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公开(公告)号：EP3740212A2
公开(公告)日：2020-11-25
申请号：EP18890684.6
申请日：2018-12-13
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公开(公告)号：EP3052134A2
公开(公告)日：2016-08-10
申请号：EP14789446.3
申请日：2014-10-02
发明人： LIN, Songnian , YAN, Lin , KEKEC, Ahmet , ZHU, Yuping , HUNTER, David N. , HUO, Pei , FENG, Danqing , NARGUND, Ravi P. , MOYES, Christopher R. , ZHAO, Zhiqiang , PIPIK, Brenda , PISSARNITSKI, Dmitri , DUFFY, Joseph L. , GUIDRY, Erin N.
CPC分类号： A61K47/61 , A61K38/28 , A61K47/549 , A61K47/64 , C07K14/62
摘要： Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
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公开(公告)号：EP3096754B1
公开(公告)日：2018-08-29
申请号：EP15740828.7
申请日：2015-01-16
发明人： MANDAL, Mihir , TANG, Haifeng , XIAO, Li , SU, Jing , LI, Guoqing , YANG, Shu-Wei , PAN, Weidong , TANG, Haiqun , DEJESUS, Reynalda , HICKS, Jacqueline , LOMBARDO, Matthew , CHU, Hong , HAGMANN, William , PASTERNAK, Alex , GU, Xin , JIANG, Jinlong , DONG, Shuzhi , DING, Fa-Xiang , LONDON, Clare , BISWAS, Dipshikha , YOUNG, Katherine , HUNTER, David N. , ZHAO, Zhiqiang , YANG, Dexi
IPC分类号： C07D257/04 , A61P31/04 , A61K31/41 , A61K31/4184 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/12
CPC分类号： C07D491/048 , A61K31/197 , A61K31/407 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D257/04 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , Y02A50/473 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
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公开(公告)号：EP3096754A1
公开(公告)日：2016-11-30
申请号：EP15740828.7
申请日：2015-01-16
发明人： MANDAL, Mihir , TANG, Haifeng , XIAO, Li , SU, Jing , LI, Guoqing , YANG, Shu-Wei , PAN, Weidong , TANG, Haiqun , DEJESUS, Reynalda , HICKS, Jacqueline , LOMBARDO, Matthew , CHU, Hong , HAGMANN, William , PASTERNAK, Alex , GU, Xin , JIANG, Jinlong , DONG, Shuzhi , DING, Fa-Xiang , LONDON, Clare , BISWAS, Dipshikha , YOUNG, Katherine , HUNTER, David N. , ZHAO, Zhiqiang , YANG, Dexi
IPC分类号： A61K31/41 , A61K31/4184 , C07D257/04
CPC分类号： C07D491/048 , A61K31/197 , A61K31/407 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D257/04 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , Y02A50/473 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
摘要翻译： 本发明涉及金属-β-内酰胺酶抑制剂的式（I）化合物，这种化合物的合成，以及这些化合物与β-内酰胺抗生素一起用于克服抗性的用途。
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