公开(公告)号：EP4337672A1

公开(公告)日：2024-03-20

申请号：EP22727095.6

申请日：2022-05-03

申请人： DSM IP Assets B.V.

发明人： HEIDL, Marc ,  SCHAERER, Thomas ,  SCHLIFKE-POSCHALKO, Alexander

IPC分类号： C07K1/30 ,  C07K5/083

公开(公告)号：EP4326739A1

公开(公告)日：2024-02-28

申请号：EP22722205.6

申请日：2022-04-11

申请人： Cytiva BioProcess R&D AB

发明人： RODRIGO, Gustav

IPC分类号： C07K1/30 ,  C07K1/32

公开(公告)号：EP3040453B1

公开(公告)日：2024-01-03

申请号：EP14839877.9

申请日：2014-08-27

发明人： YAMANISHI, Yoko ,  ARAI, Fumihito ,  KURIKI, Hiroki

IPC分类号： C30B29/58 ,  C07K1/30 ,  C07K14/80 ,  C12N9/00 ,  C12N9/24 ,  C30B7/12 ,  C30B30/02 ,  C12N9/36 ,  C12N9/06 ,  B25J7/00

公开(公告)号：EP2803349B1

公开(公告)日：2023-09-27

申请号：EP14176511.5

申请日：2010-05-27

发明人： Bruckschwaiger, Leopold ,  Svatos, Sonja ,  Nürnberger, Julia ,  Teschner, Wolfgang ,  Butterweck, Harald Arno ,  Schwarz, Hans-Peter ,  Gundinger, Thomas ,  Koelbl, Bernhard ,  Grausenburger, Reinhard ,  Pljevljakovic, Azra

IPC分类号： A61K9/00 ,  C07K1/30 ,  C07K1/36 ,  A61K35/16 ,  A61K38/17 ,  A61P13/12 ,  A61P7/00 ,  A61P27/02 ,  A61P31/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  A61K9/08 ,  A61K47/18 ,  C07K16/06

公开(公告)号：EP4178978A1

公开(公告)日：2023-05-17

申请号：EP21748524.2

申请日：2021-07-08

申请人： Grifols Worldwide Operations Limited

发明人： LINDSAY, Myles ,  ZIMMERMAN, Thomas P. ,  WOZNICHAK, Michelle ,  SINGH, Deepa ,  ROMES, Erin ,  ORLOVA, Natalia ,  SILVERSTEIN, Rebecca

IPC分类号： C07K16/06 ,  C07K1/16 ,  C07K1/30 ,  C07K1/34 ,  C07K1/36 ,  A61K39/395

公开(公告)号：EP4119574A1

公开(公告)日：2023-01-18

申请号：EP22191464.1

申请日：2013-02-25

申请人： Takeda Pharmaceutical Company Limited

发明人： BRUCKSCHWAIGER, Leopold ,  GUNDINGER, Thomas ,  NUERNBERGER, Julia ,  TESCHNER, Wolfgang ,  SCHWARZ, Hans-Peter

IPC分类号： C07K16/06 ,  A61K39/395 ,  A61K35/16 ,  C07K1/30

摘要： Among other aspects, the present invention provides methods for the manufacture of blood protein compositions from pooled plasma. In one embodiment, the invention provides an alcohol fractionation scheme that allows for significant increases in the yield of blood proteins purified from the starting plasma sample. In a specific embodiment, a method for fractionating pooled Q plasma is provided, the method comprising an initial low pH, high alcohol precipitation step. The present invention also provides pharmaceutical compositions of therapeutic blood proteins.

公开(公告)号：EP4073104A2

公开(公告)日：2022-10-19

申请号：EP20835694.9

申请日：2020-12-10

申请人： Takeda Pharmaceutical Company Limited

发明人： FLEISCHANDERL, Daniel ,  DATTENBOECK, Christoph ,  PETRUSHEVSKA-SEEBACH, Katerina ,  GATTERNIG, Thomas ,  PURTSCHER, Martin ,  JUNGBAUER, Alois ,  ENGELMAIER, Hannah ,  HAMMERSCHMIDT, Nikolaus

IPC分类号： C07K14/745 ,  C07K14/755 ,  C07K1/30

公开(公告)号：EP4061826A1

公开(公告)日：2022-09-28

申请号：EP20811986.7

申请日：2020-11-20

申请人： CSL Behring AG

发明人： EL MENYAWI, Ibrahim ,  VON NORDHEIM, Marcus

IPC分类号： C07K1/30 ,  C07K1/34

公开(公告)号：EP4050017A1

公开(公告)日：2022-08-31

申请号：EP21158984.1

申请日：2021-02-24

申请人： PreOmics GmbH

发明人： KULAK, Nils A. ,  JOHANSSON, Sebastian H. ,  HARTINGER, Katrin

IPC分类号： C07K1/30 ,  G01N33/68

摘要： The present invention relates to a method of processing or fractionating a sample comprising proteins, polypeptides and/or peptides, said method comprising (a) changing the physicochemical conditions of said sample; and (b) performing one or both of the following (i) and (ii): (i) adding solid particulate matter to said sample; and (ii) performing said method in a vessel with a rough surface; wherein steps (a) and (b) can be effected concomitantly or in any order; and wherein said processing or fractionating yields one or more first fractions of proteins, polypeptides and/or peptides as a precipitate on said particulate matter and/or said inhomogeneous surface, and a second fraction of proteins, polypeptides and/or peptides remaining in a supernatant.

公开(公告)号：EP4039249A1

公开(公告)日：2022-08-10

申请号：EP22164436.2

申请日：2011-05-26

申请人： Baxalta GmbH ,  Baxalta Incorporated

发明人： Teschner, Wolfgang ,  Schwarz, Hans-Peter ,  Madlener, Ruth ,  Svatos, Sonja ,  Pljevljakovic, Azra ,  Weber, Alfred

IPC分类号： A61K9/08 ,  A61K47/18 ,  A61K9/00 ,  A61K38/17 ,  C07K16/00 ,  A61K35/16 ,  A61P7/00 ,  A61P13/12 ,  A61P27/02 ,  A61P31/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  C07K1/30 ,  C07K1/36 ,  C07K16/06

摘要： The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and/or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.