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公开(公告)号：EP3866773B1
公开(公告)日：2024-08-28
申请号：EP19872797.6
申请日：2019-10-16
IPC分类号： A61K31/122 , A61P9/02 , C07B37/12 , C07D213/74 , C07D231/18 , C07D239/60 , C07D285/04 , C07D291/06 , C07D319/06
CPC分类号： A61P9/02 , C07C69/06 , C07C2601/1020170501 , C07C69/36 , C07C49/417 , C07C59/80 , C07C59/205 , C07C59/21 , C07C69/63 , C07C49/16 , C07C69/716 , C07C311/51 , C07D285/04 , C07D291/06 , C07D213/74 , C07D231/18 , C07D239/60 , C07D319/06
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公开(公告)号：EP4051663B1
公开(公告)日：2024-02-21
申请号：EP20800097.6
申请日：2020-10-29
发明人： TAN, Hongyu , HAN, Licheng
IPC分类号： C07D213/74
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3.发明公开
公开(公告)号：EP4313938A1
公开(公告)日：2024-02-07
申请号：EP22716644.4
申请日：2022-03-23
申请人： Modernatx, Inc.
发明人： BENENATO, Kerry E. , CORNEBISE, Mark , HENNESSY, Edward , SEEPERSAUD, Mohindra , DANNEMAN, Michael W.
IPC分类号： C07C233/36 , C07C233/38 , C07C233/40 , C07C233/58 , C07C233/78 , C07C235/10 , C07C235/40 , C07C237/22 , C07C311/05 , C07C311/24 , C07D205/04 , C07D213/74 , C07D261/08 , C07D271/04 , C07D285/10 , C07D307/24 , C07D309/08 , A61K9/00
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4.发明授权
公开(公告)号：EP3902796B1
公开(公告)日：2024-02-07
申请号：EP19839715.0
申请日：2019-12-17
发明人： WU, Tom Yao-hsiang , JIN, Qihui
IPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D213/74 , A61K31/444 , A61K31/4439 , A61K31/4155 , A61K31/41 , A61P35/00
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公开(公告)号：EP3495349B1
公开(公告)日：2023-06-28
申请号：EP18214953.4
申请日：2012-10-22
发明人： ORTEGA MUÑOZ, Alberto , FYFE, Matthew Colin Thor , MARTINELL PEDEMONTE, Marc , ESTIARTE MARTÍNEZ, María de los Ángeles , VALLS VIDAL, Nuria , KURZ, Guido , CASTRO PALOMINO LARIA, Julio Cesar
IPC分类号： C07D213/74 , C07C211/35 , A61K31/135 , A61P35/00 , A61P31/12 , A61P25/00
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公开(公告)号：EP4134364A3
公开(公告)日：2023-06-14
申请号：EP22197951.1
申请日：2014-10-17
发明人： BENNETT, Michael, John , BETANCORT, Juan, Manuel , BOLOOR, Amogh , KALDOR, Stephen, W. , STAFFORD, Jeffrey, Alan , VEAL, James Marvin
IPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/73 , C07D213/74 , C07D217/24 , C07D237/14 , C07D239/54 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/06 , C07D409/04 , C07D413/06 , C07D417/04 , C07D471/04 , C07D495/04 , A61P35/00
摘要： The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.
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公开(公告)号：EP4146627A1
公开(公告)日：2023-03-15
申请号：EP21795351.2
申请日：2021-04-29
申请人： United States Government as represented by the Department of Veterans Affairs , The Research Foundation for The State University of New York , Icahn School of Medicine at Mount Sinai
发明人： MALLIPATTU, Sandeep , DAS, Bhaskar
IPC分类号： C07D213/74 , A61K31/44 , A61K31/167 , A61K31/573 , A61K31/69 , A61P13/12 , A61P25/28 , C07D471/04 , C07F5/02
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公开(公告)号：EP2440547B1
公开(公告)日：2022-11-30
申请号：EP10757474.1
申请日：2010-06-14
发明人： TAZI, Jamal , MAHUTEAU, Florence , NAJMAN, Romain , SCHERRER, Didier , CAMPOS, Noëlie , GARCEL, Aude
IPC分类号： C07D213/74 , C07D215/38 , C07D241/44 , C07D403/12 , A61K31/4709 , A61K31/4985 , A61P3/10 , A61P17/00 , A61P19/10 , A61P21/00 , A61P25/28 , A61P27/12 , A61P31/12 , C07D215/46 , C07D215/42 , C07D401/12 , A61P9/10
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公开(公告)号：EP4074695A1
公开(公告)日：2022-10-19
申请号：EP22155976.8
申请日：2012-10-22
发明人： ORTEGA MUÑOZ, Alberto , FYFE, Matthew Colin Thor , MARTINELL PEDEMONTE, Marc , ESTIARTE MARTÍNEZ, María de los Ángeles , VALLS VIDAL, Nuria
IPC分类号： C07D213/74 , C07C211/35 , A61K31/135 , A61P35/00 , A61P31/12 , A61P25/00
摘要： The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
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公开(公告)号：EP4003957A1
公开(公告)日：2022-06-01
申请号：EP20746194.8
申请日：2020-07-24
申请人： Medichem, S.A.
IPC分类号： C07D213/74
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