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公开(公告)号：EP4188937A1
公开(公告)日：2023-06-07
申请号：EP21849222.1
申请日：2021-07-30
申请人： Ascribe Bioscience
发明人： EAGAN, James
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公开(公告)号：EP4182326A1
公开(公告)日：2023-05-24
申请号：EP21745806.6
申请日：2021-07-16
申请人： Université de Bretagne Occidentale , Université de Tours , Centre National de la Recherche Scientifique , Institut National de la Santé et de la Recherche Médicale
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公开(公告)号：EP3740212A2
公开(公告)日：2020-11-25
申请号：EP18890684.6
申请日：2018-12-13
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公开(公告)号：EP0852500A4
公开(公告)日：2007-11-14
申请号：EP96933175
申请日：1996-09-27
申请人： ZENEUS PHARMA LTD , UNIV CITY
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7028 , A61P29/00 , A61P31/00 , A61P35/00 , C07H15/04 , C07H15/10 , C07H15/14 , A61K31/35 , C07D309/08 , C07D309/10 , C07D309/12 , C07D309/14 , C07H15/02 , C07H15/08
CPC分类号： C07H15/04
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公开(公告)号：EP0794788A4
公开(公告)日：2000-05-24
申请号：EP95943691
申请日：1995-12-06
申请人： NEORX CORP
发明人： THEODORE LOUIS J , AXWORTHY DONALD B , RENO JOHN M
IPC分类号： A61K31/7028 , A61K47/48 , A61K51/08 , A61P1/16 , C07H15/04 , C07H15/14 , C07H15/26 , A61K31/73 , A61K38/14 , A61K51/06 , C07H15/02 , C07K9/00
CPC分类号： B82Y5/00 , A61K47/6893 , A61K51/0465 , A61K2121/00 , C07H15/04 , C07H15/14
摘要： Hepatic-directed compounds, reagents useful in making such compounds and methods and compositions are discussed. The hepatic-directed compounds are comprised of at least three hexose residues, preferably galactose residues, and of a functional moiety capable of reacting with a binding moiety, a targeting moiety, or an active agent. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from metabolic mechanisms encountered by compounds which are not so directed. The hepatic-directed compounds are used to deliver moieties and agents to the liver and to improve targeting ratio.
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公开(公告)号：EP1465582B1
公开(公告)日：2010-10-13
申请号：EP03704358.5
申请日：2003-01-07
发明人： BEHLER, Ansgar , CLASEN, Frank
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7.发明公开DERIVATIVES OF PENTOSE MONOSACCHARIDES AS ANTI-INFLAMMATORY COMPOUNDS 审中-公开PENTOSEMONOSACCHARIDEN作为抗炎化合物衍生物
公开(公告)号：EP1902063A2
公开(公告)日：2008-03-26
申请号：EP05850707.0
申请日：2005-12-22
发明人： SATTIGERI, Jitendra, Viswajanani , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , NAGARAJAN, Muthukaman , SHIRUMALLA, Raj Kumar , AULAKH, Gurpreet Kaur , RAY, Abhijit
IPC分类号： C07H15/02
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders.
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8.发明公开
公开(公告)号：EP1680133A2
公开(公告)日：2006-07-19
申请号：EP04791421.3
申请日：2004-10-20
申请人： Glykos Finland Oy
发明人： ANGSTRÖM, Jonas , MILLER-PODRAZA, Halina , PANTZAR, Martina , KARLSSON, Karl-Anders , BLOMQVIST, Maria , HEISKANEN, Annamari , NIEMELÄ, Ritva , HELIN, Jari , NATUNEN, Jari
IPC分类号： A61K31/7028 , A61K31/7012 , A61P31/12 , C07H15/02
CPC分类号： A61K31/7028
摘要： The present invention relates to long branched poly-N-acetyllactosamines and analogous spacer modified divalent sialosides binding to the large binding site of influenza hemagglutinin. The invention further relates to the method for evaluating the potential of a chemical entity to bind to a molecule or molecular complex comprising a large binding site of influenza hemagglutinin. The invention also provides ligands to influenza hemagglutinin for use in the prevention and/or treatment of influenza.
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公开(公告)号：EP1219659A4
公开(公告)日：2004-03-17
申请号：EP00954985
申请日：2000-08-24
发明人： TSUCHIDA EISHUN , TAKEOKA SHINJI , SOU KEITARO , OHKAWA HARUKI
IPC分类号： C07H15/02 , C07C229/26 , C07C233/47 , C07C237/22 , C07C271/22 , C07K5/02 , C07K7/02 , C07K14/00 , C08B37/00 , C08G65/333 , C08G69/10 , C07K5/06 , C07K5/08 , C07K5/10
CPC分类号： C07C237/22 , C07C229/26 , C07C233/47 , C07C271/22 , C07K5/02 , C07K5/0215 , C07K7/02 , C07K14/001
摘要： An amphipathic compound having a dendritic structure represented by structural formula (I). In the formula (I), R0 is a hydrophilic group; R1's and R2's each independently is a hydrophobic group; and n is an integer of 1 to 4. This amphipathic compound can take advantage of the intermolecular interaction to stably fix a water-soluble polymer on the surface and can hold the same while retaining its intact function.
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公开(公告)号：EP0794788B1
公开(公告)日：2003-05-14
申请号：EP95943691.6
申请日：1995-12-06
申请人： NEORX CORPORATION
IPC分类号： A61K31/715 , A61K38/14 , A61K51/06 , C07H15/02 , C07K9/00
CPC分类号： B82Y5/00 , A61K47/6893 , A61K51/0465 , A61K2121/00 , C07H15/04 , C07H15/14
摘要： Hepatic-directed compounds, reagents useful in making such compounds and methods and compositions are discussed. The hepatic-directed compounds are comprised of at least three hexose residues, preferably galactose residues, and of a functional moiety capable of reacting with a binding moiety, a targeting moiety, or an active agent. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from metabolic mechanisms encountered by compounds which are not so directed. The hepatic-directed compounds are used to deliver moieties and agents to the liver and to improve targeting ratio.
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