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公开(公告)号：EP4029873A1
公开(公告)日：2022-07-20
申请号：EP21197673.3
申请日：2015-09-17
申请人： Zymeworks Inc.
发明人： WINTERS, Geoffrey C. , RICH, James R. , GARNETT, Graham Albert Edwin , MANDEL, Alexander Laurence , HSIEH, Tom Han Hsiao , BOURQUE, Elyse Marie Josee , BARNSCHER, Stuart Daniel
IPC分类号： C07K7/02 , A61K38/05 , A61K47/50 , A61P35/00 , C07D207/08 , C07K5/027 , C07D207/448
摘要： Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
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2.发明公开COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND FIBROSIS-RELATED CONDITIONS 审中-公开用于治疗纤维化和纤维化相关病症的组合物
公开(公告)号：EP3271320A1
公开(公告)日：2018-01-24
申请号：EP16764055.6
申请日：2016-03-18
IPC分类号： C07C39/42 , C07C39/15 , C07C65/03 , C07C211/29 , C07C217/48 , C07C47/575 , C07D261/14 , C07D233/78 , C07D207/267 , C07D207/36 , C07D207/408 , C07D207/448 , C07D263/42 , C07D263/44 , C07D209/48 , A61K31/165 , A61K31/381
CPC分类号： C07D233/78 , C07C39/12 , C07C39/15 , C07C47/575 , C07C59/52 , C07C59/54 , C07C215/48 , C07C215/54 , C07C239/20 , C07D207/26 , C07D207/267 , C07D207/36 , C07D207/38 , C07D207/408 , C07D207/448 , C07D209/48 , C07D233/96 , C07D261/14 , C07D263/38 , C07D263/44
摘要： The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of fibrosis and fibrosis-related conditions.
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公开(公告)号：EP2379493A4
公开(公告)日：2012-07-25
申请号：EP09831324
申请日：2009-12-11
申请人： UNIV MELBOURNE
IPC分类号： C07C337/08 , A61K31/28 , A61K31/402 , A61K31/47 , A61K31/4706 , A61K38/08 , A61K51/04 , A61K51/06 , A61P35/00 , C07D207/448 , C07D295/135 , C07F1/08 , C07F3/06 , C07F5/02 , C07F9/40
CPC分类号： C07C335/40 , A61K38/08 , A61K51/0478 , A61K51/088 , C07C337/08 , C07D207/44 , C07D207/452 , C07D215/12 , C07D215/38 , C07D295/135 , C07F5/04 , C07F9/38 , C07F9/4021 , C07K7/06 , C07K7/086
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公开(公告)号：EP2234967A1
公开(公告)日：2010-10-06
申请号：EP08700739.9
申请日：2008-01-28
IPC分类号： C07D207/448 , C07D207/263 , C07D307/34 , C07C233/09 , A61K31/4015 , A61K31/34 , A61K31/16 , A61K31/216 , A61P31/20
CPC分类号： C07C235/34 , C07D207/444 , C07D207/46 , C07D207/50 , C07D307/60
摘要： The present invention relates to compounds from mycelium of Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) infection.
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5.发明公开
公开(公告)号：EP1506959A2
公开(公告)日：2005-02-16
申请号：EP04104605.3
申请日：2004-09-22
IPC分类号： C07D207/448 , C07D207/46 , C07D493/08 , C07C69/732 , C07C217/62 , C07F9/22 , C07C233/17 , C07F7/10 , C07D491/06 , C07C243/38 , C07C239/20 , C07D335/10 , C07D417/12 , C07D333/24 , C07H19/06
CPC分类号： C07D207/416 , C07B2200/11 , C07C43/23 , C07C69/712 , C07C69/734 , C07C217/62 , C07C217/80 , C07C233/18 , C07C235/20 , C07C243/38 , C07C281/02 , C07C2603/50 , C07D207/452 , C07D211/46 , C07D333/16 , C07D335/16 , C07D409/14 , C07D493/08 , C07F7/1844 , C07F9/65586 , C07H21/00
摘要： Compounds of formula (IIa):
are provided where:
X is a group capable of being cleaved from the α-carbon atom to form an ion of formula (I')
C is a carbon atom bearing a single positive charge or a single negative charge;
The invention further provides compounds of formula (IIb):
where:
X is a counter-ion to C .
The compounds of formula (IIa) and (IIb) may form ions of formula (I') by either cleaving the C-X bond between X and the α-carbon atoms in the case of the compounds of formula (IIa) or dissociating X in the case of compounds of formula (IIb).摘要翻译： 提供式（IIa）化合物：
其中：X是能够从α-碳原子裂解形成式（I'）的离子的基团。C是具有单个 正电荷或单负电荷; 本发明进一步提供式（IIb）化合物：其中：X为与C的反离子。 在式（IIa）和（IIb）化合物的情况下，式（IIa）和（IIb）的化合物可以通过在X和α-碳原子之间切割CX键而形成式（I'）的离子或 在式（IIb）化合物的情况下解离X。 -
公开(公告)号：EP1293500A3
公开(公告)日：2003-04-02
申请号：EP02079410.3
申请日：1996-08-29
IPC分类号： C07D207/448 , C07C255/08 , C07B63/04
CPC分类号： C07D207/448 , C07C253/32 , C07C255/08
摘要： A method for the preparation of an acrylonitrile solution manifesting transparency, precluding coloration and opacification during the course of handling, and excelling in stability, is provided. The acrylonitrile solution of maleimide is such that, when it is subjected to a forced coloration test, the differences Δ L, Δa, and Δb values (invariably as absolute values) each between L, a, and b values before and after the test are respectively not more than 5, not more than 5, and not more than 10. The acrylonitrile solution of maleimide is prepared by purifying a crude maleimide; applying a primary antioxidant and a secondary antioxidant to the purified maleimide in the molten state; solidifying the molten maleimide by cooling; and subsequently dissolving the solidified maleimide in acrylonitrile.
摘要翻译： 提供了一种制备丙烯腈溶液的方法，该方法表现出透明性，防止处理过程中的着色和不透明，并且稳定性优异。 马来酰亚胺的丙烯腈溶液在进行强制着色试验时，试验前后的L，a，b各值之差ΔL，Δa，Δb值（总是作为绝对值）为 分别不超过5，不超过5，不超过10.马来酰亚胺的丙烯腈溶液通过纯化粗制马来酰亚胺制备; 将主要抗氧化剂和次要抗氧化剂施加到熔融状态的纯化马来酰亚胺上; 通过冷却使熔化的马来酰亚胺固化; 随后将固化的马来酰亚胺溶解在丙烯腈中。
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公开(公告)号：EP0334497B1
公开(公告)日：2002-05-15
申请号：EP89301970.3
申请日：1989-02-28
发明人： Kita, Yuichi , Nakagawa, Masakazu , Kanei, Hitoshi , Fukui, Akio
IPC分类号： C07D207/448 , C07D207/452 , C07D401/04
CPC分类号： C07D207/448 , C07D401/04
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公开(公告)号：EP0437342B1
公开(公告)日：1997-03-26
申请号：EP91300133.5
申请日：1991-01-09
发明人： Kita, Yuichi , Kishino, Kazuo , Tsurume, Hiroko
IPC分类号： C07D207/448 , C07B63/04
CPC分类号： C07D207/448 , C07D207/452
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公开(公告)号：EP0403240B1
公开(公告)日：1994-08-24
申请号：EP90306417.8
申请日：1990-06-13
IPC分类号： C07D207/444 , C07D207/448 , C07D207/452
CPC分类号： C07D207/448
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公开(公告)号：EP0213933B1
公开(公告)日：1994-08-03
申请号：EP86306648.6
申请日：1986-08-28
IPC分类号： C07D207/448
CPC分类号： C07D207/448 , Y02P20/584
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