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    Process for producing mercaptophenols by the hydrogenolysis of polythiobisphenols
    3.
    发明公开
    Process for producing mercaptophenols by the hydrogenolysis of polythiobisphenols 失效
    通过多羟基苯酚的氢化生产辛烯酚的方法

    公开(公告)号：EP0474259A3

    公开(公告)日：1992-04-22

    申请号：EP91117421.7

    申请日：1986-04-29

    申请人： SUMITOMO SEIKA CHEMICALS CO., LTD.

    发明人： Onoe, Akira ,  Kawamura, Masao ,  Nishi, Tadaaki ,  Kobayashi, Kenzo ,  Yoshikawa, Masato

    IPC分类号： C07C319/10 ,  C07C323/10

    CPC分类号： C07C323/00 ,  C07C319/06 ,  C07C323/20

    摘要： A novel process for producing mercaptophenols by the hydrogenolysis of polythiobisphenols in the presence of a nickel catalyst is disclosed. Raney nickel catalyst which is in advance poisoned with an organosulfur compound in which the sulfur atom has unshared electron pairs is especially effective as a catalyst. A process for producing polythiobisphenols which comprises: reacting a phenol having the general formula
    wherein each R independently represents a hydrogen, a halogen or an alkyl, with sulfur monochloride in a polar organic solvent in the presence of a nitrogen-containing organic compound as a catalyst which is selected from the group consisting of tertiary amines, quaternary ammoniums, alkylated acid amides and heteroaromatic compounds, in amounts of about 1-30 % by weight based on the amount of the phenol used. As a catalyst, bromine or an alkali metal halide is also usable.

    Phenethanolamine derivatives
    5.
    发明公开
    Phenethanolamine derivatives 失效
    苯乙醇胺衍生物

    公开(公告)号：EP0317206A2

    公开(公告)日：1989-05-24

    申请号：EP88310661.9

    申请日：1988-11-11

    申请人： GLAXO GROUP LIMITED

    发明人： Mitchell William Leonard ,  Skidmore Ian Frederick ,  Lunts Lawrence Henry Charles ,  Finch Harry ,  Naylor Alan ,  Hartley David

    IPC分类号： C07C215/20 ,  C07C323/10 ,  A61K31/135 ,  A61K31/18

    CPC分类号： C07C65/11 ,  Y10S514/819 ,  Y10S514/826 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/913 ,  Y10S514/925 ,  Y10S514/927

    摘要： The invention provides compounds of the general formula (I)
    and physiologically acceptable salts and solvates thereof, wherein
    Ar represents the group
    where Q¹ represents a straight or branched C₁₋₃alkylene group,
    where Q² represents a group R³CO-, R³NHCO-, R³R⁴NSO₂- or R⁵SO₂-, where R³ and R⁴ each represent a hydrogen atom or a C₁₋₃alkyl group, and R⁵ represents a C₁₋₃alkyl group,
    R represents a hydrogen atom or a C₁₋₃alkyl group;
    R¹ and R² each independently represent a hydrogen atom or a methyl or ethyl group; and
    k represents an integer from 1 to 8;
    m represents zero or an integer from 2 to 7, and;
    n represents an integer from 1 to 7 with the proviso that the sum total of k, m and n is 4 to 12;
    X represents an oxygen or sulphur atom, and;
    Y and Z each represent a bond, or an oxygen or sulphur atom with the proviso that when Y is a bond m is zero, or when Y represents an oxygen or sulphur atom m is an integer from 2 to 7, or when Y and Z each independently represent an oxygen or sulphur atom then n is an integer from 2 to 7;
    Q represents a naphthalenyl group which may optionally be substituted by one or two groups selected from C₁₋₄alkyl, C₁₋₄alkoxy, hydroxy and halogen.
    The compounds have a stimulant action at β₂-­adrenoreceptors and may be used in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.

    摘要翻译： 本发明提供了通式（Ⅰ）的化合物及其生理学上可接受的盐和溶剂化物，其中Ar表示其中Q 1代表直链或支链C 1-3亚烷基的基团，其中Q 2代表基团R 3 CO-，R 3 NHCO-，R 3 R 4 NSO 2 - 或 R 5 SO 2 - ，其中R 3和R 4分别代表氢原子或C 1-3烷基，R 5代表C 1-3烷基，R代表氢原子或C 1-3烷基; R 1和R 2各自独立地代表氢原子或甲基或乙基; k表示1至8的整数; m表示零或2至7的整数，并且; n表示1至7的整数，条件是k，m和n的总和为4至12; X代表氧或硫原子，并且; Y和Z各自表示键或氧或硫原子，条件是当Y是键时m为零，或者当Y表示氧或硫原子时，m为2至7的整数，或者当Y和Z 各自独立地表示氧或硫原子，那么n是2至7的整数; Q代表可任选被一个或两个选自C 1-4烷基，C 1-4烷氧基，羟基和卤素的基团取代的萘基。 这些化合物对β2 - 肾上腺素受体具有刺激作用，并可用于治疗与可逆性气道阻塞相关的疾病，例如哮喘和慢性支气管炎。

    Process for preparing fluorine-substituted alicyclic diols
    6.
    发明公开
    Process for preparing fluorine-substituted alicyclic diols 失效
    Verfahren zur Herstellung von fluorsubstituierten alicyclischen Diolen。

    公开(公告)号：EP0286991A2

    公开(公告)日：1988-10-19

    申请号：EP88105631.1

    申请日：1988-04-08

    申请人： DAIKIN INDUSTRIES, LIMITED

    发明人： Kubo, Motonobu ,  Shimizu, Yoshiki

    IPC分类号： C07C29/19 ,  C07C31/44 ,  C07C43/192 ,  C07C323/10 ,  C07C43/196 ,  C07C321/20

    CPC分类号： C07C31/44

    摘要： A process for preparing a fluorine-substituted alicyclic diol comprising hydrogenating in the presence of a catalyst a fluorine-substituted aromatic diol represented by formula (I):
    wherein Ph represents a divalent organic group containing at least one aromatic group, to obtain the fluorine-­substituted alicyclic diol represented by formula (II):
    wherein Ph(H) represents a divalent organic group containing at least one perhydroaromatic group.

    摘要翻译： 一种制备氟取代的脂环族二醇的方法，包括在催化剂存在下氢化式（I）表示的氟取代的芳族二醇：其中Ph表示含有至少一个芳族基团的二价有机基团，以获得 由式（II）表示的氟取代的脂环族二醇：其中Ph（H）表示含有至少一个全氢芳族基团的二价有机基团。