且能够长期稳定地驱动的有机电子元件 时间，以及包含该有机电子材料的墨水组合物。 有机电子材料的特征在于，其至少包含由下述通式（1）表示的离子化合物和包含电荷输送单元的化合物以及包含该材料的油墨组合物。 [通式（1）中，Ra〜Rc分别独立地表示氢原子（H），烷基或苄基，N不与芳基键合。 A代表阴离子。]

公开(公告)号：EP2678306A1

公开(公告)日：2014-01-01

申请号：EP11802039.5

申请日：2011-12-14

申请人： Evonik Degussa GmbH

发明人： KLASOVSKY, Florian ,  TACKE, Thomas ,  PFEFFER, Jan, Christoph ,  HAAS, Thomas ,  BELLER, Matthias ,  MARTIN, Andreas ,  DEUTSCH, Jens ,  KÖCKRITZ, Angela ,  IMM, Sebastian ,  HABERLAND, Jürgen

IPC分类号： C07C209/16 ,  C07C213/02 ,  C07C227/08 ,  C07D213/38 ,  C07D493/04 ,  C07C211/07 ,  C07C211/27 ,  C07C211/35 ,  C07C211/38 ,  C07C217/08 ,  C07C229/08 ,  C07C229/38

CPC分类号： C07C209/16 ,  C07C213/02 ,  C07C227/06 ,  C07C227/08 ,  C07C2601/14 ,  C07C2603/74 ,  C07D213/38 ,  C07D493/04 ,  C07C211/07 ,  C07C211/27 ,  C07C211/35 ,  C07C211/38 ,  C07C217/08 ,  C07C229/08 ,  C07C229/38

摘要： The present invention relates to a chemocatalytic liquid-phase process for the direct single-stage amination of alcohols to primary amines using ammonia in high yields by means of a catalyst system containing at least one transition metal compound and a xantphos ligand.

摘要翻译： 本发明涉及一种化学催化液相方法对醇初级cardamines的通过以高产率使用的催化剂体系包含至少一种过渡金属化合物和配体XANTPHOS氨手段的直接单级阿米娜灰。

公开(公告)号：EP2635551A1

公开(公告)日：2013-09-11

申请号：EP11778894.3

申请日：2011-11-04

申请人： Bayer CropScience AG

发明人： LUI, Norbert ,  MORADI, Wahed Ahmed ,  MÜLLER, Thomas Norbert

IPC分类号： C07C209/52 ,  C07C211/35

CPC分类号： C07C209/52 ,  C07C211/35 ,  C07C213/02 ,  C07C217/58 ,  C07C227/04 ,  C07C251/24 ,  C07C2601/02 ,  C07C229/38 ,  C07C217/56

摘要： The present invention relates to a process for the preparation of substituted N-(benzyl)cyclopropanamines of the general formula (II) starting from N-[(aryl)methylene]cyclopropanamine derivatives. The present invention further provides the N-[(aryl)methylene]cyclopropanamine derivatives used as starting compounds in this process according to the invention, and their use for the preparation of substituted N (benzyl)cyclopropanamines.

摘要翻译： 本发明涉及由N - [（芳基）亚甲基]环丙胺衍生物制备通式（II）的取代的N-（苄基）环丙胺的方法。 本发明进一步提供在本发明方法中用作起始化合物的N - [（芳基）亚甲基]环丙胺衍生物及其用于制备取代的N（苄基）环丙胺的用途。

公开(公告)号：EP2581367A3

公开(公告)日：2013-07-03

申请号：EP13150037.3

申请日：2008-04-04

申请人： ZIOPHARM ONCOLOGY, INC.

发明人： Amedio, John C. ,  Wallner, Barbara P. ,  Komarnitsky, Philip B.

IPC分类号： C07D213/74 ,  C07F9/24 ,  A61K31/13 ,  A61K31/133 ,  A61K31/198 ,  A61K31/4409 ,  A61K31/664 ,  C07C211/35 ,  C07C215/10 ,  C07C229/26 ,  C07C279/14 ,  A61P35/00

CPC分类号： C07F9/22 ,  A61K31/337 ,  A61K31/664 ,  A61K31/704 ,  C07D213/74 ,  C07F9/2458

摘要： Disclosed herein are crystalline compounds of formula (I), wherein A + represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.