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    USE OF AAV-EXPRESSED M013 PROTEIN AS AN ANTI-INFLAMMATORY THERAPEUTIC
    2.
    发明公开
    USE OF AAV-EXPRESSED M013 PROTEIN AS AN ANTI-INFLAMMATORY THERAPEUTIC 审中-公开
    VERWENDUNG VON AAV-EXPRIMIERTEM M013-PROTEIN ALSENTZÜNDUNGSHEMMENDESTHERAPEUTIKUM

    公开(公告)号：EP3116898A1

    公开(公告)日：2017-01-18

    申请号：EP15761543.6

    申请日：2015-03-11

    申请人： University of Florida Research Foundation, Inc.

    发明人： MCFADDEN, Douglas Grant ,  LEWIN, Alfred S. ,  LUCAS, Alexandra Rose ,  ILDEFONSO, Cristhian J. ,  RAHMAN, Mohammed Masmudur

    IPC分类号： C07K14/065

    CPC分类号： C07K14/005 ,  A61K9/0048 ,  A61K38/162 ,  A61K48/00 ,  A61K48/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/24022 ,  C12N2750/14143

    摘要： Disclosed are methods and compositions for preventing, treating, and/or ameliorating one or more symptoms of inflammation in a mammal. In particular, viral vectors and medicaments containing them are disclosed, which are useful in the prophylaxis, therapy, or amelioration of symptoms of one or more inflammatory-mediated mammalian diseases, such as age-related macular degeneration (AMD), arthritis, Bechet's disease, Best macular dystrophy, corneal inflammation, diabetic retinopathy, drusen formation, dry AMD, dry eye, geographic atrophy, glaucomaocular neovascularization, Lupus erythematosus, macular degeneration, Mallatia Leventinese and Doyne honeycomb retinal dystrophy, nephritis, ocular hypertension, ocular inflammation, recurrent uveitis, Sorsby fundus dystrophy, vasculitis, vitreoretinopathy, wet AMD, or related disorders. In exemplary methods, administration of a pharmaceutical composition comprising a recombinant viral vector that delivers a secretable and cell-penetrating M013 protein or peptide to a subject in need thereof facilitated treatment of particular human disorders such as AMD, ocular neovascularization, uveitis, and related inflammatory ocular disease.

    摘要翻译： 公开了用于预防，治疗和/或改善哺乳动物中一种或多种炎症症状的方法和组合物。 特别地，公开了含有它们的病毒载体和药物，其可用于预防，治疗或改善一种或多种炎症介导的哺乳动物疾病的症状，例如年龄相关性黄斑变性（AMD），关节炎，Bechet氏病 ，最佳黄斑营养不良症，角膜炎，糖尿病性视网膜病变，玻璃疣形成，干性AMD，干眼症，地域性萎缩，青光眼新生血管形成，红斑狼疮，黄斑变性，马拉维亚Leventinese和Doyne蜂窝状视网膜营养不良，肾炎，眼高压，眼部炎症，复发性葡萄膜炎 ，Sorsby眼底营养不良，血管炎，玻璃体视网膜病变，湿性AMD或相关疾病。 在示例性方法中，包含向有需要的受试者递送可分泌和细胞穿透的M013蛋白或肽的重组病毒载体的药物组合物的给药有助于治疗特定的人类疾病如AMD，眼新生血管形成，葡萄膜炎和相关炎症 眼病。

    METHOD OF PRODUCING ALPHA 2,3-SIALYLTRANSFERASE
    8.
    发明公开
    METHOD OF PRODUCING ALPHA 2,3-SIALYLTRANSFERASE 失效
    METHOD FOR ALPHA 2,3-唾液酸转移酶的制造

    公开(公告)号：EP0866855A4

    公开(公告)日：2000-02-02

    申请号：EP96937920

    申请日：1996-11-15

    申请人： COMMW SCIENT IND RES ORG

    发明人： JACKSON RON

    IPC分类号： C12N15/09 ,  C12N5/10 ,  C12N9/10 ,  C12N15/00 ,  C12N15/39 ,  C12R1/91 ,  C12R1/92 ,  C07K14/065

    CPC分类号： C12N9/1081

    摘要： A method of preparation of lysate having alpha 2,3-sialyltransferase activity is disclosed. A cell culture having essentially no endogenous expression of eukaryotic alpha 2,3-sialyltransferase is infected with myxoma virus. The harvested triton lysates include significant quantities of a protein having eukaryotic alpha 2,3-sialyltransferase activity. Compositions having in vitro alpha 2,3-sialyltransferase activity and comprising a protein extract of lysates of the aforementioned lysates are also provided for.