公开(公告)号：EP2731926B1

公开(公告)日：2016-12-28

申请号：EP11868928.0

申请日：2011-07-07

申请人： Solvay (Zhangjiagang) Speciality Chemicals Co., Ltd. ,  Rhodia Operations

发明人： LU, Zhongjie ,  DIAO, Shiquan ,  ZHANG, Xinjun ,  XU, Peijun

IPC分类号： C07C209/48 ,  C07C255/24 ,  C07C253/30 ,  B01J19/00 ,  C07C211/11

CPC分类号： C07C253/30 ,  C07C209/48 ,  Y02P20/582 ,  C07C255/25 ,  C07C211/09

公开(公告)号：EP3071572A1

公开(公告)日：2016-09-28

申请号：EP14863267.2

申请日：2014-11-19

申请人： Pharmascience Inc.

发明人： LAURENT, Alain ,  ROSE, Yannick

IPC分类号： C07D487/04 ,  A61P19/02 ,  A61P37/06 ,  C07C255/17 ,  C07C255/24 ,  A61K31/519 ,  C07D207/34 ,  C07D213/30 ,  C07D239/26 ,  C07D277/24 ,  C07D309/06 ,  C07D405/04

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  C07C255/17 ,  C07C255/25 ,  C07C2601/04 ,  C07C2601/08 ,  A61K2300/00

摘要： The present invention relates to a novel family of protein kinase inhibitors, more specifically the present invention is directed to inhibitors of the members of the Tec or Src protein kinase families. The present invention also relates to the processes of preparation of these compounds, their intermediates, to the pharmaceutical compositions comprising them, and to their use in the treatment of proliferative, inflammatory, autoimmune, or infectious disease, disorders, or conditions in which protein kinase activity is implicated. More particularly, the present invention relates to a compound of Formula I.

摘要翻译： 本发明涉及新的蛋白激酶抑制剂家族，更具体地说，本发明涉及Tec或Src蛋白激酶家族成员的抑制剂。 本发明还涉及制备这些化合物，它们的中间体，包含它们的药物组合物的方法，以及它们在治疗增殖性，炎症性，自身免疫性或传染性疾病，病症或其中蛋白激酶 活动被牵连。 更具体地说，本发明涉及式I化合物。

公开(公告)号：EP2581364B1

公开(公告)日：2014-11-19

申请号：EP12195063.8

申请日：2005-09-09

申请人： Invista Technologies S.à.r.l.

发明人： Ostermaier, John, J.

IPC分类号： C07C209/48 ,  C07C253/34 ,  C07C209/86 ,  C07C211/12 ,  C07C255/24

CPC分类号： C07C209/86 ,  C07C253/34 ,  C07C211/12 ,  C07C255/24

公开(公告)号：EP1883623B1

公开(公告)日：2011-04-20

申请号：EP06754975.8

申请日：2006-05-03

申请人： BASF SE

发明人： OFTRING, Alfred ,  JUDAT, Bernd ,  RAULS, Matthias ,  FRIESE, Katrin

IPC分类号： C07C253/34 ,  C07C255/24 ,  C07C255/25

CPC分类号： C07C253/34 ,  C07C255/24 ,  C07C255/25

摘要： The invention relates to a method for isolating methyl glycine nitrile-N,N-diacetonitriles (MGDN) from an MGDN-containing aqueous emulsion with an MGDN content of 3 - 50% by weight in a crystallizer. The inventive method is characterized by (a) cooling the aqueous emulsion, starting from a temperature above the solidification point, to a temperature below the solidification point, the cooling rate in the temporal mean not exceeding 5 K/h, until substantially the total amount of the emulsified MGDN has solidified; and (b) continuing to cool the aqueous suspension obtained and/or concentrating it, the cooling rate being higher than that in step (a).

摘要翻译： 本发明涉及在结晶器中从MGDN含量为3-50重量％的含MGDN的含水乳液中分离甲基甘氨酸腈-N，N-二乙腈（MGDN）的方法。 本发明的方法的特征在于（a）从高于凝固点的温度开始将水性乳液冷却至低于凝固点的温度，冷却速率的时间平均值不超过5K / h，直到基本上达到总量 的乳化MGDN固化; 和（b）继续冷却所得到的含水悬浮液和/或浓缩它，冷却速率高于步骤（a）中的冷却速率。

公开(公告)号：EP2001834A1

公开(公告)日：2008-12-17

申请号：EP07723310.4

申请日：2007-03-16

申请人： Clariant International Ltd.

发明人： CUYPERS, Lars ,  KOEK, Jean Hypolites

IPC分类号： C07C253/30 ,  C07C255/24 ,  C07C255/25

CPC分类号： C07C253/30 ,  C07C303/22 ,  C07C255/25 ,  C07C309/30

摘要： The invention relates to a method for producing compounds of formula (I), wherein R1, R2, R3 and Y are defined as in the description. The method according to the invention is characterized by reacting a tertiary amine of the formula NR1R2R3 with chloracetonitrile in an organic solvent and then adding an acid of the formula HZ.

摘要翻译： 本发明涉及制备式（I）化合物的方法，其中R 1，R 2，R 3和Y如说明书中所定义。 根据本发明的方法的特征在于使式NR 1 R 2 R 3的叔胺与氯乙腈在有机溶剂中反应，然后加入式HZ的酸。

公开(公告)号：EP1487955B1

公开(公告)日：2008-05-21

申请号：EP03714809.5

申请日：2003-03-12

申请人： Clariant Produkte (Deutschland) GmbH

发明人： SEEBACH, Michael ,  REINHARDT, Gerd

IPC分类号： C11D3/39 ,  C07C255/24

CPC分类号： C11D3/3925 ,  C07C255/25

摘要： The invention relates to ammonium nitriles of general formula (I), wherein the radicals R3, R4, R5 and X have the meaning as cited in the description and R1 and R2 respectively represent individually a straight or branched chained C5-C24-alkyl, alkenyl or alkylether group. The inventive compounds are used as bleaching activators in washing, cleaning, and disinfective agents and in textile and paper bleaching.

公开(公告)号：EP1681924A1

公开(公告)日：2006-07-26

申请号：EP04799711.9

申请日：2004-11-10

申请人： ISHIHARA SANGYO KAISHA, LTD.

发明人： MITANI, Shigeru, Ishihara Sangyo Kaisha, Ltd. ,  NAKAYAMA, Hitoshi, Ishihara Sangyo Kaisha, Ltd. ,  SUGIMOTO, Koji, Ishihara Sangyo Kaisha, Ltd. ,  OGAWA, Munekazu, Ishihara Sangyo Kaisha, Ltd.

IPC分类号： A01N37/18 ,  A01N37/40 ,  C07C233/65 ,  C07C233/66 ,  C07C255/24 ,  C07C211/27 ,  C07C235/46 ,  C07C233/05 ,  C07C233/07 ,  C07C233/15 ,  C07C233/25 ,  C07C233/09 ,  C07C243/22 ,  C07C251/04 ,  C07C243/28

CPC分类号： C07D213/40 ,  A01N37/18 ,  A01N37/22 ,  A01N37/40 ,  A01N43/10 ,  A01N43/40 ,  A01N43/653 ,  A01N47/30 ,  A01N47/40 ,  C07C211/27 ,  C07C233/03 ,  C07C233/05 ,  C07C233/07 ,  C07C233/09 ,  C07C233/15 ,  C07C233/25 ,  C07C233/65 ,  C07C233/66 ,  C07C233/67 ,  C07C233/73 ,  C07C235/42 ,  C07C235/46 ,  C07C237/30 ,  C07C243/22 ,  C07C243/28 ,  C07C251/04 ,  C07C251/24 ,  C07C251/48 ,  C07C251/74 ,  C07C255/24 ,  C07C255/25 ,  C07C255/60 ,  C07C275/54 ,  C07C311/09 ,  C07C317/32 ,  C07C317/44 ,  C07C323/42 ,  C07C323/56 ,  C07C323/62 ,  C07C327/48 ,  C07D213/64 ,  C07D213/643 ,  C07D213/75 ,  C07D249/14 ,  C07D277/28 ,  C07D307/52 ,  C07D317/16 ,  C07D333/36

摘要： A pesticide having stabilized high pesticidal effects for crop plants infected with plant diseases, is presented. The pesticide contains a biphenyl derivative represented by the formula (I) or its salt, as an active ingredient: wherein X, Y and Z are each independently a halogen atom, a hydroxyl group, a formyl group, an alkyl group which may be substituted, an alkoxy group which may be substituted, an alkylthio group, an alkylsulfonyl group, an alkylsulfinyl group, or the like, A is a carbonyl group, a thiocarbonyl group, an alkylene group, or a single bond, R1 and R2 are each independently a hydrogen atom, an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, an aryl group which may be substituted, a formyl group, an alkylcarbonyl group, a cyano group, or the like, and m and n are each independently 0, 1, 2, 3 or 4.

公开(公告)号：EP1292569B1

公开(公告)日：2005-11-30

申请号：EP01953979.0

申请日：2001-06-13

申请人： BASF Aktiengesellschaft

发明人： LUYKEN, Hermann ,  OHLBACH, Frank, Dr. ,  FISCHER, Rolf-Hartmuth ,  MELDER, Johann-Peter ,  BASSLER, Peter ,  ANSMANN, Andreas ,  ACHHAMMER, Günther

IPC分类号： C07C253/34 ,  C07C255/24 ,  C07C209/48

CPC分类号： C07C253/34 ,  C07C209/48 ,  Y10S203/20 ,  C07C255/24

摘要： The invention relates to a method for removing, by distillation, 6-aminocapronitrile from mixtures that contain 6-aminocapronitrile, adipodinitrile and hexamethylenediamine, by a) removing the hexamethylenediamine from the mixture while obtaining a mixture (I) that has a hexamethylenediamine content of less than 1 wt.- %, b) removing completely or partially the 6-aminocapronitrile from mixture (I) while obtaining a mixture (II) whose content in substances that have a higher boiling point as 6-aminocapronitrile under distillation conditions and that cannot be formed by dimerization reactions when 6-aminocapronitrile is thermally treated is less than 1 wt.- %, and c) completely or partially removing from mixture (II) the hexamethylenediamine that might be present while obtaining a mixture (IV) whose hexamethylenediamine content is higher than that of mixture (II), and a mixture (V) whose hexamethylenediamine content is lower than that of mixture (II).

公开(公告)号：EP1517877A1

公开(公告)日：2005-03-30

申请号：EP03739199.2

申请日：2003-06-19

申请人： PCBU Services, Inc.

发明人： ALLEN, David, Robert ,  ACHENBACH-MCCARTHY, Crystal

IPC分类号： C07B57/00 ,  C07C253/30 ,  C07C255/24

CPC分类号： C07C253/30 ,  C07B2200/07 ,  C07C255/24

摘要： A process and intermediates for producing 3-amino nitriles. The process involves resolving an enantiomeric mixture of chiral 3-amino nitriles in the presence of a chiral acid in a solvent system to produce a chiral 3-amino nitrile salt. The process may further comprise a recrystalizing step, wherein an enantiomerically enriched 3-amino nitrile salt is produced. The process may further comprise a salt exchanging step, wherein another acid is added to the chiral 3-amino nitrile salt or the enantiomerically enriched 3-amino nitrile salt to produce another 3- amino nitrile salt.

公开(公告)号：EP1062200B1

公开(公告)日：2004-11-10

申请号：EP99912720.2

申请日：1999-03-19

申请人： INVISTA Technologies S.à.r.l.

发明人： IONKIN, Alex, Sergey ,  ZIEMECKI, Stanislaw, Bogdan ,  HARPER, Mark, Jay ,  KOCH, Theodore, Augur

IPC分类号： C07C253/30 ,  C07C255/24

CPC分类号： C07C253/30 ,  C07C255/24

摘要： A process for selectively hydrogenating a dinitrile to an aminonitrile is provided. The process comprises contacting a dinitrile with a hydrogen-containing fluid in the presence of a solvent comprising an alcohol or liquid ammonia, at least one metal catalyst, and a carbonyl group-containing additive such as, for example, organic amides, organic esters, salts of carboxylic acids, or urea.